Tag: "receptor" at biology news

The future of HIV therapeutics is brightening, according to Gladstone Institutes Director

...ng these therapeutics are drugs known as chemokine receptor antagonists that interfere with HIV's ability to bind to CCR5, one of two key surface receptors needed for the virus to penetrate the cell. Although these HIV co-receptors were identified only seven years ago, basic studies performed by both GIVI inv...

University of Pittsburgh receives $10 million grant for head and neck cancer

...n of head and neck cancer, epidermal growth factor receptor (EGFR) and members of the G-protein-coupled receptor (GPCR) family. While both types are over-expressed in head and neck cancer, preliminary studies sugg...

Marathoning mice could have Olympian effects on obesity

...d team discovered that activation of the switch, a receptor called PPAR-delta, increases the rate at which the... By expressing genes for an activated form of the receptor PPAR-delta, we created a mouse that could, compared to normal mice, run marathons, said Evans. The a...

Engineering endurance: The future of the Olympics?

...on. Evans and colleagues suspected that a nuclear receptor called PPAR--a major regulator of fat burning in fat tissue that is also prevalent in skeletal muscle--might be involved and genetically engineered mice to express an activated form of the PPAR protein in skeletal muscle. The transgenic mice showed m...

New clues to hereditary blinding disease found

...ty to successfully bind zinc to rhodopsin, a light receptor protein in the eye, can trigger retinitis pigmentosa (RP), a degenerative disease that leaves many patients legally blind by the age of 40. The findings parallel similar progress in harnessing essential trace metals in the body to treat several neu...

New 'clock gene' uncovered

...imilar in amino acid sequence to the retinoic acid receptor genes, although they do not have the same function and do not bind to retinoic acid. (They are called orphan receptors because it is not known what activates them). The Flick of a Switch Rora is a gene that produces a transcription factor -- a ...

New model can aid in understanding immune system diseases

...ted with Epstein-Barr because they do not have the receptor for this virus. What we have done is express in the mouse the most important transforming protein that is involved in the virus in humans," said Bishop, who also is associate director for basic science research at the Holden Comprehensive Cancer Cent...

JCI table of contents, 16 August, 2004

...argeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis AUTHOR CONTACT: Martin C. Carey Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA Phone: (617) 732-5822; Fax: (617) 730-5807; E-mail:...

Ovarian cancer sheds tumor suppression with loss of estrogen receptor

An important receptor for estrogen in ovarian cells has been shown to su..., the number of these receptors--known as estrogen receptor beta (ER beta)--diminishes, encouraging these tumors to advance toward malignancy and metastasis. Th...

Schizophrenia gene variant linked to risk traits

... gene identified in this study makes the glutamate receptor (GRM3) which is responsible for regulating glutamate in synapses--spaces in between brain cells--where chemicals like glutamate transfer information from cell to cell. The amount of glutamate remaining in the synapse may have a downstream impact on c...

Excess thyroid hormone harmful to fetus

... In persons with a mutation of the thyroid hormone receptor gene the hormone was less effective. People with the mutation produce more thyroid hormone than normal but they do not experience the anxiety, weight loss or elevated heart rate usually caused by such excess. The genetic defect is transmitted as a ...

Brain's reward circuitry revealed in procrastinating primates

...itute of Mental Health (NIMH). "The gene makes a receptor for a key brain messenger chemical, dopamine," exp...re was also reason to suspect that the dopamine D2 receptor in this area might be critical for reward learning. To find out, the researchers needed a way to tem...

Scientist who discovered Sly syndrome finds new research path to explore for treating the disease

...elivery molecule, which is the mannose-6 phosphate receptor (M6PR), but does not place it on the surface of the blood-brain barrier where it can transport enzyme. Instead the M6PR stays inside the blood-brain barrier cell. "We've got to convince the blood-brain barrier to turn the delivery system back on." Th...

Alterations in vitamin D receptor gene increase prostate, breast cancer risk

Subtle differences in the receptor for vitamin D reverse the anti-cancer action of th...men who carried specific versions of the vitamin D receptor gene, or VDR, not only experienced increased risk for this cancer but may also be more prone to deve...

Molecular therapeutics advance fight against brain cancer

...stigating a variant of the epidermal growth factor receptor that is present in many primary glioblastomas to better understand the development of malignancy in the brain and how it relates to cancer cell division, survival, and movement....

Activated signaling pathway may predict lung cancer patients' response to gefitinib

...g that interferes with the epidermal growth factor receptor (EGFR) pathway, is active in approximately 10% of NSCLC patients in whom standard therapy has failed. Although earlier studies have found that the expression of EGFR alone does not predict whether a patient will respond to gefitinib, there are many s...

Two-pronged attack targeting EGF receptor hinders cancer cell growth

Hitting the epidermal growth factor receptor (EGFR) both high and low with a combination of dru...s the EGFR high, binding to a specific site on the receptor outside the cell membrane. Erbitux blocks the receptor from responding to extracellular signals that...

Misfiring proteins tied to inflammation and sick feeling of type 2 diabetics

...ion, triggered by hyperinsulinemia, of the insulin receptor substrates. This phosphorylation, Freund said, "im...d looked at the signaling abilities of the insulin receptor substrate 2, and, lo and behold, we indeed saw reduced signaling function." Freund's co-authors on t...

Scientists discover new intricacies in how ulcer bugs stick to stomach

...ceptor. In humans with different blood types, this receptor either stands alone (blood type O) or contains additional sugars (blood types A and B), changing the shape of the target babA seeks to bind. "Most human populations have a mixture of people with blood types A, B and O. When the bacteria spread...

Heat and exercise alone may not determine how much we sweat

...alized detector for a particular type of stimulus; receptor cells provide the sensor neurons, responsible for responding to the stimulus. Receptors can be grouped according to the kind of energy that they are most sensitive to, whether it is chemical, mechanical, light, thermal, electrical, or magnetic. The...

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