OHSU-VAMC study sheds light on estrogen's benefit for MS
...und there was a marked reduction in the rate of MS relapse during pregnancy, especially in the third trimester. Three years later, Offner and a team of OHSU and Portland VA Medical Center neurologists published a study showing treatment with low doses of estrogen protects mice from developing EAE, but the me...Outcome for acute lymphoblastic leukemia linked to gene expression patterns
...relapse. The ability of these genes to forecast relapse was then validated in a completely independent group of 98 children who were treated with these same drugs, but on a different treatment protocol at St. Jude. "The gene expression patterns linked to drug resistance were particularly important s...Acamprosate: potential medication for treating alcoholism
...medication used in Europe and elsewhere to prevent relapse in alcoholics. New findings, in conjunction with p...medication used in Europe and elsewhere to prevent relapse in alcoholics, and currently under review for use by the U.S. Food and Drug Administration. The stu...OHSU scientists find gene influencing drug withdrawal
...isms, and contribution to continued drug abuse and relapse are uncovered, new pharmaceutical therapies could be identified, Buck said. "For those people who are susceptible to drug withdrawal and are being treated for drug abuse, therapies focused on this gene and/or proteins it interacts with could make sen...Abnormal chromosomes forecast leukemia relapse
...tly shorter survival. They were twice as likely to relapse and die. Based on their findings, the researchers concluded that converting from abnormal chromosomes to normal chromosomes at remission is an import predictor of long-term outcome in AML, and supports the use of cytogenetics testing at remission. "...Breast cancer patients failed by treatment with taxol and taxotere respond to abraxane
...ol or Taxotere in the metastatic setting, or had a relapse within 12 months of adjuvant taxane therapy. The patient population studied had a poor prognosis with 91 percent having visceral (lung and liver) disease, 65 percent with more than three metastatic sites and 88 percent demonstrating ongoing tumor gr...APP reports Abraxane(TM) is active in breast cancer patients who failed taxol or taxotere
...OL or Taxotere in the metastatic setting, or had a relapse within 12 months of adjuvant taxane therapy. The patients enrolled in this study had a very poor prognosis, with 91% having visceral (lung and liver) disease, 65% with more than three metastatic sites, and 88% demonstrating ongoing tumor growth whil...Other highlights in the May 19 JNCI
...tients and is associated with an increased risk of relapse and death in patients with early-stage breast cancer. In earlier clinical trials, adding trastuzumab, which blocks the effects of HER2, to standard chemotherapy increased both the response rate of patients and survival, but an unacceptable number of ...Drug combo effective in advanced breast cancer
...in a poor prognosis. Patients with this alteration relapse more quickly and die more often than those who do not have it. Developed based on 12 years of laboratory and clinical research by Slamon and other UCLA researchers, Herceptin targets the HER2/neu alteration and blocks its effect. It was among the fir...Genetic signature may predict recurrence in colon cancer patients
...only have local disease, however, the incidence of relapse indicates existence of undetected disseminated dis...ion. Thirty-one of these patients developed tumor relapse in less than three years, while 43 patients remained disease-free for more than three years after su...Genetic screening study at Stanford ID's most aggressive adult leukemia strains
...to treat the cancer because aggressive forms often relapse after chemotherapy. Treatments such as stem cell transplants, on the other hand, are considered too risky for patients with less aggressive forms of the disease. In the study, Pollack's colleagues in Germany collected tumor samples from 116 adults wi...Support needed for elderly breast cancer patients and for independent academic research
...cancer patients should not be limited to detecting relapse but should include psychological support and the management of treatment side effects. Care after breast cancer should be planned by a multidisciplinary clinic after discussion with the patient....First large-scale trial of genetically personalised treatment for breast cancer to start soon
... will be possible to spare patients at low risk of relapse from over-treatment with chemotherapy", said Dr. Piccart. "This will result in reduced side-effects and will also save health services from unnecessary costs." "Our trial will be the first to test this theory in practice on a large scale", said Dr....New diagnostic tool brings effective treatment closer to patients
...s. The use of microarrays will be able to predict relapse or metastatic disease in patients treated by the current standard of care, therefore sparing selected patients from chemotherapy or closer monitoring and/or dose intensification in patients at high risk. The information provided by this new tool sho...Astrazeneca announces EU marketing approval for Faslodex(TM)
... advanced or metastatic breast cancer, for disease relapse or progression on or after therapy with an anti-oestrogen such as tamoxifen. 'Faslodex' has been launched in the USA since May 2002, and more recently in Brazil in July 2003. Breast cancer affects 1 in 9 women at some point in their lives and althou...Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters
... practical treatments for alcoholism, particularly relapse prevention. The center will also aim to bring thes...gic activity changes are probably a major cause of relapse to alcoholism in individuals undergoing treatment. Previous studies have also shown that alc...Anti-interferon beta antibodies in MS care: A consensus
...cal School, "Patients who develop NAbs show higher relapse rates, an increased number of enlarging brain lesions, and new lesion formation compared with NAb-negative patients." Long-Term MS Therapy and Neutralizing Antibodies The rise of biologics (protein-based medications, which are similar to regulatory...Scripps Research receives $3 million anonymous donation
...ed nalmefene, which proved effective at preventing relapse to heavy drinking in alcohol-dependent individuals...o received nalmefene were 2.4 times less likely to relapse to heavy drinking than those who received a placebo. Mason was also the principal researcher on a c...Newly identified genes may help predict outcome in childhood leukemia
...e long-term remission. Yet, 25 percent of patients relapse with resistant disease. Additionally, 25 percent ...difficult to know which patients will experience a relapse in the disease when they become resistant to the therapy. Hopefully the identification of new genes...New drug target and biomarker for advanced childhood cancer discovered
...after surgery and chemotherapy because of the high relapse rate," Dr. Nuchtern said. "This gene may make possible a sensitive means of detecting those." Dr. Yang discovered the gene, a novel structure, during a screening using microarray technology. He subsequently discovered the gene was only expressed in n...