Key Asthma And Allergy Molecule Pictured
...st cells anchors immunoglobulin-E,an antibody that receives allergens and triggers the mast cells to producehistamine, leukotrienes and other broadly-acting effector substances that leadto the itching, sneezing and congestion of allergies -- and the life-threateningrespiratory distress of asthma and anaphylac...Scientists Discover Function For Type III TGF-Beta Receptor
...een a mystery why only a small population of cells receives the signalto change. "Their neighbors never undergo this epithelial-mesenchymal transformation,"Barnett said. "We wanted to know why, so we asked what cell surface receptorsare found on the cells that transform but are missing on the cells that do n...Stanford Chemical Engineer Chaitan Khosla Receives Alan T. Waterman Award From NSF
...forefront of science orengineering. The recipient receives a medal as well as a $500,000 grant overthree years for scientific research or advanced study in any field of science orengineering....Functional Arteries Grown From Cells Using Novel System That Simulates Fetal Environment
...e arteries are fromthe same animal that ultimately receives the artery, the culture process maychange them. Further studies will need to be conducted on how the body willreact to these cells, which tend to be more immature than their nativecounterparts. The most obvious initial use of bio-engineered vessels ......n links to receptorsnear the cell membrane when it receives an external signal to move. Then theorganizing protein recruits and mobilizes the cell's motility protein, actin.The cell will then move in the direction that corresponds to the buildup ofactin. The researchers found that in addition to its chemical ......vestigatorsdetermined that when the DAF-2 receptor receives a signal from itsinsulin/IGF-like hormone, it inhibits the activity of the DAF-16 gene, whichnormally signals cells to continue to live long and productively. When theDAF-2 gene is mutated, DAF-16's activity increases, and the animal remainsactive a...Procedure, new apparatus may allow relief from incontinence
...s to a cuff, which surrounds the anal canal. If it receives FDA approval, the prosthesis will become more widely available,and a seldom-discussed but common problem may be solved for some people. "Incontinence related to neurological deterioration is most often seen in theelderly but can also occur in younger...UI researchers advance potential, potent way to stimulate human immune system
... by the UI Diabetes and EndocrinologyCenter, which receives grant support from the NIH....Growth factor may determine who grows new blood vessels that protect against heart attacks
...ctor (VEGF) aperson produces when the heart muscle receives insufficient oxygen -- acondition called hypoxia. The Israeli team studied 51 patients, all of whom had a blockage of 70 percentor greater in at least one coronary artery. The patients underwent diagnosticangiography -- an X-ray that shows where a ...Rescuing brain cells in stroke patients from the brink of suicide
...' and just atiny percentage of patients ultimately receives them. There are no drugsapproved for use in humans to help save the cells in the siege that follows in abroad area known as the penumbra, the area surrounding the initial site ofstroke. "Patients who arrive at the hospital too late to be cand...Seeing one weapon from a food-borne pathogen
... plan to lookmore closely at the messages the cell receives when invasin binds to itsintegrin receptors. They are also interested in the process by which thisbinding triggers uptake of the bacteria by epithelial cells in theintestine. Meanwhile, the next step for Bjorkman and her colleagues is to determine t...NIH grantee Günter Blobel wins Nobel Prize for protein signaling discovery
...lular organelle,the nucleus. Dr. Blobel currently receives support from NIH's National Centerfor Research Resources for the identification of the proteins that make up thenuclear pore complex, the structure through which this bidirectional traffictakes place. Dr. Blobel is the John D. Rockefeller, Jr. Profes...Science and Amersham Pharmacia Biotech award Young Scientist Prize
... is selected from the pool of regional winners and receives $25,000. Velculescu will be honored together with four other regional winners on 9 December at Uppsala University in Sweden, in a ceremony that coincides with the Nobel Prize festivities. For his thesis, Velculescu developed a method known as SAGE (...Fox Chase Cancer Center's Joseph Testa receives 1999 Irving J. Selikoff Award for Cancer Research
...icans who develop mesothelioma every year. Testa receives support for his research from the Mesothelioma Fund established in 1992 by Local 14 of the International Association of Heat and Frost Insulators and Asbestos Workers in partnership with the Insulation Contractors Association. The membership of each...Smell, taste may influence lifespan of the roundworm C. elegans
... hormonesystems in humans. When the DAF-2 receptor receives a signal from its insulin/IGF-like hormone, itinhibits the activity of the DAF-16 gene, which normally signals cells to continue to live long andproductively. When the DAF-2 gene is mutated, DAF-16's activity increases, and the animal remainsactive ...New institute formed to distribute human stem cells
...the new NIH guidelines occurs, any laboratory that receives federal support is prohibited from working with the cells. The information gained from growing these cells and studying them is necessary to move a technology with huge potential from the laboratory to the clinic, Hinshaw says: "Now we can develop a ......ific locations within the brain. The patient then receives a CT or MRI scan of the brain and the surgical team makes its final decision for location of cell implantation. Concurrently, the University of Pittsburgh Immunologic Monitoring and Diagnostic Laboratory team thaws the human neuronal cells that...... less radiation than the annual dose an individual receives from the everyday environment in the United States. The University of Pittsburgh study covered the years 1979-1992. For demographic and lifestyle data on the individuals living in the TMI area, researchers used information collected by the Pennsylva...... In addition, the immune system of any patient who receives transplants rejects the foreign cells, unless the recipient's immune response is suppressed. Unfortunately, current therapies that suppress the immune system target not only the transplanted organ or cells but also generally reduce immune responsive...Northwestern scientists shed new light on neurodegenerative diseases
...roper shape. In this delicate process, the protein receives its folding instructions from its amino acid sequence and is assisted by a class of proteins known as heat shock proteins or molecular chaperones that function to prevent misfolding, or, in the case of already misfolded proteins, to detect them and p...