Duke Researchers Discover Central Role Of Nitric Oxide In Hemoglobin Action
...nitric oxide, combined with hemoglobin, is a major regulator of gas exchange,as well as blood pressure, in the circulatory system. The finding appearsto have solved the long-standing mystery of how blood carries oxygen tobody tissues and extracts waste carbon dioxide while keeping vessels openand blood pressur...Nitric Oxide May Hold Key To First Treatment For Deadly Form Of Malaria, Duke Scientists Report
...n NO compound, combined with hemoglobin, is amajor regulator of gas exchange, as well as blood pressure, in the circulatorysystem. That work was published March 21 in the British journal Nature. The current discovery was made when the researchers were studying why somebacteria escape attack by immune ...Nitric Oxide Found To Control Cells By Turning On Genes; Suggests New Role In Health And Disease
...n NO compound, combined with hemoglobin, is amajor regulator of gas exchange, as well as blood pressure, in the circulatorysystem. That work was published March 21 in the British journal Nature. The current discovery was made when the researchers were studying why somebacteria escape attack by immune ...Scientists Bridge Gap In Cell Communication
...wth. "We've shown that the MAD protein is a direct regulator of target gene transcription in response to a (specific) signal." The mapping of the communication pathways between cells is a fundamental quest in modern biology. Identifying the messengers -- a large family of proteins that carry genetic ...Research Finds Alligator Problems Also Evident In Less Polluted Lakes
...environmental toxicants on the thyroid, a critical regulator of growth in animals. Biology Professor Drew Crain, a former student of Guillette now teaching at the University of Mississippi, said the study shows that problems found in Lake Apopka alligators are confined neither to that lake nor to one system ...Prostate Cancer Switch May Yield Map Of Cancer Machinery, Targets For Drugs
...rogresses. "As we get closer to the master regulator for this system, we believeit's likely we will find many more targets for anti-cancer drugs to selectivelykill these aggressive tumors earlier," he said. "And, we believe we will findmarkers that would allow physicians to tell whether a particular ma...Cystic Fibrosis Gene Protects Against Typhoid Fever
... known as cystic fibrosistransmembrane conductance regulator (CFTR). In these children, abnormal CFTRblocks the movement of chloride ions and water in the lungs, gastrointestinal tract, and other tissues and causes them to secretelarge amounts of mucus. As mucus accumulates in their lungs, these childrenbeco...Naked DNA Rejuvenates Rheumatoid Rodents
... growth factor-beta(TGF-), a protein that is a key regulator of inflammation-the body's responseto infection or tissue damage. Drs. Xaio-yu Song and Sharon Wahl from the National Institute of Dental Research(NIDR), and MiLi Gu from the Food and Drug Administration (FDA) tested the TGF-plasmid in a rat model fo...Virginia Tech Biologists' Discoveries Could Help Target Cancer Treatment
...acts not only in cell proliferation, but also is a regulator of celldifferentiation. Because most anticancer drugs inhibit cell division byinterfering with either DNA synthesis or repair, RPA is a potential target fortherapeutic intervention. "Using deletion analysis and site-directed mutagenesis we h...Scientists Learn How Cells Limit Their Stress
...cule they callHSBP-1, the first known "off-switch" regulator of chaperone production. HSBP-1binds both to the chaperones and to heat shock factor and prevents the factorfrom activating genes to produce more chaperones. "This is the first time we've seen a new regulatory molecule other thanchaperones that contr...Molecular Marker May Identify Bladder Cancer Patients Most Likely To Recur
...disease. In addition, p53 is known to be a primary regulator of p21, sincegenetic changes in p53 may lead to loss of p21 expression and function. This inturn leads to unregulated cell growth, and is thought to contribute to theaggressive behavior of some tumors. Importantly, in this study, researchers found th......ghausen neurofibromatosis’. This unit is a regulator of another protein involved in the pathogenesis of...le of neurofibromin. It functions as a negative regulator of Ras, another protein that is intimately involved in the regulation of cell growth and diffe......revealed that the cyclops gene product is a potent regulator of cell fates in embryonic tissues. Cyclops, the researchers argue, is crucial during the gastrulation stage for mediating an early signaling pathway for ventral brain and floor plate differentiation. Rather than respond to signals arising solely fr...Scientists Find New Clues About Fatal Childhood Disease, Ataxia Telangiectasia
... disease ataxia telangiectasia* (A-T)acts as a key regulator of cell division after DNA damage. The finding helpsresearchers understand how cells in A-T patients form tumors and may lead to newunderstanding of other neurological and immune disorders. The new research shows that the protein, called ATM...Leptin Regulates Hunger During Energy Deficit In Women
...ings support the idea that leptin is a physiologic regulator of hunger during energy deficits in humans; the role of leptin in the long-term regulation of food intake warrants further study....New Discovery Is Potential Key To Obesity Treatment
... called Agrp, that theysuspectedto be an important regulator of the melanocortin pathway. Now they have shownthat the product of that gene, a protein they call AGRP, blocks the binding ofalpha-MSH. The researchers believe the likely result is increased foodconsumption. While this might be desirable sometime...UI Researchers Find Potential Gene Therapy For Cystic Fibrosis
... protein, known as the CFtransmembrane conductance regulator (CFTR), makes the channel. The gene thatcodes for the CFTR protein is mutated in people with CF.McCray said the UI research project was designed to complement other CFtreatments under laboratory investigation, including another UI study. Thosemethods...Fly Tumor Points Way To New Understanding Of Cancer Development
...use these LATS molecules are a new typeof negative regulator for the enzymes that drive the cell cycle," said Xu. Thus, he said, the finding hints that further explorations into themolecular signaling machinery involving LATS1 may yield insights intolittle-understood cancers and perhaps lead to new cancer the...... promote metastasis. "RRM1 may not be the direct regulator of metastatic spread," Bepler said. "Itmay be a modulator in a cascade of events that result in metastasis." As a result of these unanswered questions, Bepler's research team is continuingto study both the LOH11A region as well as the rest of the ar...NYU And Rockefeller Scientists Design Molecules That Stymie A Notorious Bug
...peptide produced by one strain inhibited theglobal regulator of a second strain, meaning that the first strain couldpotential block the ability of the second strain to cause inhibition. In the new study, Drs. Novick and Muir describe the chemical structure ofthese peptides and custom design molecules...