Phase II trials of second-generation antisense cancer drug planned following successful early study
...ibited the production of clusterin, a protein that protects cell survival and is widely distributed in body tissue. Clusterin is implicated in a range of activities, including apoptosis (programmed cell death). When it is over-produced, as it is many major cancers, clusterin can stop cancer cells from dying a...Study explores gene transfer to modify underlying course of Alzheimer's disease
...F) gene encased in a harmless viral coating, which protects the gene and facilitates its delivery to brain cells. The active part of the drug is the NGF gene, the human DNA strand that codes for the NGF protein, a natural substance that exerts positive effects on brain cells. A key objective of the study is t...Green, leafy spinach may soon power cellphones and laptops
... semiconductor that prevents electrical shorts and protects the protein complexes from the layer of metal that completes the sandwich. The researchers shone laser light on the device to create optical excitation, then measured the resulting current. "An important caveat is that we got very little current ou...JCI table of contents September 15, 2004
...markers of dis-ease. These data indicate that PGI2 protects against and TXA2 promotes atherosclerosis development. The use of TP antagonists and molecules with PG-like activity may therefore aid in atherosclerosis prevention. Furthermore these data fit well with previous work that indicated that low doses of...Picking prostanoids to provide protection
...markers of dis-ease. These data indicate that PGI2 protects against and TXA2 promotes atherosclerosis development. The use of TP antagonists and molecules with PG-like activity may therefore aid in atherosclerosis prevention. Furthermore these data fit well with previous work that indicated that low doses of...Purdue study finds antioxidant protects metal-eating plants
...t if there's something in the cell's interior that protects it from oxidative damage as the metal crosses the cell." In this study, Salt and his colleagues sampled a number of closely related plants that grow on soils naturally enriched in nickel. These plants ranged from those that didn't accumulate any nick...Green tea research leads to gum and other products
...cer cells for destruction. This change of behavior protects the healthy cells. Dr. Hsu discovered that the pol...elderly, Dr. Hsu noted. The green tea gum not only protects the tissue but stimulates the salivary glands to produce more moisture. Healthy people can chew the ...Other highlights in the September 1 JNCI
...cular pathway--the unfolded protein response--that protects cells from the harmful effects of unfolded proteins. Researchers have hypothesized that glucose-deprived tumor cells could be killed by disrupting this pathway. Kazuo Shin-ya, Ph.D., of the University of Tokyo, and colleagues investigated the effect ...APS awards more than $140,000 to minority students of physiology
... by better understanding the mechanisms of how EGF protects the intestine, this research may provide the basis for future therapeutic strategies for the treatment of human NEC. Alfredo Garcia III Wright State University Through the use of an in vitro experimental model, Mr. Garcia is studying the effects o...OHSU-VAMC study sheds light on estrogen's benefit for MS
...study showing treatment with low doses of estrogen protects mice from developing EAE, but the mechanism of the effect hadn't been fully characterized. And earlier this year, researchers in the United Kingdom found that human pregnancy elevated levels of the disease-fighting CD4+CD25+ T cells. However, "They d...Images reveal how rotavirus - leading cause of diarrhea - enters cells
...ne system recognizes when it attacks the virus and protects against infection. "The work is a clear example of the way in which structural studies can contribute to new good ideas about strategies for vaccines," says Senior Investigator Stephen Harrison, Ph.D., a Howard Hughes Medical Institute investigator ...Asian elephant sex pheromone transporter revealed
...ected and multifaceted role as a shuttle that both protects and transports the pheromone. The authors reveal that elephant serum albumin (ESA) transports the pheromone from serum to urine and it extends the period of time that the pheromone remains available for detection in the environment, without actually ...Body's own defense against H. pylori, cause of stomach ulcers and stomach cancer
...iversity has discovered the defense mechanism that protects the stomach against H. pylori infection. H. pylori is found in mostly in the stomach, where it thrives in the superficial mucin layer lining the stomach. The bacterium is rarely found in the deeper portion of the mucin layer, where the mucous cel...The telomere crisis: A crucial stage in breast cancer
...This process, known as "telomere crisis," normally protects against inappropriate long-term cell growths like cancer. Gray and his colleagues believe that "very rarely, the chromosome instability activates a specialized DNA-replication complex, telomerase, which can restore telomeres. Cells in which telomera...JCI table of contents, 2 August, 2004
...immunity specific for epitopes of oxidized LDL and protects from atherosclerosis AUTHOR CONTACTS: Christoph J. Binder or Joseph L. Witztum University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA Phone: 858-534-4402; Fax: 858-534-2005; E-mail: cbinder@ucsd.edu (C.J.B.), jwitztum@ucsd.......ty to insulin. Thus, Jip1 inactivation effectively protects against obesity and the development of insulin resistance. This finding posits Jip1 as a novel target for the rational design of drugs to combat obesity and Type 2 diabetes. Dr. Davis emphasizes that "Our study demonstrates that JIP1 plays a critical...Lake research offers clues to managing crayfish invasions
... more offspring and destroying the plant life that protects fish. "That these alternate states exist gives us some hope that we might be able to take lakes infested by rusty crayfish and force the system from one state to another," says Roth. To test this theory, he and other researchers are conducting an ex...Drug prevents chemotherapy-induced hearing loss, study finds
...hways, and it may actually increase the way a cell protects itself," said Leslie Muldoon, Ph.D., assistant professor of neurology, and cell and developmental biology, OHSU School of Medicine. But because NAC can turn off cisplatin's active element, platinum, the timing of its use is everything. The study fou...Unique partnership between UH, FDA opens path for scientific exchange
...rug approval pipeline firsthand, learn how the FDA protects the public health, have an opportunity to provide public service and gain insight into the decision-making process behind drug and device approvals for commercial marketing. "This partnership is incredibly important by means of educating our studen...Tips from the Journals of the American Society for Microbiology
.... Oral vaccination with Brucella melitensis WR201 protects mice against intranasal challenge with virulent Brucella melitensis 16M. Infection and Immunity, 72. 7: 4031-4039.) New Patch May Enhance Effects of Flu Virus Vaccine in Aging Population Researchers from Maryland have developed a patch d...