Brain Protein "Rescues" Neurons From Atrophy
...d. This specificity showed that NT-4 was part of a regulatory system, and not a general growth factor. Neurobiologists believe that the brain wires itself as a result of experience -- permanently strengthening neuronal connections that are more heavily used. A central mystery, however, has been how such heavier...Duke Researchers Discover Central Role Of Nitric Oxide In Hemoglobin Action
... In addition, the research shows that NO has a regulatory "allosteric"function that has not been described before, Stamler said. Allosteric regulationis when one molecule causes a protein to change its shape and, thereby,its function. Hemoglobin is "a classic allosteric protein" becauseits function depends ...Tumor Suppressor Gene Located In Liver Cancer Cells
...IGF2r receptor protein has at least three distinct regulatory -- or "traffic cop" -- roles within a cell, said J...ng this gene. "Instead of carrying out its normal regulatory functions, this shortened protein leaves the cell. Once outside, it can no longer regulate cell gro...Nitric Oxide May Hold Key To First Treatment For Deadly Form Of Malaria, Duke Scientists Report
...an NO group, attached to a thiol withina cell, has regulatory function," Stamler said. "There has beengrowing evidence that NO does its work in the body by signaling genes, butno one has found proof before this." Both oxygen and NO are vital to life processes, but too much of eithercan damage cells. T...Nitric Oxide Found To Control Cells By Turning On Genes; Suggests New Role In Health And Disease
...an NO group, attached to a thiol withina cell, has regulatory function," Stamler said. "There has beengrowing evidence that NO does its work in the body by signaling genes, butno one has found proof before this." Both oxygen and NO are vital to life processes, but too much of eithercan damage cells. T...Two Long-sought Diabetes Gene Found
...DY3). HNF-1-alpha and HNF-4-alpha are members of a regulatory pathway first identified in cells of the liver but present in other cells including those of the kidney and intestine. This pathway was not considered to be important in the insulin-secreting cells of the pancreas and thus was overlooked in the searc...New Study Shows Steps Leading To Colon Cancer
...veals for the first time the precise role of a key regulatory protein found in both insects and ourselves," said Dr. Mark Peifer, assistant professor of biology at the University of North Carolina at Chapel Hill. "We have found that this protein, called 'armadillo' in insects and 'beta-catenin' in humans, goes ......re simply too high." Moreover, by imposing regulatory costs of $60,000 to $1 million perregistration, th...ny other crop." However, the economic and regulatory burdens of EPA's policy willgreatly discourage the use of genetic alternatives to develop pest-resis...Common Food Dye Can Cause Severe Allergic Reactions
...rant, widespread use today, manufacturing process, regulatory classification and chemical makeup. He also discovered that on rare occasions it had been suspected---though not confirmed---as the cause of anaphylactic shock and asthma in workers who processed the extract. Physicians often confirm the result...New Molecular Switch Is The Key That Unlocks DNA Repair
... says. [Now we know that] “they serve as a regulatory molecular switch. Because we understand the true ...ese cancers.” Fishel believes that similar regulatory switches may be involved in these other cancers. "Now that we understand one of these switches...Researchers Discover New Genetic Risk For Alzheimer's Disease
... alter your risk, andwe found those changes in the regulatory part of the gene, which controls howmuch APOE protein our cells produce," said Alison M. Goate, Ph.D., associateprofessor of genetics in psychiatry and a lead author of the study. Goate's team at Washington University collaborated with Span...Peutz-Jeghers Disease Gene Identified: Enzyme Loss Causes Polyps And Cancer
...in kinase family. Protein kinases are cytosolic regulatory enzymes which modify the functional properties of certain cytosolic proteins (substrates) by adding phosphate groups to the side chains of serine, threonine or tyrosine residues. Kinases have highly diverse functions and are implicated in...Virginia Tech Engineers Help Mother Nature Clean Up
...ter of the soil, and other local features." For regulatory bodies such as the EnvironmentalProtection Agency (EPA) to accept a proposal from a company thatplans to use phytoremediation, these questions need to be answered.N&W's commitment of $400,000 in funding to identify solutionsrepresents a strong co...Good Ergonomics Is Good Economics
...entire research program was $2 million and for the regulatory program, $3 million (Transportation Research Board, National Research Council, 1989). A $5 million dollar investment for a projected $910 million annual return: not a bad ergonomics investment by the federal government! Poultry de-boning knife. A c...National Toxicology Program Meets On Transgenic Animals
...pecific tumor models? Are the scientific needs of regulatory agencies being adequately addressed? Dr. Joseph C...DA, and Dr. Vicki Dellarco, EPA, will speak on the regulatory needs. For advance materials on the transgenic session, contact Dr. Larry G. Hart, NTP Executive ...Transposable Elements May Have Had A Major Role In The Evolution Of Higher Organisms
...o-opted bythe host plant or animal cell to serve a regulatory function. McDonald said it is increasingly clear that organisms need transposonsand that their apparent continual back-door assaults on normal genes may, intruth, be more like a vast, sophisticated chess game on an enormously complexboard. ...Molecular Mechanochemistry: An Emerging Discipline At The Nexus Of Biology And Physics
...line ofinvestigation is helping us to discover key regulatory molecules important forpreventive therapy in such diseases as atherosclerosis and hypertension," saysPeter F. Davies, PhD, director of Penn's newly formed Institute for Medicine andEngineering, an organizational blending of medical and engineering fa...Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation
...external conditions. Moreover, it has important regulatory roles in numerous biological processes such as cell cycle, apoptosis or the immune response. A research team at the Max Planck Institute of Biochemistry in Martinsried/Germany, headed by Wolfgang Baumeister, since several years one of the...Developing Florida's Marine Food Fish Industry
...d regulations. Food fish production,marketing and regulatory panels will prioritize species for marine food fishaquaculture in Florida. Entrepreneurial and research opportunities will beidentified. Registration includes a workshop proceedings. Registration fees are as follows: Other fees: ...Butterfly Wings, Beetle Horns Teach Biologists Basic Lesson In Development's Laws
...e fact there must bethese larger-scale biochemical regulatory mechanisms that manage size regulationand proportional regulation among body parts. "We hope that this paper will demonstrate that these are approachablesystems, that the questions are still out there and are interesting andimportant." ...