Tag: "protein" at biology news
Student science contest participation influences study, career choices, alumni say
...elp obese people by increasing the production of a protein
in human cells that would increase the amount of fat burned. This fundamental research could eventually lead to a drug that would induce weight loss in obese people, Desbiens said. Learning both the lab skills from professionals and how t...
International study findings link acne-like rash to effectiveness of new targeted cancer treatment
...onal antibody designed to home in selectively on a protein
called the epidermal growth factor (EGFR). EGFR is found on the surface of some cells and plays a role in regulating cell growth. Cetuximab interferes with the growth of cancer cells by binding to EGFR. It is approved by the Food and Drug Administrat...
Researchers find color sensitive atomic switch in bacteria
...rnia, Irvine, describe the versatile light-sensing protein
at levels of resolution smaller than a nanometer--...llography revealed the light-absorbing part of the protein
was present in two alternative positions, suggesting to us that light of different colors drives thi...
New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
...o correct the gene responsible for making a flawed protein
(the PMLRAR fusion protein) that causes APL. The research team used RT-PCR2 techniques to confirm the diagnosis of APL by identifying the rogue gene in their study patients. This further enabled them to establish a new classification for acute myelo...
New molecular link key to cellular proteins involved in cancer progression, other diseases
...mall molecule called ubiquitin on a portion of the protein
histone H2A, which is tightly associated with DNA....biquitinated, or modified by the attachment of the protein
ubiquitin, but neither the consequence of H2A ubiquitination nor the molecules responsible were know...
Phase II trials of second-generation antisense cancer drug planned following successful early study
...OGX-011* inhibited the production of clusterin, a protein
that protects cell survival and is widely distribu...sense drugs work by inhibiting the production of a protein
from a specifically targeted gene. As a second-generation antisense drug, OGX-011 is an advance on e...
Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
... discovered that the tail is produced when ActA, a protein
on the surface of the bacteria, interacts with a c.... The result is rapid polymerization of a skeletal protein
called actin that piles up and physically propels the newly formed bacteria around the cell. Portno...
Genetic differences might help distinguish thyroid cancers
...0 (CLDN10), and insulin-like growth factor binding protein
6 (IGFBP6). It also showed no change in two genes, caveolin-1 (CAV-1) or caveolin-2 (CAV-2). FTC cells, on the other hand, showed no expression by CLDN10 and low activity by IGFBP6 and/or by CAV1 and CAV2. If verified in a larger number of tumo...
Researchers identify protein promoting vascular tumor growth
...e University medical researchers determined that a protein
called MCP-1 "recruits" macrophages to the vascula... This means that therapies to eliminate the MCP-1 protein
could be a key to healing or preventing the tumors and possibly others in which MCP-1 is expressed....
UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
...vine researchers have successfully targeted an HIV protein
that has eluded existing therapies. Researchers targeted Nef, a protein
responsible for accelerating the development of acquired immunodeficiency syndrome, or AIDS. Nef was...
Spun from bone
...e and enamel microstructure is attributed to a key protein
in enamel that molds crystals into strands thousan...rs; bone is 35 by 25 by 4 nanometers. But how that protein
achieves this feat of crystal-strand shape-shifting has remained elusive. Today, scientists have rep...
Master of antimalarial resistance
...works by blocking this detoxification process. The protein
produced by the pfcrt gene is located in this digestive vacuole and may act as its gatekeeper. In chloroquine-resistant malaria, mutations in pfcrt may encourage chloroquine to "leak" out of the vacuole before it has a chance to stop the heme detoxif...
Pollutant causes delayed flowering in plants
...lution." Such biochemical pathways are networks of protein
enzymes that make up the signaling machinery that controls the flowering process. "While our work is very much at a very detailed molecular level, I would bet that these findings have large-scale ecological implications regarding the effects of air p...
No role for simian virus 40 in human pleural mesotheliomas
...MSKCC investigators searched for SV40 DNA, RNA, or protein
in frozen tissue samples from 71 human pleural mesotheliomas. According to the study, the methodology used by most researchers for the detection of SV40 DNA is associated with a high risk of false positive results. Therefore, the authors propose that...
Researchers ID chlorophyll-regulating gene
...d the PIF1 gene because it binds to phytochrome, a protein
that is triggered by light and that controls a plant's growth and development. The researchers disabled the PIF1 gene in the species Arabidopsis thaliana, a mustard plant, and compared the mutant seedlings with a control group of normal plants. ...
Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
...stery of how slight mutations in the shape of this protein
can make it resistant to the antibiotics called su...created images of the loops and helical ribbons of protein
making up this DHPS. In addition, they created images showing how certain small enzyme mutations all...
University of Alberta researcher looks for clues to mysterious disease
...ply her work. Scientists already know that the A-T protein
(ATM) is fundamental to repairing DNA damage so she and her research team are studying ATM mutants, which behave as cells do when they are damaged. In a recent issue of the journal, "Current Biology," Campbell describes how they examined ATM mut...
A novel, safer strategy for regulating gene expression
... template that carries instructions for making the protein
encoded by that gene. When the ribozyme cuts itsel... allows the gene to turn "on" and make the desired protein
such as a hormone or growth factor needed by the body. "Perhaps the most exciting aspect of the new...
Study explores gene transfer to modify underlying course of Alzheimer's disease
...the density of amyloid plaques (which are abnormal protein
deposits in the brains of patients with Alzheimer's disease), and loss of synapses in the brains of Alzheimer's disease patients. Alzheimer's disease is a common disease in aging, currently affecting approximately 4.5 million Americans. The number ...
Environmental decontamination, greenhouse gases, and the genome of a methane-loving bacterium
...ns and other persistent pollutants, and to produce protein
for animal feed. ...
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