Novel anti-cancer agent shows minimal side effects with preliminary evidence of tumor shrinkage
...t of mTOR, an enzyme that has an important role in regulating the synthesis of proteins that control cell division. Therefore, CCI-779 may stop the production of proteins essential for cancer cell proliferation and possibly survival of cancer cells. According to the researchers, ongoing studies are evaluating...Understanding key protein in Fragile X syndrome
...e, this protein may also play an important role in regulating the process. Identifying the proteins in the RNP complex is important, said Warren, because they may be involved in other types of mental retardation. "For most forms of mental retardation in humans, the genes have not been identified. Now that we're...DFG to set up 21 new collaborative research centres in 2000
...to conduct comparative studies of the signal paths regulating such differentiation processes in a variety of systems. Speaker: Prof. Dr. Dr. Walter Knchel, Abteilung Biochemie, tel.: 0731/502 3280/3281 Enzymes are proteins which control and catalyse biological processes. Many of these enzymes contain special m...Smell, taste may influence lifespan of the roundworm C. elegans
...-16,while somatic gonad signals extend lifespan by regulating the activity of the DAF-2 receptor. Regulation of lifespan by the reproductive system could be beneficial to the roundworm, Kenyonsays. If, for instance, an event, such as a mutation, were to occur in an individual animal to causesome of its germ c...Most highly endowed promotion prize for fourteen scientists and scholars
...ased on controlling the formation of the receptors regulating the uptake and storage of iron. Hentze was the first person to conduct a systematic study of metabolic regulation through control of so-called translation, the formation of proteins on the basis of genetic information. These pioneer studies are of gr...Mouse embryo hints at how mammalian body forms
...mation, they say, might be useful in the future in regulating the differentiation of embryonic stem cells. The investigators, including Cambridge University's Magdalena Zernicka-Goetz, PhD, and UC San Francisco's Roger Pedersen, PhD, discovered that the tiny mass of cells that forms in the first days follo...Cooperative action of two proteins causes damaged cells to "self-destruct"
...Abl, which subsequently'recruits' p73, another key regulating protein. The interplay between c-Abl and p73 leads to celldeath. "p73 was a surprise," admits Shaul. "Initially, we believed that c-Abl's most likely cell repairpartner would be p53, which until 1997 was perceived as the only tumor suppressor of its...UCSF researcher reports on protein therapy to reverse facial birth defects
...ion of vitamin A with various proteins involved in regulating face and brain development. They found that strategic doses of sonic hedgehog and another protein called FGF2, restored normal development of the chicks' faces and brains. "Obviously this is long way from treating a human fetus but it's a very impo...'Biomedical switch' regulates how cells stick together and communicates
Weizmann Institute scientists propose a model regulating cell adhesion -- central to embryonic development,...Cell Biology . The findings reveal a new parameter regulating cell attachment, namely, the physical properties of the immediate surroundings. Cell adhesion, wher...Light receptor may be key in how animals use Earth's magnetic field
... cryptochrome -- is known to play a prominent role regulating an animal's day-and-night rhythm. Now, UI scientists report in the February issue of the Biophysical Journal that chemical experiments and computational modeling indicate that cryptochrome may be the site of a neurochemical reaction that lets birds,......we do know that they're very important in terms of regulating the concentrations of different metals. They're also likely to be quite important in protecting tissues from various insults such as high oxygen levels." In other words, drinking alcohol may lead to systemic stress by producing oxygen radicals whic...Genetic mutations associated with epilepsy
...e that humans have 10 different genes dedicated to regulating the process---some control the passage of electrical signals in muscle cells, some in cardiac cells and some in neurons. These genes appear to be particularly significant, because they have been maintained throughout long periods of evolutionary dev...Mouse genome revealing which DNA sequences activate human genes
...oding DNA sequences that play an important role in regulating gene expression is the key to the success of this study, just as it has been a key to identifying DNA sequences that code for genes across different species. "If evolution conserved a sequence over the 70-90 million years since mice and humans diver...Protein found in yeast and humans appears to play a key role in regulating cell growth
...share a protein that appears to play a key role in regulating cell growth. Ronald Reeder, Ph.D., a member of the Hutchinson Center's Basic Sciences Division, heads the group that published the results of this work earlier this week in the Proceedings of the National Academy of Sciences (Early Edition No. 12). ...Life and death struggle: Proteins play against each other, bringing balance to immune system
...lance of the proteins that affect T cellsin effect regulating the immune response to an antigencould be used successfully with medical therapies. "You might be able to attack that balance by changing either IL-2 or IL-15," Dr. Marrack said.......on of nature's ingenuity, they also play a role in regulating the life span of a cell, because the tips of telomeres drop off chromosomes with each cycle of cell division.1 As the telomeres gradually shorten, the probability that they will signal the cell to stop dividing gradually increases. As a result, afte...Cincinnati Children's researchers uncover critical food allergy pathway
...trates a critical role for eotaxin specifically in regulating allergic responses in the gastrointestinal tract," says Dr. Rothenberg. "Since agents that block eotaxin and similar chemokines are being actively developed by a number of pharmaceutical companies, these studies provide impetus for rapidly applying t...... Molecular Biology and Biochemistry isolated a key regulating protein as it bound with other proteins to initiat... function improperly in people who have difficulty regulating their cholesterol levels," Osborne said. "We can use this information to design ways to make the re...Gene identified that may play role in psychological disorders
...hed June 14. The 5-HTT gene is responsible for regulating the chemical serotonin, which helps transmit messages in the brain. The people who showed a greater fear response during an experiment had a variation in the gene. This variation is linked to increasing the regulation of serotonin levels in the bra...New test for presence of nitric oxide could improve medical knowledge
...he popular drug Viagra controls penile erection by regulating nitric oxide. To understand the mechanism of nitric oxide's action in the body, medical researchers needed a sensitive means of detecting the molecule in vivo. An effective sensor system had to be sensitive only to nitric oxide, even in the p...