International team uses genomic tools to discover gene for childhood genetic disorder
...se the disease. These findings provided definitive proof that the LRPPRC gene is responsible for LSFC. "Ge... were really excited, but wanted more experimental proof that this was indeed the culprit," says Mootha, who was collaborating with MDS Proteomics in Denmark...Researchers develop guidelines to establish identity of genes responsible for complex diseases
...elines which scientists can use as a benchmark for proof of identification of the multiple genes responsibl...ficult task in deciding what represents definitive proof of a particular gene's action. As well as looking at human illness and disease, the authors of the r...Researchers reveal new secrets of the brain
... and his research team present the most convincing proof to date that the adult brain can rewire itself in response to outside world. While many neuroscientists had begun to speculate that adult brains might be more dynamic than once thought, neuroscience orthodoxy still held that adult brains are relative...European scholars support development of germ line modification
...ady work in a range of animal models. There is now proof of concept that somatic gene therapy can be used for clinical purposes in humans. Some of the technical problems affecting somatic gene modification do not affect IGM if this is performed on the fertilized egg or human stem cells. Techniques for modi...Gene responsible for rewinding body's 'clock' described by scientists at TSRI
...ed to be this photoreceptor, but scientists lacked proof of it until now. A Light Even the Blind Can See In mammals, melanopsin is expressed in approximately 1000 cells per retina. "Most of these cells project directly to the master circadian oscillator in the brain," says Satchidananda Panda, Ph.D., a g...UIC scientists provide first images of HIV in living cells
...zing glimpses of HIV in action, but provide visual proof that HIV enlists the assistance of its host to wreak havoc on the body's defenses. The virus can be seen traveling along a part of the host cell's own skeletal framework of microtubules as it makes its way from the outer membrane to the nucleus. The...Modified crop breeds toxic hybrid
... is likely to be seized on by environmentalists as proof that field trials of GM crops are unsafe. In lab experiments, Matthew Halfhill at the University of North Carolina in Greensboro and colleagues took oilseed rape (canola) that had been modified to contain the insect resistance gene Bt and crossed it ...New genetic option for thwarting cancer
...nt even when p53 or Ink4a/Arf was absent, yielding proof that Cdk4 is required for a cell to become cancerous. Importantly, the mice that lack the Cdk4 gene appeared healthy, although they were smaller than average and sometimes developed diabetes, Kiyokawa said. That is, even without the Cdk4 gene, they d...UCSD bioengineers develop first computer model that predicts disease variant based on genetic defect
...ch is significant in that we are demonstrating the proof of concept for the first time." UCSD has formed a spin-off company, called Genomatica, to bring Palsson's in silico modeling technologies into commercial use....Molecular machine could develop drugs for bioweapons victims
... tularemia, Q-Fever and typhus." This new model is proof that large protein ribonucleic acid (RNA) complexes can be predicted on a computer, which opens up the possibility for rapidly modeling ribosomes from a variety of organisms. "The developed technique is very useful in structural and functional genom...Interpreting a climate record from 10,000-year-old migrating waters
... to the super computer's simulations, now have the proof that these assumptions are valid. "We were also interested in how big an effect changes in surface temperature and amount of rainfall would have on the water chemistry," noted William Glassley, leader of the team. To their surprise, these climate cha...Scientists prove how geckos stick, unlock secrets to making artificial gecko glue
...l bumps. These preliminary physical models provide proof that humans can fabricate synthetic gecko adhesive," he says. "The artificial foot-hair tip model opens the door to manufacturing dry, self-cleaning adhesive that works under water and in a vacuum," according to Autumn, who foresees countless applica...Gene variant increases risk of cardiac arrhythmia for African-Americans
...is especially significant because it constitutes a proof of principle that points the way to identifying more of these variants in different population groups," said Keating. "This is among the first pieces of a big puzzle of genetic affects on arrhythmia," he said. "We need to have many more pieces before...Scientist says ostrich study confirms bird 'hands' unlike those of dinosaurs
...ages of development and found what they believe is proof that birds could not have descended from dinosaurs. They also discovered the first concrete evidence of a thumb in birds. "Whatever the ancestor of birds was, it must have had five fingers, not the three-fingered hand of theropod dinosaurs," Feducc...New approach to malaria vaccine effective in mice
...l models of malaria. "This paper represents only a proof of principle," Schofield said. "It does not represent an optimized regime on any level, either in terms of synthesis of the GPI molecule or in the carrier protein." Schofield emphasized that since GPI is an essential molecule in all malaria parasites...Stanford scientists flick genetic switch; may lead to new disease treatments
...w RNA. Kay said that this initial work is a proof of concept. "The ultimate goal is to use this to treat a disease," Kay said. "We can do this by placing these molecules into standard gene-therapy vectors." As examples, he said researchers could deactivate virus genes or genes involved in cancer. Ka...Embryonic mouse stem cells reduce symptoms in model for Parkinson's disease
...nn, M.D., Acting Director of NINDS. "They provide proof of principle that we can start with embryonic stem cells and end up with dopamine neurons that are useful in a model for Parkinson's disease." Previous studies have shown that neural precursor cells (which are more limited in their potential than ES ...Children's Hospital Boston researchers use therapeutic cloning to create functional tissue in cows
...s and caused no signs of rejection. "The study is proof of principle that therapeutic cloning can be used to create tissues without the threat of rejection," says Anthony Atala, M.D., director of Tissue Engineering at Children's Hospital Boston and the senior author on the paper. "While more work needs to...UF researchers discover blood stem cells
...m a single cell," Scott said. "That was our formal proof that it was indeed a blood stem cell that was making these blood vessels." Scott's UF collaborators included Dr. Maria Grant, Dr. W. Stratford May and Ammon Peck. The study was funded by the National Institutes of Health, the Juvenile Diabetes Resear......em diseases and disorders. "These experiments are proof of principle that it is possible to change one lineage of adult stem cells into another using fat," said Duke's Henry Rice, M.D., pediatric surgeon and senior author of the paper published today (May 31, 2002) in the journal Biochemical and Biophysic...