Tag: "regulation" at biology news

Gene changes linked to increased eye pressure may have implications for glaucoma therapy

...etter understand the role of these proteins in the regulation of pressure by the TM."Our goal is to determine if one of these proteins can be used to treat glaucoma," said Borrs. ...

Infants sighs may 'reset' breathing regulation mechanism as well as help lungs develop

...infants' lungs mature, sighs may "reset" breathing regulation mechanism BETHESDA, MD (August 12, 2004) A... observational study, the researchers measured the regulation of breathing, including breath-to-breath tidal volume, minimum exhaled oxygen and end-tidal carbon d...

Joslin Diabetes Center launches research section on developmental and stem cell biology

...matode (worm) Caenorhabditis elegans to study the regulation of genes important for the development of germ cells, which form the sperm and egg, and the early embryo. Germ cells represent an important stem cell model because they can give rise to an entire organism. According to Dr. Blackwell, C. elegans is ...

Jefferson scientists find gene expression pattern may predict behavior of leukemia

...c material that are thought to be important in the regulation of gene expression and in the development of cancer. MiRNAs can serve as stop signs for gene expression and protein synthesis, and are thought to play important roles in regulating gene expression in development. Reporting in both the online and the...

Coordinating power of circadian rhythms keeps estrus and pregnancy on track

...ich in female mammals requires precise but dynamic regulation of hormone levels. Many biological processes, including sleep and wakefulness as well as feeding and metabolism, have a 24-hour rhythmicity. The circadian rhythms that underlie these patterns are controlled in the brain by a molecular clock t...

'Smart gene therapy' protects against damage from heart attack

... of oxygen deprivation," Dzau said. "Such internal regulation is ideal for safe and effective gene therapy." The researchers injected the gene construct into the heart, liver and skeletal muscle of three rats in the laboratory. Five weeks later, they restricted blood flow to the animals' organs by clamping key ...

Wheelchairs biomechanics, prosthetic development

...e taken into account in the search for the optimal regulation of the user-to-chair interface. The Smart Wheelchair Component System provides mobility for people with severe disability , pg 429 This article describes the development and evaluation of a prototype of the Smart Wheelchair Component System (SWCS)...

Another key for the p53 door

... terms of possible therapies for the future, YY1's regulation of p53 at different levels means that we have new, different targeting options," says LICR's Dr. Johan Ericsson, the senior author of the study. "We know that we can use small molecules to prevent transcription factors from interacting with other pro...

Clusters of alterations on PIK3CA gene found in brain cancers

...aimed controlling brain cancer development through regulation of the errant gene, Yan said. Yan is an assistant professor of pathology, Duke University Medical Center. His colleagues who contributed to this work include Daniel Broderick, Chunhui Di, Timothy Parrett, Roger McLendon, and Darell Bigner, Duke Univ...

Firefly compound lights up 'protein dance' in living animals

...tested the new technique on two proteins linked to regulation of the cell life cycle. An anti-cancer drug is being developed to block the interaction of these proteins. "We can now monitor the effects of that drug in live animals using the luciferase technique," says Piwnica-Worms. "It's been an exciting develo...

Study reveals surprising 'remodeling' property of gene regulation process

...omosomal remodeling influences gene expression and regulation in human diseases such as cancer, Strahl said. "This is such a fundamental observation about the genome, but nobody had ever made it before," he added....

Researchers uncover surprising degree of large-scale variation in the human genome

...eptide-Y4 receptorthat is directly involved in the regulation of food intake and body weight. According to the study, a relationship between CNPs and susceptibility to health problems such as neurological disease, cancer, and obesity is an intriguing possibility. The study revealed considerable structural ...

Protein key to trafficking in nerve terminals

...ecycling. This has important implications for the regulation of vesicle retrieval mechanisms at the synapse, Bellen said. ...

Study yields insights into precancerous condition

...ad found that the diseases involved defects in the regulation of a protein called mTOR (mammalian target of rapamycin). The researchers, therefore, decided to look for a link between LKB1 and mTOR. As predicted, their study found that mouse cells lacking LKB1 and cells from PJS mouse polyps showed the activatio...

NRH1 and Wnt signaling come together in convergent extension

...posterior axis. A number of genes involved in the regulation of convergent extension have been identified in am...t the product of the gene NRH1 is essential to the regulation of CE movements in the frog. While performing a screen of genes expressed in the posterior neuroecto...

Reading hexametric rhyme supports cardiac synchronization, especially after a heart attack

...atterns found in poetry readings on cardiovascular regulation have been investigated extensively in recent years. Poetry recitation has been known to cause a frequency adjustment of breathing oscillations with endogenous blood pressure fluctuations (Mayer waves) and even cerebral blood flow oscillations during ...

Significant strides in small regulatory RNA research in plants

...specific roles in plant development, including the regulation of flowering time and floral organ identity, and l...suggests that some miRNAs might be associated with regulation of gene expression in response to stress. Together, these two reports open new avenues of...

Genetic model for devastating form of paraplegia suggests new treatments

...gest that HSP is caused primarily through impaired regulation of the nerve cell cytoskeleton," says Broadie, professor of biological sciences and pharmacology and an investigator at the Kennedy Center for Research on Human Development. "Spastin, as well as other HSP-linked genes, appears to mediate this common ...

New drug shows promise against Gleevec resistance in mice

...at The Rockefeller University, who had studied the regulation of Abl kinases for many years, made the seminal discovery that Gleevec, or STI-571, worked by binding to Abl when the enzyme was in its "off" position. If Abl was in the "on" position, the drug would not work. In the arcane worlds of cellular s...

European researchers tackle mitosis

...this European project to determine the biochemical regulation of mitotic genes, and to test them as tools for cancer diagnosis. All data produced through MitoCheck will be readily available to the scientific community and the public through databases at the DKFZ, and at The Wellcome Trust Sanger Institute, ano...

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