Tag: "refractory" at biology news
Researchers Identify Protein Critical To Urine Concentration
...nt of diseases associated with fluid retention, or refractory
edema, including congestive heart failure and cirrhosis, said the researchers. "If we could inhibit the water channel with drugs," says A.S. Verkman, MD, PhD, UCSF professor of medicine and physiology, "then problems of fluid retention could be effe...
Poison-Eating Bugs Strike Gold
...water completely re-usable by mines that bioleach refractory
ores prior to cyanide gold extraction. Quality water is scarce in WA's gold-producing regions - and any technology which allows us to recycle it will benefit both the industry and the environment." Dr Franzmann says the discovery highlights the...
15 Drugs, Dyes And Other Chemicals Newly Listed As Known Or Likely Human Carcinogens
...chemotherapywith cyclophosphamide in patients with refractory
malignancies treatedwith autologous bone transplantation. Newly listed as Reasonably Anticipated to be Human Carcinogens: AZACITIDINE, a drug used to treat acute leukemia. p-CHLORO-o-TOLUIDINE and its HC1 salt, used to produce azo dyes forcotton, ...
UroGenesys researchers discover new target antigen for prostate cancers
...including the development of metastaticand hormone refractory
disease. By implanting patient-derived tumor samples into immune-deficientmice, the Company is also able to generate a renewable supply of primary and metastatic tissues thatare otherwise difficult to obtain. UroGenesys utilizes these tissues in it...
AVAX Technologies' O-Vax cancer vaccine induces positive immunological and clinical outcomes in patients with advanced ovarian cancer
...inical response in ovarian cancer patients who are refractory
to conventional chemotherapy. The presentation, entitled "Immunological and clinical effects of autologous, hapten-modified vaccine in patients with advanced ovarian carcinoma," offers data based on studies conducted by David Berd, M.D., Professor o...
Millennium's LDP(PS)-341 inhibits growth and induces death of cancer cells, appears to overcome chemotherapy resistance
...anced clinical studies to explore LDP-341's use in refractory
treatment for multiple myeloma and other blood-borne cancers," said Dr. Orlowski. According to Julian Adams, Ph.D., senior vice president, research and development of Millennium, LDP-341's novel mechanism of action and its role in the metabolism of...
Final results of the two Zevalin pivotal trials in radioimmunotherapy for B cell Non-Hodgkin's Lymphoma announced by IDEC Pharmaceuticals
... controlled study of 143 patients with relapsed or refractory
low grade, follicular, or CD20-positive transforme...l of ZEVALIN in 54 follicular NHL patients who are refractory
to Rituxan (i.e., non-responders or patients with time-to-progression of less than six months after ...
FDA approves new treatment, Campath , humanized monoclonal antibody, for patients with B-cell chronic lymphocytic leukemia
...G, Germany (NYSE: SHR), will provide patients with refractory
B-CLL a new treatment option. Campath therapy for.... This approval is good news for patients with refractory
B-CLL. Campath provides a new option for refractory
patients who have no other approved therapeutic...
Cell Genesys reports antitumor activity in Phase I/II GVAX lung cancer vaccine trial
...ne program targets patients with recurrent hormone refractory
prostate cancer and is currently being evaluated in two multicenter Phase II trials. A series of Phase I/II trials was recently initiated utilizing the companys new high-potency GVAX prostate cancer vaccine. Additionally, a Phase I/II trial for GVA...
New, improved drugs could result from first-ever transfer of DNA information from one species of streptomyces to another
...motherapeutic drug that has so far been completely refractory
to genetic manipulation, said Dr. Janet Westpheling, a UGA geneticist and leader of the research team. We anticipate that the ability to get DNA into this strain of Streptomyces will lead to the production of novel bleomycins. Westpheling, ...
New research on safety of intracoronary delivery of adenovector reported in cover story of Molecular Therapy
...strated that germ cells grown in cell culture were refractory
to infection by Collaterals adenovector. To assess the risk of germ line transmission in vivo, researchers used a mouse model to deliver human recombinant Ad5 carrying a germ cell-specific promoter fused to a reporter gene directly into the left ven...
Durable responses reported with Bexxar
... an important new treatment option for relapsed or refractory
NHL patients, and in particular for patients whose...s Analysis of data on 582 patients with relapsed, refractory
low-grade or transformed low-grade NHL who received Bexxar in clinical trials from 1990-2000, by Joh...
Antimicrobial peptides: new weapons to fight infection
...ed for treatment of non-small cell lung cancer and refractory
ovarian cancer. The innate antibiotics of animals were discovered by scientists who were bewildered by the many examples in nature of plants and animals living in apparent harmony with microbes, said Dr. Zasloff. During this era of computer-based ed...
Chemgenex reports use of chemical genomics strategies to advance drug development
...t for solid tumors including glioblastoma, hormone refractory
breast and prostate cancers. Quinamed(TM) down-regulated genes including Jun B, protein kinase C, and EGF protein in human colon cancer cells and in tumors from animal models of colon cancer that treated with the drug. These genes are important to se...
Cell Genesys reports long term survival data in Phase II trial of GVAX prostate cancer vaccine
...toward prolonged survival in patients with hormone refractory
prostate cancer metastatic to bone. In the 34-pat... median survival of seven to 11 months for hormone refractory
prostate cancer patients with bone metastases who are treated with chemotherapy, the current standar...
Study identifies hypertension patients who can benefit from the little used diuretic amiloride
...more anti-hypertensive agents). Nine subjects with refractory
hypertension were prescribed amiloride for a four-...vely activated ENaC in 25 percent of patients with refractory
hypertension. On the other hand, Na+ channel activation was not found in any of the study subjects ...
UC Riverside leads the country with the highest number of 2002 AAAS Fellows
...d to generation of the first transgenic mosquitoes refractory
to plasmodium transmissions. Derek A. Roff , professor of biology. Dr. Roff is an evolutionary population ecologist with wide-ranging interests in population and quantitative genetics, life-history, and the biology and ecology of dispersal and mig...
Honey bee genome being sequenced
...other pathogens. Yet, honey bees remain remarkably refractory
and resistant to disease, Weaver said. Has sophisticated cognitive abilities to maximize foraging success. Honey bees are excellent at associative learning, based on the need to associate a color, shape, scent or location with a food reward. ...
Clinical study reports findings of combination therapy with DOXIL
...noma of the ovary in patients with disease that is refractory
to both paclitaxel- and platinum-based chemotherap... mg/dL give normal dose. Efficacy DOXIL's refractory
ovarian cancer indication was based on the results of three Phase II trials involving patients with ...
KEPPRA international Phase IV SKATE study results show favourable efficacy
... 16-week treatment period in a broad population of refractory
patients, with between one and fourteen partial-on... study, most patients could be diagnosed as highly refractory
- with two thirds of patients having tried a treatment and failed with 3 or more AEDs prior to study...