Tag: "prostate" at biology news

Study evaluates biology of prostate cancer progression in African-American men

...ORONTO - Despite the fact that the death rate from prostate cancer is much higher in African-American men than in Caucasian men, little is known if prostate cancer biology could be different among the two racial groups. Researchers at The University of Texa...

Brain gliomas progress as function of crucial gene is lost

... active, and have described its role in breast and prostate cancer as well. The AP-2( transcription factor controls the expression of many genes, including c-Kit, which regulates cellular proliferation and differentiation, MUC18, an adhesion molecule involved in angiogenesis, and MMP2, which is involved in i...

Chemical in soy alters reproductive organs in male rats

...rs found the males had smaller testes and a larger prostate gland compared to unexposed rats. Although their sperm counts were normal, exposed adult males had lower testosterone levels and were also less likely to ejaculate when presented with the opportunity to mate with a female. "The effects of genistein ...

Pennsylvania chemist wins national award for drug research

... growth of solid tumors such as those of breast or prostate cancer. "We've learned a lot about how to operate on this playing field and have managed to bring some novel compounds into human clinical trials," he said. Maryanoff received his undergraduate and Ph.D. degrees from Drexel University in 1969 and 197...

Alliance for Cancer Gene Therapy announces $1.5 million in national grants to young investigators

...erapy research projects relating to neuroblastoma, prostate and ovarian cancers. The recipients are Dr.... TRAIL for future clinical trials in patients with prostate cancer; and Dr. Jeffrey Bartlett, at Children's Research Institute in Columbus, Ohio, for tumor targ...

Researcher explores tumors' survival strategy

...cancers; expression is increased in breast cancer, prostate cancer and melanoma and decreased in ovarian cancer. "The bottom line is that the environment that supports the growth of cancer cells and their development into tumors is regulated by a multitude of factors. One of these factors is SPARC or a class ...

Treatment of lupus in mice may point the way to human treatment

...tudies indicating that it suppresses the growth of prostate cancer; THA has potent antitumor activity in breast cancer. "Investigation of the potential role of these agents in autoimmune diseases are just beginning," said Mishra. He said that Christopher M. Reilly of the Medical University of South C...

UT Southwestern researchers developing new procedures to make bone-marrow transplants safer

... different areas, such as the treatment of breast, prostate and other cancers. "I'd like to see this apply to all transplants and become standard-operating procedure," she said. "This could establish a new paradigm." The research was partially supported by a grant from the Leukemia Association of North Centra...

ORNL, Georgia's Isotron develop promising new cancer treatment

... brain tumors, melanoma, sarcoma, certain types of prostate cancer, locally advanced breast cancer, cervical c...reating many of the some 257,000 combined cases of prostate cancer, cervical cancer, brain tumors and melanomas that claimed 64,700 lives in 1998. Theyre especi...

New center will probe links between diet, genes and disease

...e a 60 percent higher risk of being diagnosed with prostate cancer than Caucasian men do. Half of all adult Pima Indians in the United States have type 2 diabetes, compared to 6.5 percent of adult Americans of Caucasian descent. Genetics, diet, economic and social conditions, culture and behavior may all cont...

UNC studies target molecular defects implicated in cancer, genetic diseases

...bcl-xL have been found in malignant cancers of the prostate and have been correlated with increased resistance...orm in cancer cell lines, including cancers of the prostate and breast. In doing so, the UNC researchers were able to sensitize these cell lines to various chem...

Scientists discover gene 'signature' for tumor's tendency to spread

...distinction, and they tested it in breast cancers, prostate cancers and even in brain tumors called medulloblastomas. The researchers were surprised to find the same genetic signature associated with metastasis in several different tumor types. "We had no reason to believe it was this broadly applicable,'' R...

Versatile immunosuppressant drug may have new role in radiotherapy for cancer

... in other types of cancers, in particular lung and prostate cancer." The research team is now planning clinical trials looking at the combination of radiation and a rapamycin analogue in GBM and in lung cancer, and other researchers at the Mayo Clinic are evaluating rapamycin in phase I and II trials ...

Influences of sex on gene expression discussed at annual conference

... play a role in the development and progression of prostate and breast cancers. Despite diverse genetic and environmental factors contributing to prostrate and breast cancer, Diane Robins, PhD, University of Michigan Medical School, explained that both tumors initially are steroid hormone dependent. Hormonal ...

High selenium consumption may protect ex-smokers from bladder cancer

...ences of cancer, particularly lung, colorectal and prostate cancers. The most important dietary sources of selenium are meats, fish, cereal, dairy products and eggs. Some nuts, particularly Brazil nuts, contain high quantities of this element. This latest study, supported by the Dutch Cancer Society, represe...

Study provides direct evidence of the role of telomeres in prostate cancer development

... been proposed as an early and prevalent marker of prostate cancer process, according to a study presented tod...study provide the first direct evidence that human prostate cancer may progress, in the earliest phase, via chromosomal instability generated by short telomeres...

Leading cancer research organization urges FDA to speed approval of drugs for precancers

... large and composed of more abnormal tissue. With prostate cancer, studies have shown that 40 percent of all patients with high-grade prostatic intraepithelial neoplasia (HGPIN) and no detectable cancer develop cancer three years later, with cancer incidence growing to 80 percent in 10 years. "We need to ...

A red flag for lethal prostate cancer

... called EZH2 could be a warning sign of metastatic prostate cancer, according to scientists at the University ... of 55 genes found to be more active in metastatic prostate cancer than in localized prostate cancer. This is the first study linking EZH2 to solid tumors, acco...

New study expands look at high-dose vitamin D with docetaxel for advanced prostate cancer patients

...t docetaxel (Taxotere), for patients with advanced prostate cancer. The ASCENT (AIPC Study of Calcitriol Enhan...taxel alone for patients with androgen-independent prostate cancer (AIPC), an advanced form of prostate cancer. "Late-stage prostate cancer patients have few tr...

Heart disease gene linked to prostate cancer

... mutations in a "heart disease gene" in hereditary prostate cancer. The findings, which offer new evidence that at least some cases of prostate cancer may begin with an infection and inflammatory response, will be published online September 16,...

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