Researchers determine genetic cause of Timothy syndrome
...utations that interfere with calcium channels that regulate the excitation and contraction of the heart. In defining the precise nature of the molecular abnormality, however, the researchers have also identified a class of drugs that they hope will alleviate the arrhythmia. Timothy syndrome may also cause a ...EMBO Gold Medal 2004 goes to Spanish scientist
... telomeric heterochromatin and the activities that regulate it. Other recent groundbreaking contributions to cancer research include generation of the first telomerase transgenic mice showing them to be tumour-prone; demonstration of interplay between the status of the retinoblastoma family of proteins and t...UT Southwestern biochemist honored with NIH Director's Pioneer Award
...f genes that control the body's internal clock and regulate such processes as sleep, wakefulness and hunger signals. Research in the McKnight lab has recently shown mutations in a class of genes related to these "clock" functions have a broad range of outcomes, from abnormal eating and sleeping patterns to si...New molecular link key to cellular proteins involved in cancer progression, other diseases
...omic material into the nucleus and the other is to regulate processes involving DNA including gene expression, or transcription." In 1975, histone H2A was the first molecule ever described to be ubiquitinated, or modified by the attachment of the protein ubiquitin, but neither the consequence of H2A ubiquitin...16 APS exercise research highlights, from reduced flu mortality to proteomics & obesity
...an expanded analysis of the complex processes that regulate the myogenic progenitor cell and characterize the discrete stages of the muscle repair process. 12.4 Natasha Frank, et al. (Children's Hospital Boston, Mass.) Expression of early developmental genes by human fetal skeletal muscle side population ...Marijuana use could cause tubal pregnancies
...h the action of noradrenaline, a neurotransmitter regulate muscle contraction. Wang, who led the study, has received two Lalor Foundation fellowships supporting research in reproductive biology. Subsequent experiments supported a new concept: the CB1 receptor modulates the release of noradrenaline, which in ...UMaine anthropologist wins Solon T. Kimball Award
...iplines. In helping to identify successful ways to regulate public policy, Acheson has provided insight into "what most of us cultural anthropologists are trying to do to come up with the means that will help us with the problems most of humanity faces," Roscoe adds. Acheson grew up in Augusta and earned a b...Pollutant causes delayed flowering in plants
... plants produce their own internal nitric oxide to regulate flowering, they are also influenced by external concentrations of the chemical. The scientists said that although their findings are basic in nature, they suggest that the massive amounts of nitric oxide emitted as air pollutants from burning fossil ...Researchers ID chlorophyll-regulating gene
...researchers say the ability of plants to precisely regulate production of protochlorophyll was probably an evolutionary development designed to ensure seed survival among higher plants. Primitive plants, such as mosses and some species of fern, thrive in moist, humid environments where their spores c...'Gene chips' research in cotton could lead to superior variety
...ted into understanding of biological networks that regulate plant growth and production traits." The technology "provides a high-throughput tool for practical applications," Chen said. Those include a wide variety from medical diagnostics to plant breeding programs. The work was initially funded by ...A novel, safer strategy for regulating gene expression
...yme-based system can, in principle, be designed to regulate genes using any drug, or any chemical change in th...ent studies suggest that bacteria use ribozymes to regulate their own gene activity, by "sensing" and reacting to changing levels of natural compounds in their ...Joslin researchers clarify mechanisms for beta-cell formation
...ompensatory response. Dissecting the pathways that regulate the process of epithelial-to-mesenchymal transition will have therapeutic implications for both type 1 and type 2 diabetes. For example, modulating one or more proteins involved in this critical transition process may allow us to enhance the ability...Protein is key for digestive function of the pancreas
...as is the production of hormones like insulin that regulate blood sugar, the pancreas also produces digestive enzymes that are secreted into the gastrointestinal tract and break down carbohydrates, proteins, and fats present in the foods we eat. The harsh digestive enzymes secreted by pancreatic acinar cells...A probable cause for high blood pressure identified - shows links with diabetes
...ion within the cell) in the brain that is known to regulate blood pressure and release of insulin. Furthermore...tes another group of imidazol(in)e receptors which regulate insulin release. Among natural substances in the body, this molecule is one of the most potent relea......in a tightly constrained dose-dependent fashion to regulate MET, as both constitutively active and dominant negative forms of the protein disturb somitic epithelialization. Takahashi and colleagues further demonstrated that developing somites in the chicken are able to activate Rac1, suggesting a function for...Sugar-coated sea urchin eggs could have sweet implications for human fertility
...that sibling species have found different means to regulate their reproduction. "It helps to understand the process if you think of fertilization as sperm entering through several doors," she said. "In the past, we have focused on changes in the lock to the egg's protein door, and how sperm proteins are able...PNNL lands $10.3 million NIH biodefense contract to unlock proteomes of salmonella and pox
...tious Agents (NIAID) to identify the proteins that regulate the bacteria that cause salmonella poisoning and t...SU group has been able to knock out key genes that regulate the degree of pathogenic activity in the microbes. This capability will allow researchers to test pr...Cell's gatekeeper for ammonia revealed in unprecedented detail
...ently been found to be transmembrane channels that regulate the movement of ammonia and carbon dioxide in and out of the red blood cells, Stroud said. The red blood cells transport ammonia from tissues to the kidney, and transport carbon dioxide to the lungs. The gases are excreted from these organs. "Knowin...The search for a kinder, gentler chemotherapy
...tly they can hold onto them and how closely we can regulate the uptake and release," said Lyon....Screen siblings, parents of infants with severe heart abnormalities
... has three cusps or "flaps" that open and close to regulate the flow of blood. A bicuspid valve has only two. Individuals with this disorder are predisposed to heart valve infections and a narrowing of the valve later in life. Approximately 0.9 percent of people in the general population have bic...