Tag: "reactivation" at biology news
Cannabis may help combat cancer-causing herpes viruses
... before they burst out and begin replicating. This reactivation
of the virus boosts the number of cells infected t...logist Peter Medveczky, MD, found that this sudden reactivation
was prevented if infected cells were grown in the presence of THC. While cells infected with a mouse...
The telomere crisis: A crucial stage in breast cancer
...e that telomere crisis in hyperplasia, followed by reactivation
of telomerase, leads to carcinoma in situ -- and t...echanisms, for example, or that prevent telomerase reactivation
or that poison cells in which telomerase is already active. Some of these possible preventive agents...
AIDS drug helps to keep HBV at bay during chemotherapy for breast cancer
...ong Kong have discovered a way to help prevent the reactivation
of the hepatitis B virus in women who are being tr...rus. These patients are at risk of developing HBV reactivation
during chemotherapy, which is a well-known complication resulting in varying degrees of liver damage...
Novel approaches to current cellular therapies continue progress toward disease prevention
...lowing the transplant, 22 experienced repeated CMV reactivation
approximately 18 weeks after transplant. Six patients developed pneumonia from the CMV disease, and five of the six subjects died. Thirteen out of 23 recipients in the control group displayed Aspergillus antigen activity, which persisted for severa...
FDA approves Raptiva (efalizumab) for chronic moderate-to-severe plaque psoriasis
...o selectively and reversibly block the activation, reactivation
and trafficking of T-cells that lead to the development of psoriasis symptoms. In clinical studies, RAPTIVA demonstrated a rapid onset of action in the reduction of symptoms associated with psoriasis, in some patients within four weeks of initiating ...
PET scans used to determine progression of HIV infection
...h latent virus could be reactivated would be left, reactivation
might not occur for months or years after removal of the active nodes, thereby allowing extended interruption of treatment for the disease. Despite the systemic nature of HIV infection, the sites of viral replication appear remarkably restricted to l...
Pancreatic cancer linked to errant reactivation of embryo cell pathway
...injury or inflammation of the pancreas. "We think reactivation
may be a first step in initiating pancreatic cancer, well before the onset of any alterations to the pancreatic cells' genetic material," says Steven D. Leach, M.D., Paul K. Neumann Professor in Pancreatic Cancer at the Sidney Kimmel Comprehensive Ca...
X-Rays yield mechanism of Alzheimer's drug
...at inhibition was almost irreversible, with little reactivation
over a period of days. To explain this at the molecular level, the scientists took snapshots of rivastigmine bound to AChE by projecting X-rays onto crystals of rivastigmine combined with AChE, and observing the X-rays diffraction patterns. They the...
Stanford researchers identify genes involved in tuberculosis latency
...n the upper lobes of the lung, are a wake-up call; reactivation
of the dormant bacteria leads to clinical symptoms...nority of latently infected people ever experience reactivation
of the tuberculosis bacteria, the likelihood of reactivation
approaches 100 percent in people living...
The biology of induced memory
... Nader. "Surprisingly, the effect occurred even if reactivation
was delayed for 45 days after training, a time when declarative memory is independent of the hippocampus. In fact, we found that if you lesion the hippocampus 45 days after conditioning, there is no effect. Therefore the memory of the context has to...
Caught sleeping: Study captures virus dormant in human cells
...d Shenk. Women who become infected or experience a reactivation
during a pregnancy risk passing the virus to the fetus, which can lead to birth defects, including deafness and developmental disorders. Between 50 and 85 percent of Americans become infected with cytomegalovirus by age 40, according to the National ...
Space Research Briefs - Sept./Oct. 2001
...e been linked to the development of cancer. "Viral reactivation
poses health problems for the individual and the e...ways to regulate resistance to infection and viral reactivation
and to decrease the possible risk of cancer."...
Tipsheet: April journals of the American Society for Microbiology
...ls, the majority of cases are thought to be due to reactivation
of latent disease acquired decades earlier. In vi...d here may also have applications to prevention of reactivation
tuberculosis in the elderly." (J.V. Brooks, A.A. Frank, M.A. Keen, J.T. Bellisle and I.M. Orme. 20...
Instant replay: study finds potential mechanism for building long-term memory
...nly this time it's due to some kind of spontaneous reactivation
mechanism." This observation could yield insights into the much broader question of how the brain maintains a continuity of knowledge and memories over a lifetime despite the constant turnover of molecules and proteins. The insight also may one day h...
New study finds link between decline in the city's TB rates and intensified control programs
... infections in that disease can becaused by either reactivation
of latent infection acquired years earlier or as aresult of recently acquired infection followed by rapid progression to activedisease. TB cases due to recently acquired infection--or clusteredcases--indicate the amount of transmission that is occur...
Nationwide Study Finds HIV-Positive Women Are At High Risk For Cervical Human
...d HPV disease amongHIV-positive women results from reactivation
or persistence of previouslyacquired HPV rather than recent acquisition of the virus. The study was conducted before protease inhibitors were in widespread clinicaluse. However, it is possible that HIV-positive women who gain a new lease onlife thro...
Severe Pain Following Shingles Safely Relieved In Clinical Trial Of Anti-Convulsant Drug Gabapentin
...aused by the virus Herpes zoster, results from the reactivation
ofthe chickenpox virus and attacks more than a million people in the United Stateseach year. While the shingles rash and pain eventuallysubside in most people, about 10 to 15 percent experience continued severe painknown as postherpetic neuralgia, or...
Social Stress Causes Dormant Herpes Virus To Resurface In Mice
..., resulted in a significant reactivation
of the herpes virus," he said. While 40 percent of mice showed herpes reactivation
when faced with social stress, only 8 percent of the mice who were restrained...
Denatured Proteins Rescued By Trio Of Chaperones
...enother heat shock proteins from yeast were added, reactivation
of luciferase wasobserved. Lindquist and Glover pinpointed two heat shock proteins that were observed tointeract with Hsp104-Hsp40 and Hsp70. When these chaperones were added to theaggregated luciferase together with Hsp104, there was a pro...
New Herpesvirus Receptor Discovered That Allows Entry of Both Herpes Simplex-1And -2 And Animal Herpesviruses Into Human Cells
... nerve cells and persist indefinitely withperiodic reactivation
of the virus. Consequences of viral replication includecold sores and fever blisters, similar lesions on the genitalia, cornealdestruction, encephalitis and severe disease in newborns. The virus can bind tomany types of human cells but is capable of ...