Drug prevents chemotherapy-induced hearing loss, study finds
...blished in the journal Hearing Research found that rats treated with N-acetylcysteine, or NAC, did not suf...h as gastrointestinal and renal toxicity. In fact, rats given NAC 15 minutes before chemotherapy exhibited less overall toxicity, shown as weight loss, seve...Long-term heart damage may result from constant confrontation and defeat
...s stress. However, it was shown recently that rats intermittently exposed to an uncontrollable social...ne animal study has stated that conflict among the rats did not significantly affect heart structure. On the other hand, another animal study reported that......ly explored. Now, a long-term study involving male rats has found that a protein intake of three times the... Methodology This study used male Wistar rats that were administered either a no protein diet or a high protein diet for six months. Detailed bod...JCI table of contents, 1 July 2004
...mia" leads to in vivo insulin resistance in normal rats AUTHOR CONTACT: Jerrold M. Olefsky University of California, San Diego, La Jolla, California, USA. Phone: 858-534-6651; Fax: 858-534-6653; Email: jolefsky@ucsd.edu View the PDF of this article at: https://www.the-jci.org/press/20785.pdf...Gene alteration points to longevity, thinness
...ve identified this longevity gene in humans, mice, rats and zebrafish as well as C. elegans. Armed with a new $605,000, three-year grant from the National Institutes of Health's Institute on Aging, the researchers want to know the activity level that optimizes longevity and find compounds to control that ...In the obese, metabolic adaptations post-weight loss lead to regaining of shed pounds
...energy and fuel utilization in these obesity-prone rats throughout five stages of obesity development, tre...study design consisted of placing 13 obesity-prone rats on a high fat diet for a period of 16 weeks to promote the development of obesity. These obese rats ...Birds show superior listening skills
...rofessor at the University of Alberta. "Humans and rats are weak by any standard, and they're just awful w...hes, white throated sparrows, and budgerigars) and rats were given food rewards. Sturdy said humans actually perform fairly well in tests of relative pitch...Study: Artificial sweetener may disrupt body's ability to count calories
... or smell food. Davidson and Swithers propose that rats learn a similar relationship between the taste or ... on two studies. In the first study, two groups of rats were given two different sweet-flavored liquids. In the first group, both liquids were sweetened wit...Researchers recommend new approach to combat drug-resistant staph infections
...irulent by inhibiting a target protein (TRAP). All rats included in the group with RIP-soaked grafts and also systemically administered RIP showed no evidence of graft infection, indicating 100 percent protection. In addition, none of the animals had clinical evidence of drug-related adverse effects. This...Newly grown kidneys can sustain life in rats
... new kidneys were able to successfully sustain the rats for a short time. "We want to figure out how to gr... of Renal Diseases and leader of the study. "These rats lived seven to eight days after their original kidneys were removed, long enough for us to know that...Existing drug may prevent brain injury and seizures in newborns
... given immediately after a hypoxic-ischemic event, rats were protected from oligodendrocyte injury and showed fewer neuromotor abnormalities than the untreated rats. The researchers went on to show that topiramate does not affect the normal development of oligodendrocytes. "The finding that treatmen...Fat cells could provide the key to a longer life
...Biology, who led the study, explains: "Studies in rats have shown restricting diet doubles lifespan but the pay off is reduced fertility. Elsewhere, groups have looked at mutations such as the DAF-2 gene in C. elegans, which can also double life span or reduce fertility depending on what stage in life t...Albany high school student adds to understanding of breast cancer gene
...he gene, while humans and rodents such as mice and rats have less consistency in gene sequence--about 65 p... were the same sites conserved among humans, dogs, rats and mice. Furthermore, Figge documented that among the conserved amino acids that make up the BRCA-1...Nanoparticles illuminate brain tumors for days under MRI
...ross the blood-brain barrier to the brain cells of rats and could be seen with MR. "Once we realized that iron oxide nanoparticles had unique pharmacology and a very long half-life in blood, we thought this might be a good imaging modality, not just to see where viruses went, but where inflammatory regio...Combination therapy dramatically improves function after spinal cord injury in rats
...ransplanted Schwann cells into the spinal cords of rats in a way that bridged the damaged area. The researchers also gave the rats a form of cAMP and a drug called rolipram, which prevents cAMP from being broken down. Treatment w...Artificial light-dark cycles expose circadian clocks at odds with each other
...icial day-night cycles. For the study, a group of rats was exposed to artificially created 22-hour days, with 11 hours each of light and dark. With the shortened 22-hour days, the researchers found that what normally is daytime activity began to expand into the artificial night hours, and that enabled th...Muscle-derived cells and gene therapy may cure for post-prostatectomy erectile dysfunction
... into the corpus cavernosum or cavernous nerve of rats at the time of cryo-injury to the nerve. The caver...ve. On electrical nerve stimulation, nerve-injured rats that expressed the viral vector experienced an increase in intracavernous pressure. Injection of S...Latest findings on PCBs to be subject of June workshop at Illinois
...a-Champaign; 2. Auditory and motor impairments in rats exposed to PCBs and MeHg during early development, John Widholm, University of Charleston; 3. GABA disorder, PCBs, ethyl mercury and autism: Possible interplay of genes and environment, Isaac Pessah, University of California-Davis; Break 4. Are fi...Analysis uncovers critical stretches of human genome
...-pairs in a row, that were identical among humans, rats and mice. Statistically, the likelihood that a sequence of this length would appear unchanged among all three genomes by chance was infinitesimally small. The results, said Haussler, were startling. The comparison of the three genomes revealed 481 s...Gene therapy reduces drinking in rats with genetic predisposition to 'alcoholism'
...k showing that gene therapy can reduce drinking in rats trained to prefer alcohol, scientists at the U.S. ...ry have used the same technique to cut drinking in rats with a genetic predisposition for heavy alcohol consumption. The findings, along with additional res...