NIH awards $18.2m to The Burnham Institute to develop Center on Proteolytic Pathways
...ved by the FDA for treatment of obesity, inhibited prostate cancer. The Center on Proteolytic Pathways is the newest plank in the Burnham Institute's Drug Discovery Initiative, the Institute's commitment to building up the intellectual and instrumental infrastructure needed to close the gap between discovery ...Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
...that lycopene may be able to inhibit the growth of prostate tumours and that its effect may be enhanced if it ...other fruits is associated with a reduced risk of prostate cancer. But, these observational findings have now been underpinned by new research demonstrating a ...New molecular link key to cellular proteins involved in cancer progression, other diseases
...es including cancer. In certain cancers, including prostate cancer and lymphomas, members of the Polycomb group (PcG) of proteins appear to abnormally switch genes from on to off, or "silence" them. The latest work revealed that they do so by placing a small molecule called ubiquitin on a portion of the prote...Phase II trials of second-generation antisense cancer drug planned following successful early study
...mone therapy. Twenty-five patients with localised prostate cancer that was to be removed by surgery were give...rostate Cancer Research Program. Two conventional prostate cancer hormone therapies, buserelin and flutamide, were given alongside OGX-011. Post surgery analys...Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...ting the large number of tumors, including breast, prostate and melanoma, that overexpress the antigen EphA2. Both antigen targets have recently been featured in new research reports suggesting their significance as potential targets for cancer treatment. The listeria-based cancer vaccine work was sponsored ...16th EORTC NCI AACR Symposium 'Molecular Targets and Cancer Therapeutics'
...dy shows lycopene and vitamin E inhibits growth of prostate tumours in mice, underpinning epidemiological evidence. Phase II trial in patients now under way. * Dr. Olivier Feron: A revolutionary approach to angiogenesis - exploiting tumour blood vessels to boost chemotherapy and radiotherapy instead of (or be...Human chromosome 5 final sequence analysis released to public
...uding those implicated in forms of kidney disease, prostate and colorectal cancer, leukemia, hypertension, diabetes and atherosclerosis. The chromosome 19 sequence was published in the April 1, 2004, issue of Nature. "I am confident that the interesting features that we have identified from this sequence inf...Researchers identify distinctive signature for metastatic prostate cancer
...chinery that could help clinicians predict whether prostate cancers are likely to spread or remain relatively ...hich drives normal development and regeneration of prostate tissue, is greatly activated in prostate cancers. This elevated activity distinguishes dangerous met...Charting the future in prostate cancer care: A call to action
...r, an estimated 230,000 men will be diagnosed with prostate cancer in the United States, and 30,000 are expect...isease. Today, about two million men are battling prostate cancer, and over the next decade, about three million more will be compelled to join the war. The n...Hunting illusive signs of natural selection
... might be involved in susceptibility to aggressive prostate cancer and since there is a large difference in the prevalence of prostate cancer between the European- and African-American populations, TRPV6 may be the selected gene. TRPV...Adaptive changes in the genome may provide insight into the genetics of complex disease
... implicated in thedevelopment or aggressiveness of prostate cancer. It and another gene in theregion, TRPV5, are also involved in calcium absorption in the kidney,intestine and placenta. Scientists had previously found that geneticvariation in a gene promoting lactose-tolerance in milk drinking Europeanpopula...Final Alert: 16th EORTC NCI AACR Symposium
...TRAIL R2 protein Lypcopene and vitamin E inhibits prostate tumours new laboratory results underpin epidemiol...ypol abandoned as a contraceptive can sensitise prostate cancer to radiotherapy patient trials now planned Please note: information above on news briefing ...Study reveals first genetic step necessary for prostate cancer growth
...hat may be the earliest step in the development of prostate cancer. The finding could open the door to new tes...ondition analogous to the earliest stages of human prostate cancer. Importantly, in the absence of additional genetic defects, the mice do not develop full-blow...New imaging technology at Joslin shown to detect early signs of type 1 diabetes
...p in human clinical trials to detect the spread of prostate cancer to the lymph nodes. "Given the known safety of magnetic nanoparticles in humans, the technology might someday be used in individuals who are genetically at risk for diabetes to detect this autoimmune process in its earliest stages," Dr. Benoi...Synthesized molecules studied as weapon to stop cell division in cancer cells
...e particularly effective against breast cancer and prostate cancer. It seems to relate to secondary sexual characteristics." However, a lot of work remains to be done to develop a drug, she cautions. "For instance, the inhibitor does not cross cell membranes. We can overcome that in the laboratory in order to...New compound could give some types of cancer the one-two punch
...mpound called OSU 111 has shown promise in killing prostate cancer cells. "It had a direct toxic effect on can...OSU 111 in laboratory experiments, the majority of prostate cancer tissue cells died within three days, Li said. "This compound stopped cell division in its tra...Study narrows search for genes placing men at increased risk for prostate cancer
...findings from the largest study of the genetics of prostate cancer undertaken to date. Results have zeroed in ...dentify specifically which genes lead to increased prostate cancer susceptibility. "This study will help us predict better who is at the highest risk for this...Other highlights in the August 18 JNCI
...five chromosomal regions that are likely to harbor prostate cancer susceptibility genes. Prostate cancer is th... factors for the disease, but no genes that confer prostate cancer susceptibility have been found to date. In an analysis of 426 families with histories of pros...JCI table of contents, 16 August, 2004
... the University of Washington, now investigate how prostate cancers evade this anti-tumor defense strategy. The researchers found that MIC-expressing prostate cancer cell lines were able to activate natural killer cells, thus, initially, this defense mechanis...... the University of Washington, now investigate how prostate cancers evade this anti-tumor defense strategy. The researchers found that MIC-expressing prostate cancer cell lines were able to activate natural killer cells, thus, initially, this defense mechanis...