NIH awards $18.2m to The Burnham Institute to develop Center on Proteolytic Pathways
...athways? Proteolysis, or how proteins break down, regulates the four fundamental aspects of cell behavior: division, death, differentiation, and motility. Understanding this process is critical to designing new therapies based on promoting or inhibiting cellular behaviors. A particular strength of the Cente...Researchers identify protein promoting vascular tumor growth
...that a certain form of berry extract significantly regulates MCP-1 function," said Sen, who served as a mentor to Gordillo on this research. The trick will be regulating MCP-1 levels safely, because the protein also is called to action to help wounds heal. Macrophages recruited in these cases make fre...Newly identified master gene key in baby's first breath
...me within hours of birth. "We showed that Foxa2 regulates a group of genes that stabilize surfactant production, which is required for the transition from the womb to breathing air and to protect the lungs from disease, bacterial infection and other disease and injury," Dr. Whitsett said. Foxa2 has an...Veterans with Gulf War syndrome have damage in specific, primitive portion of nervous system
... of the new study. The parasympathetic system regulates primitive, automatic bodily functions such as digestion and sleep, while the sympathetic nervous system controls the "fight or flight" instinct. "They're sort of the mirror image of each other the yin and the yang of the nervous system that co...Punching the timeclock of life
... to study aging because the molecular pathway that regulates its longevity is similar to that in other organisms, such as mice and possibly humans, Longo said. "Basically, it is the first demonstration, to our knowledge, that aging is programmed and altruistic," Longo said. "The organisms we have ...Marijuana use could cause tubal pregnancies
...r the first time how the CB1 receptor in the mouse regulates muscle contraction to move the embryo down the ovi...o years ago, the researchers found that anandamide regulates implantation of the mouse embryo in the wall of the uterus. At low concentrations, it synchronizes e...Molecule awakens and maintains neural connections
...esearchers have discovered a critical protein that regulates the growth and activation of neural connections in the brain. The protein functions in the developing brain, where it controls the sprouting of new connections and stimulates otherwise silent connections among immature neurons, and potentially in th...New dye directly reveals activated proteins in living cells
...es. Cdc42, a member of the Rho family of proteins, regulates multiple and sometimes opposite functions within the cell: movement, proliferation, cell death and shape. Injected into connective tissue cells, the dye "I-SO" displayed a bright green-colored fluorescence as Cdc42 activation and interaction with oth...Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
...ignal transducer and activator of transcription-3) regulates disease activity in experimental colitis and human IBD. Suppressor of cytokine signaling 3 (SOCS-3) and Src-homology tyrosine phosphatase 2 (SHP2) are negative regulators of Il-6 dependent STAT3 activation via the gp130 receptor. Growth hormone (GH) ...Heart gene yields insights into evolution, disease risk
...ot affect the structure of the protein itself, but regulates how much of the protein is produced in the cell. The variation, or polymorphism, is tiny, adding one genetic unit, or nucleotide, to the more than 1,600 that make up the regulatory region of the gene. However, the single alteration in the MMP3 protei...Molecular staples shape a cancer killer
...CL-2 domains" (SAHB). The BCL-2 family of proteins regulates apoptosis. When the researchers examined SAHB's properties, they found that it assumed a stable alpha-helical shape, bound to the right protein to trigger apoptosis, and resisted degradation by proteases. They also found that SAHB specifically trigg...Analysis of biological clock may lead to greater understanding of human disease
...chanism of genetic circuits by which the fruit fly regulates its circadian rhythm. The results are published in the August 30 Proceedings of the National Academies of Science. The mechanism controlling the biological clock generates a complicated dynamic behavior, oscillating back and forth and making it diffi...Synthesized molecules studied as weapon to stop cell division in cancer cells
...ational Meeting in Philadelphia August 22-26. Pin1 regulates the protein Cdc25, which initiates mitosis or cell division. Without Pin1, the cell enters programmed cell death -- which is good if it's a cancer cell. "It makes sense to inhibit the Pin1 enzyme," said Etzkorn. Protein shape determines biological ...Newly discovered protein may be key to muscular dystrophy
... Prozac, for example, modulates a transporter that regulates serotonin concentration. Besides carrying messages from nerve cells to muscle cells, acetylcholine triggers communication between neurons in the brain, and is involved directly or indirectly in many diseases, including Alzheimer's and diseases of per...JCI table of contents, 16 August, 2004
... Na retention, which suggests that CD-derived ET-1 regulates Na reabsorption through inhibition of tubule Na re....pdf The Fox in the Insulin Coop TITLE: Foxa2 regulates multiple pathways of insulin secretion AUTHOR CONTACT: Klaus H. Kaestner University of Pennsylvani...Rutgers-Newark biologist links presence of protein to spread of cancerous cells
...ormation while attempting to learn more about what regulates the changes of cells within healing wounds in epithelial (skin) cells. After introducing Rho into a culture of cells, some cells budded out of the tissue monolayer after which they would get moved lengthy distances away from the original source of th...Excess thyroid hormone harmful to fetus
...fect on the fetus of excess thyroid hormone, which regulates metabolism, because it was impossible to separate the effects on the fetus from the effects on the mother. This innovative study, however, provides a perfect example of how "errors of nature can help us understand normal hormone action," said Refetof...Coordinating power of circadian rhythms keeps estrus and pregnancy on track
... mutant mouse, which has a mutation in a gene that regulates the internal clock, researchers have shown that normal female reproductive function depends on an intact biological clock. It had previously been known that removal of the part of the brain responsible for circadian behavior resulted in abnor...LBP-1a gene mutation linked to disruption of normal fetal development
...is a protein that activates a gene and in this way regulates a specific process. The study found that mouse embryos lacking the LBP-1a gene were normal during the first 9 days of development, a time during which they survive by exchanging gases, nutrients and toxic breakdown products of food with their outsi...Bad news for pathogenic bacteria: Scientists find protein essential for bacterial survival
...tion into how the common organism Escherichia coli regulates gene expression has given scientists new ideas for...simovitch and her colleagues discovered that ppGpp regulates gene expression by controlling amino acid production in bacteria. A cell makes ppGpp when amino acid...