Malaria called failure, puzzle and challenge
...der development, the PAHO magazinenoted. One is a recombinant protein vaccine developed by SmithKline Biologicalsthat would prevent the malaria parasite in its infectious stage from entering ordeveloping within liver cells of human beings, thus blocking the severe andlife-threatening consequences of malaria in ...Scientific team identifies gene critical in embryonic development
...functions of genes by deleting them frommice using recombinant DNA methods. She then monitors the mice closely todetermine the effects of the deletions. The mice are called "knock-out" mice,because specific genes have been knocked out. In this research project,conducted while she was a researcher at the National...Report in Science on x-ray crystal structure of matrix Metalloproteinase-2 (MMP-2)
...ny hasalso developed methods for the production of recombinant basal lamina proteinsfor use in wound repair and advanced tissue regeneration protocols.......op the uncontrolled cell division in cancer. Using recombinant DNA techniques, Bernstein cloned hCdc5 in 1997 and showed thatit is a novel human protein involved in the division of human cells. Since then,he and his research team have shown that it binds to DNA and acts as atranscription factor -- it regulates g...Nobel Laureate David Baltimore To Speak To NYU Undergrads
... national policy-making on issues such as AIDS and recombinant DNAresearch. The Jurow Lecture was endowed by NYU alumnus Irving H. Jurow to bring a leadingintellectual or cultural leader to NYU's undergraduate community. The inaugurallecture was given by Stephen Jay Gould. Last year's lecture was given by Davi...Researcher Awarded Patent For System To Fight Multiple Diseases
...oli. One purpose of these studies was to developa recombinant vaccine that would induce anti-streptococcal immun... The technology currently is being used to develop recombinant vaccinesto prevent or therapeutically treat infections due to Heliobacter pylori, whichcauses ulcers...Engineered Bacteria Scavenge Heavy Metals
...ts that other processes do not offer: -- Cornell's recombinant bacteria take over where other processes, such asion-exchange resins or bioabsorbents, leave off by removing heavy metals fromvery dilute solutions and reducing the contamination to the lowest detectablelevel -- less than 10 parts per trillion. -- T...Researchers Discover Genetic Mutation For Rare Form Of Dwarfism
...have been treating a subset of the population with recombinant humangrowth hormone. Each patient showed a brisk increase in speed of growth. Levine and his colleagues are continuing their search for the cause ofgigantism. The work was supported in part by the National Institutes of Health andthe......ivate the dangerous parts of the virus andthen use recombinant techniques to load genes onto the virus. These recombinantviral vectors can then safely ferry therapeutic genes to their target tissues.)Using iron particles the same size as viruses, the Oregon researchers noticedthat some agents crossed the endothe...Multicomponent Malaria Vaccine Shows Promise in Laboratory Tests
...1 different P. falciparum proteins to forma single recombinant protein, which they used to immunize rabbits. Each of the21 segments, or peptides, was selected because it was recognized by the immunesystems of people with malaria, as shown in earlier studies. Furthermore, thepeptides targeted different branches....... The answer was yes, determined bysubstituting a recombinant protein containing solely this extra-cellular portionof CD4 (provided by collaborators at SmithKline Beecham) for the CD4-positivecells. When the CCR5-bearing cell was mixed with the soluble CD4 (sCD4) protein, theresearchers found clear evidence of...Gene Therapy Incorporates Molecular Rheostat For Controlled, Long-Term Drug Delivery
...ctively with the gene forerythropoietin, or Epo, a recombinant protein that stimulates red blood cellproduction and is used to treat anemias, and the genes for a transcriptionfactor complex able to regulate Epo. ARIAD investigators had previously shown that this particulartranscription factor could be sw...Biotech Creates New Solutions And New Problems
Since recombinant DNA techniques were first developed by University ...found shift in the ownership of life forms and the recombinant DNA toolsneeded to manipulate them. These changes present problems both for growers ofmajor crops, w...Allelix drug increases bone density and content in women with osteoporosis
...ical trial demonstrating that its compoundALX1-11, recombinant human parathyroid hormone significantly increases ...s 98 percent. Allelix's ALX1-11 is a proprietary recombinant version of human PTH and isidentical to the naturally occurring protein produced by the parathyroid ......s, suggests that gene-transfertechnology using the recombinant defective virus known as AAV (adeno-associatedvirus) may eventually prove feasible for gene therapy in human brain disorderssuch as Parkinson's disease and epilepsy. A report of the new study appears Dec. 2 in the journal Gene Therapy. The successf......sion inmaternity wards. With the advent of recombinant DNA technology in the early 1970s.researchers gained the ability to insert or delete specific genes in manyorganisms and thus learn the gene's function. But the genome of HSV was too bigfor manipulation in the laboratory, so Dr. Roizman's group indu...... conducts research and development in thefields of recombinant technology, gene therapy, vaccines, small moleculediscovery, and genomics.......t and destroy pathogen-infested cells. Previously, recombinant poliovirus vectors had only been demonstrated to i...ived, it may well be possible, he said,to create a recombinant poliovirus with an antigen that would prompt a CD8T-cell response to cancers that actually affect hu...