Tag: "regulator" at biology news

NYU announces establishment of a center for comparative functional genomics

... express a protein closely related to an important regulator of neural activity in the brains of vertebrate animals, including humans. The existence of this plant protein offersthe opportunity of isolating and testing new drugs that could aid in the treatment of neurological diseases, as well as developing ne...

Little-known substance regulates inflammatory response

...spread than anticipated and that it was a critical regulator of inflammation in multiple tissues. "We found that rapid expression of A20," said Ma, "was absolutely essential for down-regulating the inflammatory response and averting the damage unrestrained inflammation can cause in multiple tissues." Within ...

Scientists spot way around cystic fibrosis cells' poor performance, way to improve drug testing

...d." Exploiting what appears to be a newly found regulator of cystic fibrosis chemistry, scientists at Johns Hopkins report they have been able to experimentally improve the function of the cell molecule most affected by this common inherited disorder. Writing in the October edition of the journal Cell, the ...

Researchers identify molecule that senses osmotic pressure in vertebrates

...anufacture antidiuretic hormone (ADH), the primary regulator of body water. Liedtke found VR-OAC expressed in neurons in brain structures called the circumventricular organs. Most of the brain is protected by the blood-brain barrier, a gateway that allows only certain substances to pass into the brain. The c...

Smooth regulation of lipid metabolism

...ant receptor for cholesterol derivatives is a gene regulator known as LXRa. The first of these two articles identifies SREBP-1c, a novel gene target of LXRa. The SREBP-1c protein is also a gene regulator; it in turn controls the expression of lipogenic enzymes. It was previously known that SREBP-1c played a ro...

Fighting Fungi

... nitrogen-rich conditions is an essential UPR gene regulator produced, and therefore the UPR active. Thus, the UPR mediates the environmental regulation of pathogenicity. The discovery that the UPR represses filament formation lends new insight into the developmental design of anti-fungal therapies. Drugs whic...

Cytoplasmic FRAP must enter and exit nucleus to perform

...lar functions, which further underscores a central regulator role of FRAP," Chen said. The Harvard finding involving yeast, in research led by Elaine A. Elion and published in August 1999, focused on the protein Ste5, a cytoplasmic protein that appears to act much like FRAP does in mammalian cells. Researcher...

Too much of a good thing

...ation. The effectiveness of RA as a developmental regulator depends on the precise control of its distribution. In order to elucidate the developmental role of CPY26, Dr. Hamada, Dr. Petkovich and colleagues removed the gene Cpy26 from a srain of mice. Cpy26 mutant mouse embryos exhibited elevated levels of ...

Where does my heart beat now?

...ercola report on their identification of a crucial regulator of vertebrate heart formation. The heart is formed from cells originating from the mesoderm, one of the three basic embryonic tissue types. Since the 1960's it has been known that the adjacent endoderm secretes factors that promote heart formation...

A worm is more like a human than previously thought

...e vastly different creatures. "We found that a key regulator of early development is the same in worms and vert...is Maduro and Rothman found that there is a common regulator gene that controls the formation of many of the internal organs in both nematodes and vertebrates. T...

Merlin tells when to grow and when to stop

...vious studies have identified merlin as a negative regulator of cell growth, this paper is the first documentation of merlins specific role in the contact inhibition of growth. Under high cell density conditions, the extracellular portion of the cell membrane-spanning protein, CD44, binds to a specific compone...

New protein is essential for lung development

...-deficient mice identify this gene as an essential regulator of lung mesenchyme. Development, June 1, 2001. http://www.biologists.com/Development...

Study reveals molecular key to tumor suppressor activity

...other implications. "Protein transport is a major regulator of cellular function. This represents one of the first examples where a nuclear exporting signal can be regulated by phosphorylation," he said. "In half of all tumor cells p53 is not working, sometimes because a kinase gene responsible for p53 phosp...

Study uncovers structure of key molecule responsible for clearing drugs from the body

...umans. The molecule, known as PXR, is the master regulator of a protein called cytochrome P450-3A, or CYP3A, ...tant to human health. Interactions involving the regulator molecule, scientifically known as a nuclear receptor, have led to so-called "St. John's wort babies"...

Gene that directs fate of many embryonic stem cells identified

...riments, demonstrate that this gene is the central regulator of embryonic stem cell development into endoderm," Stainier said. "This gene appears to be a potent candidate to improve the efficiency of directing embryonic stem cells to produce medically needed cells and tissues." "Our next step is to demonstrate...

All RBs are not alike: insight into RB in the plant cell cycle

...action. In mammalian cells, RB is a key checkpoint regulator of cell cycle progression. Under certain condition...in cell division regulation, but not as a negative regulator of S phase transition. Dr. Goodenough and colleagues found that the RB homolog functions in algae as...

New 'mighty mice' research brings muscle growth closer to reality

...etically engineering animals with a missing growth regulator called myostatin have now created a second group of mice whose genetic makeup shows it's possible to get the same effect by blocking the gene for myostatin, rather than entirely knocking it out. Reporting in the July 16 issue of the Proceedings of t...

Researchers at UT Southwestern discover link between gene in rare disorder and growth factor

...d vascular endothelial growth factor (VEGF), a key regulator of blood vessels. The discovery will help researchers better understand Peutz-Jeghers syndrome and the development of the cardiovascular system. Their findings appear in the Aug. 17 issue of Science. "We found that Lkb1 is very important for regulat...

New protein may play role in preventing malignant change in cells

... E levels become very high, he said. It truly is a regulator of cyclin E. In addition, the researchers found that the laboratory breast cancer-derived cell cultures that made the most cyclin E failed to make Fbw7 at all. This (the gene that is the code for production of Fbw7) is very probably a tumor suppress...

Masking genetic mutations

...ch Institute in Tokyo, Japan have identified a key regulator of the expression of genetic mutations and, in the process, have developed an intriguing therapeutic approach to combat prevalent genetic disorders. We dont realize the full extent of our genetic mutations. Nonsense-mediated mRNA degradation (NMD), o...

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