New sequence involved in DNA replication timing may aid in cancer detection
...S phase. The researchers confirmed this finding by removing the LCSs from a late-replicating origin to convert it to an early-replicating origin. "Interestingly," noted Huberman, "in many cancer cells, the normal order of DNA replication is altered: regions that should replicate late sometimes replicate early...ORNL's Delmau joins Technology Review's list of top young innovators
...ental in the development of a selected process for removing radioactive cesium from nuclear waste material. She has more than 40 open-literature publications, including 15 journal articles and a book chapter. Overall, she has three patents. This year's TR 100 group was selected from a field of nearly 650 ...Washington University in St. Louis leads group studying aging process
... molecular biology genomics. The FIBR program is removing the limits biologists have found increasingly frustrating in recent years when seeking funding and finding they can't continue research because they've hit a technological barrier they can't cross. Pakrasi and his collaborators first obtained a NSF $...Reducing allergens in the home helps inner-city children with asthma
...gen-impermeable covers; repairing water leaks; and removing carpet from the bedroom, if possible. Families were also given HEPA (high efficiency particulate air) filters. Cockroach extermination visits were provided in homes where children were sensitive to that allergen. The suggestions were typically well-r...Study suggests cell-cycle triggers might be cancer drug targets
...Farber Cancer Institute scientists have found that removing three key proteins believed essential to cell division and growth had little impact on normal tissue development of a mouse embryo. These same proteins, when overly active, have been linked to cancer cell proliferation. With one significant exception...When is a mouse like a test tube?
...ts try to control the environment of a reaction by removing as many other chemicals as possible. "Synthetic chemists try to eliminate all interfering chemical groups, which can be difficult in a biological system," Bertozzi said. "We design functional groups to be specific, so they don't react with the enviro...Muscling their way into the food chain: Zebra mussels alter fish populations in the Hudson River
...lter all of the water in the river every 1-4 days, removing the microscopic plants and animals that make up their diet. This can be problematic for fish species that rely on the same food resources. "Zebra mussels have significantly reduced populations of zooplankton and other animals that are a dietary stapl...Early clinical treatment can halt progression of Alzheimer's disease, UCI researchers find
...ade hypothesis. We've demonstrated in the lab that removing plaques from the brain can indeed lead to a total ...hen the amyloid therapy was no longer effective at removing the tangle pathology. "The tangle pathology evolves through various stages," LaFerla explained. "It...Computer imaging of Archeopteryx skull suggests this dinosaur-bird link could fly
...ophisticated CT scanner. Ketcham then spent months removing artifacts that marred the images so the scientists could reconstruct the size and the features of the brain using 3-D modeling software. The upper bones that covered the creature's braincase were overlapped in the squashed fossil. Computer modeling ...Dispute over life in Antarctic lake
...d on the core sample, which involve washing it and removing the outer layers, would be completely effective. Brent Christner of the Montana State University in Bozeman has even tested for kerosene and other markers to distinguish the outside from the inside of the core. He is confident the cells he has found ...New discovery may help transplants survive
...r. In previous work, Dana and his team found that removing the lymph nodes that drain the eyes prevented rejection of transplants that were vulnerable. They also found that VEGFR-3, known to cause the growth of lymphatic vessels, was expressed on the APCs and new lymphatic vessels were present in the corneas...Study: A little help from friends makes wounds heal faster
... experiment, the researchers found that surgically removing the adrenal glands the main source of cortisol from some of the isolated hamsters was just as beneficial to wound healing as having a companion in the cage. Wounds on the stressed and non-stressed animals healed at the same rate, suggesting that co......cals or UV exposure. Because YY1 prevents p53 from removing pre-cancerous cells, YY1 represents a hitherto unsuspected candidate for a source of p53-inactivating mutations, as well as a potential new target for future therapies. According to the study published today in the Proceedings of the National Academ...Lake research offers clues to managing crayfish invasions
...e researchers note, may lead to new strategies for removing these trespassers. Details of the research will be...e ecosystem." To date, the promise of successfully removing rusty crayfish and restoring the habitat has been bleak. For example, bait traps tend to catch only ...Microarrays, key genome expression trackers, work better when probes are sequence-verified
...articular classification scheme but indicated that removing unverified probe sets allowed for the major component of change to be related to the underlying biology (in this data set, breast cancer) as opposed to the source of the experiments. "As combining data from multiple microarray platforms/technologies...How wounds heal Clues from flies
...to the injury. When you remove a scab, you're also removing some of the newly regenerated tissues growing underneath, thereby interfering with the healing process. Many different cell types and proteins have been linked to the repair process, but the complexity of the mammalian wound response has challenged e...ORNL nanoprobe creates world of new possibilities
...ment of the sample. This may consist of physically removing the sample and diluting it in a liquid containing silver nanoparticles; however, this practice is unnecessary with the ORNL nanoprobe. Vo-Dinh and Life Sciences Division colleagues David Stokes and Zhenhuan Chi experimented with nanoprobes made of se...Study finds plant enzyme function changes with location in cell
...sts will also explore the possibility of adding or removing address signals to/from known enzymes to see if they can change their locations and functions. "We are already using the chloroplast desaturase, without its address signal, to make a healthier, less saturated, plant oil in Arabidopsis," said Shanklin...ORNL adds three R&D 100s to DOE lab-leading total
...e, which is the preferred treatment technology for removing contaminants such as perchlorate from water. However, the resins often absorb chemicals other than those targeted for cleanup. They also become contaminated and must be disposed of, destroyed or stored, which is costly and often impractical. The rea......true genetic knockouts, with scientists completely removing both copies of a gene so 100 percent of function is gone or taking out one copy so the gene functions at half capacity, the MCG scientists cannot determine the exact gene activity level in their animal model. "These worms reflect what happens with re...