Florida Researchers Discover Gene For Fatal Childhood Disease
... Scientists also believe this gene plays a role in regulating thespread and development of cancers in general, and in protecting againstcertain autoimmune disorders. "This is significant for several reasons. Nobody knew what caused thisfatal disease," Kingsmore said. "Now we can design a diagnostic test. And...Harvard, Duke Researchers Discover 'Off-switch' Inside Human Cells
...inding also may offer a fundamentally new route to regulating cellactivity to treat heart disease, neurological disorders and other medicalproblems, say the researchers. In a report in the Sept. 12 Nature, the researchers reported discoveringa protein called RGS10 in human cells that seems to turn off, or dese...Two Long-sought Diabetes Gene Found
... turned on or off. Both were known to be active in regulating gene expression in the liver, kidney and intestine. "This surprising finding means we have to quit thinking of diabetes purely as a defect in glucose metabolism and starting thinking of it as possibly a defect in gene expression," said Bell. "That ma...Scientists Determine 3-D Crystal Structure Of Cancer-Causing Protein
...protein. The Src family plays an important role in regulating thebody's immune system and other cellular behavior. Src is found in nearly allcells of the body, but Hck primarily arises in cells related to the immunesystem, such as macrophages and B cells. In a related paper published in thisissue of Nature , a...Biosensor Is A Model For Widespread Testing Of Chemicals, Molecules
...in diagnosing particular disordersand in precisely regulating medications used during cancer chemotherapyor other complexes diseases. The study was funded by the Whitaker Foundation, which awarded Hellingaa three-year Whitaker Fellow grant. Hellinga is an assistant professor ofbiochemistry at the medical...New Gene May Intensify Breast Cancer Growth
... that this may be very important in breastbiology, regulating not just steroid growth response but possibly other growthresponse pathways. It could eventually be a target for therapeutics. It willcertainly be a target for significant additional biologic studies to understandits action," said Dr. Paul Meltzer, t...Jefferson Scientists Find Potential Deadly Effects Of Two Missing Cancer-Suppressor Genes
... the problem; both p53 and MSH2 are involved in regulating this cycle as well as controlling the genetic repair mechanism. Without these two genes, the result is "global, catastrophic cell death in developing females," according to Fishel. One mystery that remains is the precise role of the...... research because of theirwidespread importance in regulating complex locomotor, emotional andmotivational states." Grandy further explains that dopamine producing neurons are involved inmediating some of the positive reinforcing properties shared by drugs of abusesuch as alcohol, cocaine, methamphetamine and o...Presence Of Protein Extends Life; Potential Aging Mechanism Found
...pacity to moderate stress is a centralfunction to regulating that aging mechanism. In the study, Marc Tatar and colleagues from the University of Minnesotaexposed fly strains to short doses of nonlethal warmth, inducing expression ofa protein dubbed hsp70. Flies bred to contain extra copies of hsp70 genesres......ave familial background but the genetic factors regulating autoimmune response have so far remained unclea...gene have characteristics of factors capable of regulating the expression and/or function of other genes. Whether these other genes that are under control o...Regulator Of Fat Thermostat Found
... anunfinished jigsaw puzzle depicting the pathways regulating body weight."This one piece of the puzzle should lead to other areas worthy of examination,"he says. ### Note: For more information, refer to: Dagogo-Jack, Samuel, et. al., "RobustLeptin Secretory Responses to Dexamethasone in Obese Subjects," Journ...... eyes suggeststhat there is a common mechanism for regulating the development of new bloodvessels." Funding for the study was provided by the National Cancer Institute andNational Eye Institute of National Institutes of Health (which accounted forapproximately 50% of the funding) and Merck KGaA, Darmst......e time approaches for the cloning of children,laws regulating the clinical use of cloning should be based on the model ofexisting laws that protect the welfare of the child, such as adoption anddivorce laws. Editor's note: Dr. McGee can be reached by calling (215) 898-3453 or...Genetics May Explain Much Age-Related Hearing Loss
... loss may be lessened orprevented in the future by regulating an enzyme that neutralizes free-oxygenradicals, destructive molecules that can destroy sensory hair cells of the innerear, suggests preliminary research conducted in the University at Buffalo'sCenter for Hearing and Deafness. Using mice lack...Candidate Regulator Of The Temporal Component Of Neurotransmitter Release Identified
...tic transmission, only the molecular mechanisms regulating the amount of transmitter release are known in considerable detail. The observations reported in this paper are the first to directly implicate a defined molecule in regulation of the time course of transmitter release and thus are expect...UF Researchers Use Gene Therapy To Prevent Hypertension, Organ Damage
... a naturally occurring hormone that plays arole in regulating blood pressure. DNA is the spiral-shaped geneticmaterial contained in every living cell that transmits all hereditarycharacteristics. Scientists generally believe genetics may play a role inhypertension, although the exact cause of most cases is unkn...Growth Factors Shown To Increase Vitamin C In The Immune System
...o determine whethergrowth factors played a role in regulating this process. Previous researchhad shown that growth factors caused immune cells to take up more glucose-- a process that increases the metabolic fuel available for cellular function.One of those growth factors, called granulocyte-macrophage colony-s...EPA Should Redirect Some Research on Toxic Airborne Particles
...greatly increase the likelihood that moneyspent on regulating and controlling particulates will fully protect publichealth." EPA recently set stricter standards for particulate matter -- a broad class ofmaterials that originate from industrial manufacturing processes, forest fires,automobile exhaust, fossil fue...High Blood Pressure Caused By Salt Retention May Be Related To Oncogenes Implicated In Cancer
...her oncogene - src kinase, is also responsible for regulating theactions of sodium channels in some individuals. Learning how the kidney cells communicate and how they are regulated tomaintain the complex balance of salt and fluid will help researchers betterunderstand how kidney diseases begin and how...