Tag: "proteins" at biology news

Allergy And Asthma-Exaceberating Mites, Molds And Pollens On The Rise Due To El Niño . . . La Niña

...ecially amongyoungsters who may be allergic to the proteins found in the saliva, droppingsand remains of cockroaches. Asthmatic children who are allergic to cockroachesare four times more likely to go to the hospital and twice as likely to go toemergency rooms than other asthmatics, according to a study repor...

Dismantling Dangerous Genetic Codes With A Faster, More Flexible RNA Mimic

...tion as a catalyst. It had been thought that only proteins couldserve as biological catalysts, or enzymes. Bashkin's co-author of the Chemical Communications paper, Andrew T. Daniher,Ph.D., is now working for Cech in Boulder, Colo. "None of this would have been possible without the talented group of graduate...

Scientists Discover New Players On The Gene-Activation Team

...rge HAT complexes containing betweenten and twenty proteins each, which they describe in the Cell and Naturepa...h areknown to bind to another very large system of proteins known as TFIID,which is important for telling the RNA polymerase where to start copyinga gene," Work...

Antisense Therapy Prevents Burkitt's Lymphoma In Mice

...gene so that they can no longer generate excessmyc proteins that lead to uncontrolled blood-cell proliferation and cancer. Dr. Wickstrom notes that antisense therapy currently is being studied inclinical trials by some researchers. In his newly published book, "ClinicalTrials of Genetic Therapy with ...

Blindness Linked To The Cytoskeleton?

...e genes involved in retinitis pigmentosa encode proteins from the so called ‘phototransduction cascade’, a complex biochemical mechanism which transforms the initial light stimulus to a chemical signal. The latter accomplishes the communication of the photoreceptor cells with the neur...

Subtle Changes In Brain Receptor Gene May Have Significant Consequences For Addiction

...beta-endorphin, amember of the endorphin family of proteins that can numb pain, create feelingsof euphoria or increase energy, which opiates and other drugs of analgesia andaddiction do as well. The findings, reported by researchers from The RockefellerUniversity, Indiana University School of Medicine and Uni...

University Of Kentucky Chandler Medical Center Researchers Identify Protein That May Cause Nerve Cell Death In Alzheimer's Disease

...activated that encode "killer proteins," and these proteins signalcells to begin dying. The identity o...n of events. Once set into motion, other genesand proteins help trigger the "switches" to signal cell death. Mattson andRangnekar continued to pursue other fa...

Clockwork Clues Determined

...in the human brain, a low point for key timekeeper proteins could be just before dawn, corresponding to the temperature nadir for healthy adults. Moreover, the asynchrony between light and temperature cycles may be significant for organisms in temperate regions, particularly in spring or fall when environmen...

University Of North Carolina At Chapel Hill Scientists Find Breast Cancer Gene Required To Correct Certain GeneticDamage

... damage to active genes, which continuouslyproduce proteins critical to cell function, are repaired more rapidly thandamage in inactive or less active genes. "So the cell has prioritized which regions of the genome, or total setof genes, it wants to fix first and does it through transcription-coupledr...

Team Of Max Planck Scientists Elucidates Structure Of A Protein Segment Involved In 'Von Recklinghausen Neurofibromatosis'

...in tumors is the inability of the resulting Ras proteins to cleave GTP efficiently, i.e. to turn off the...eurofibromin, there are other GTPase activating proteins specific for Ras; in living organisms, it is indeed common that identical processes are carried o...

Vertex Researchers Report Three-Dimensional Atomic Structure Of JNK3 Enzyme; Report In Structure

...gs to the MAP Kinase family of enzymes, a group of proteins that helpto transmit signals from the surface of cells to the nucleus, allowing cells torespond to their environment. Pharmaceutical industry interest in JNK3 stemsfrom animal studies that implicate JNK3 in neurological diseases such asepilepsy. Ge...

New Evidence Shows How Some Flu Viruses Become Lethal

...different organs. Their discovery concerns proteins on the virus' surface that allow thevirus to attac...are never the same threat each year. Their surface proteins normally undergo slight changes, called "drift," which requires new vaccines to be developed to prot...

Scientists Discover How Influenza Virus Becomes More Deadly

...s group Astreptococci, contain plasminogen-binding proteins that make it easier for thesebacteria to infect ti...g protein. It is highly likely, hesays, that such proteins will be found in other pathogenic viruses as well. NIAID is a component of the National Institutes o...

Ancient "Jumping DNA" May Have Evolved into Key Component of Human Immune System

...r recombination-activating genes 1 and2), code for proteins that promote this genetic recombination. The Schatz teamhas found that RAG1 and RAG2 work together as a transposase, an enzyme thatsnips pieces of DNA out of one location in a chromosome and transposes thesepieces elsewhere. This ability to slice and...

University Of Texas Southwestern Researchers Find Genetic Switch That Explains Effect Of Exercise On Muscles

...is effect." The study provides evidence that three proteins called calcineurin, NFAT(Nuclear Factor of Activat... factors act in concert to control theabundance of proteins found in slow, oxidative skeletal-muscle fiberscharacteristic of highly fit endurance athletes. Whe...

Enzyme's Structure Yields Blueprint For Antibiotic Resistance

...s also providesan important clue to understand how proteins accomplish life's functions. Burleyexplains that although there are some 100,000 human genes, they produce onlyabout 2,000 basic protein structures. Slightly different surfaces give theproteins their unique chemical properties and abilities, but in m...

Structure Of Enzyme Involved In Gentamicin Resistance Revealed For First Time

...tic-resistance enzyme reveals how remarkablysimple proteins can present life-threatening problems for critical...uctural Biology. The enzyme belongs to a family of proteins called aminoglycosideN-acetyltransferases (AATs). AATs catalyze the addition of molecules calledacet...

Penn Researchers Prove "Short-Cut" Function Of Myelin Sheath Channel: BetterUnderstanding Of Myelin Should Lead To Therapies For Neuropathies

...een discovered forconnexin32. One group of mutated proteins can still form functional gapjunctions, but it remains to be seen how these result in inherited neuropathies.In general, though, as the myelinating cells break down due to these mutations,they impart pathological changes onto the axon. "The mechanism...

Virus Linked To Causing Enlarged Hearts In Children With Certain Genetic Makeup

...esponding in an unusually aggressive way tocertain proteins called antigens. Antigens are located in viruses, and theytrigger the cells in the body's immune system to respond. The children's genetic background made them more susceptible to this virus,which led to an overreaction of the normal immune system r...

New Evidence For Growth Factor Role In Crohns Disease

...sion, inhibitors of its action such as IGF binding proteins (IGFBPs) maybe used therapeutically to help prevent fibrosis and its complications. An estimated six new Crohn's disease cases per 100,000 population occur in mostdeveloped countries, including the U.S., each year. Peak ages are in adolescenceand ea...

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