Scientists discover key step in the development of nerve cells controlling autonomic functions
...where he discovered novel proteins involved in the regulation of mammalian neural development. Dr. Stifani's research aims to clarify the events that underlie neuronal birth and survival in both the developing and adult nervous system. His studies have led to the characterization of crucial mechanisms controll...Study reveals evolution on the (butterfly) wing
...development, the researchers are revealing how the regulation of two key genes has evolved in association with s...s. These analyses implicated Notch and Distal-less regulation in the very early stages of color pattern development. Also importantly, the moth species showed no ...Altered expression of key developmental genes underlies evolution of butterfly wing patterns
...the University of Wisconsin, Madison, show how the regulation of developmental patterning genes changed during the evolution of line and eyespot color patterns. Comparing eight species of moths and butterflies, the researchers found that signature alterations in the timing of expression of two well-studied gene...A genetic model for hereditary spastic paraplegia (HSP) disease
...t, in many cases, HSP may result from the improper regulation of microtubules, which make up a large part of a nerve cell's scaffolding. This could explain why the specific nerve cells that are preferentially affected in HSP those that send signals from the brain's cerebral cortex to the motor neurons that ini...XsalF comes to the fore in brain regionalization
...tinct, aspects of regions-specific transcriptional regulation -- the switching on of fore- and midbrain-specific genes, and the suppression of posterior genes. The Sasai lab now plans to conduct further studies to develop a detailed model for understanding both the direct and mediated effects of XsalF in neural...Other highlights in the July 7 JNCI
...With Increased Risk of Esophageal Cancer Abnormal regulation of apoptosis, or programmed cell death, can lead to many diseases, including cancer. In a new study, Dongxin Lin, M.D., of the Chinese Academy of Medical Sciences in Beijing, and colleagues find that genetic polymorphisms in two genes that play a rol...JCI table of contents, 1 July 2004
...diated angiotensin II generation in blood pressure regulation AUTHOR CONTACT: Ahsan Husain University of Alabama...t tissues, skeletal muscle, liver, and fat, in its regulation of glucose metabolism. Recent evidence suggests that there is cross-talk between these tissues coord...Severe depression associated with greater number of nerve cells in thalamus region of brain
...he part of the brain that is involved in emotional regulation is physically different." Four groups were represented in the study: subjects with major depression, with bipolar disorder and with schizophrenia, as well as a comparison group with no history of mental illness. Major depression is characterized by a...Gerontology researchers urge scrutiny of anti-aging treatments
... there are many barriers to effective governmental regulation of anti-aging interventions, state authors Maxwell J. Mehlman, JD, Robert H. Binstock, PhD, Eric T. Juengst, PhD, Roselle S. Ponsaran, MA, and Peter J. Whitehouse, MD, PhD. Support for the preparation of the article was provided by the National Insti...... active Pak then induces more Rac activation. Such regulation may be important for maintaining continuous cell movement....Donaghue Women's Health Investigator Program awards grants to three at Yale
...rtex. This receptor appears to be involved in the regulation of mood and the actions of antidepressants. Results from this work will enhance understanding of the neurobiology of peri- and postmenopausal depression and may have profound effects on the treatment of depression during this stage in women's lives....USC researcher named General Motors Cancer Research Scholar
...chool is concentrated on so-called epigenetic gene regulation the heritable on and off switches of genes that are associated with chemical modifications to the DNA and proteins in the nucleus that will ultimately make a difference in the understanding and treatment of cancer. A native of Phoenix, Ariz., Rice ...Scientists discover genetic marker responsible for two-fold increase in risk of rheumatoid arthritis
... for this enzyme, the team found that the negative regulation by this enzyme appears to be inefficient, so that T cells and other immune cells are hyperresponsive, causing increased inflammation and tissue damage. "This is not an abnormal gene," said Dr. Gregersen. "It is present in a substantial frac...Joslin researchers identify key molecule in Type 1 diabetes progression
...ing the molecular and cellular basis of the immune regulation in the lesion might some day lead to the development of therapies that favor regulatory T-cells and respectful insulitis, preventing the development of full-blown diabetes even after insulitis has developed," Herman explains. Mathis and Benoist ho...Evidence for fat hormone target in brain
...eurons in the brain -- a prime link in the brain's regulation of the body's energy balance. Leptin is known to be produced by the body's fat tissues and to signal brain cells to reduce appetite and food intake and increase energy expenditures. Although researchers had produced indirect evidence that leptin affe...Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
...proach will give us important clues about the gene regulation in a number of cells in normal and cancer tissue," he says. "It opens new avenues for treatment because these miRNA genes are so small, they can get into cells and be used as drugs. Characterizing their targets might help in understanding cancer phen...Energy conservation targets hit by notions of 'comfort'
...y in that direction. Some thought that only strong regulation a 'big stick' or a ban on domestic units would halt the trend. Others suggested that changes throughout the design process would be needed as at present there were no 'brownie points' for environmental innovation or for initiating debate about the ...UK small firms pay lip service to green issues
...The inescapable conclusion from the study was that regulation may be the only way to truly effect change within the SME sector. 'Legislative sanctions are clearly one way to be certain that the environment becomes a top business priority for small firm owners,' says Revell. ' Regulation makes the environmental...Scientists discover new role for tiny RNA in plant development
...ressed an miR164 target gene that was resistant to regulation by miR164, allowing the researchers to observe the...of leaves and flowers in both mutants. When miR164 regulation of a target gene was absent, plants produced the wrong number of organs. For example, flowers tended...New national research effort needed to secure clean, adequate water supply in coming decades
... that has been complicated by recent drought. And regulation of water levels and flows in the Klamath and Missouri rivers have sparked considerable debate as well. "Decision-makers at all levels of government are going to have to make difficult choices in the coming decades about how to allot limited water su...