Cigarette smoke causes breaks in DNA and defects to a cell's chromosomes, Pitt study finds
.... Saunders. "The failure of the cell to accurately repair the cigarette smoke condensate-induced double-stranded breaks probably leads to anaphase bridge formation and chromosomal instability," added Li Z. Luo, Ph.D., a graduate student in the department of biological sciences, who will present the data. A...Molecular motor implicated in tissue remodeling
...riety of purposes from organ development to tissue repair to metastatic invasion of tumors," says senior aut...trix during tissue growth and development or wound repair or even during cancerous invasion of tissues. Because MMP-1 moves directionally, it can serve as a c...EMBO Gold Medal 2004 goes to Spanish scientist
...been diverse not only connecting telomeres to DNA repair and the cell cycle but also to chromatin epigenetics. Recent discoveries Most recently, the research group produced the first characterization of mammalian telomeric heterochromatin and the activities that regulate it. Other recent groundbreaking ...Trial shows which brain cancer patients benefit from temozolomide
...methyltransferase (MGMT) which is involved in DNA repair and its respective methylation status in the pati... MGMT gene is silenced and this means that no MGMT repair enzyme will be produced, thus preventing correction of faults in the DNA. Dr. Hegi, head of the lab...Researchers identify protein promoting vascular tumor growth
...wth," Gordillo said. "MCP-1 can be brought in as a repair response to help people with wounds, but it can make negative contributions to the health and well-being of people with tumors." Because angiogenesis is implicated in the development of other kinds of tumors and chronic inflammatory condi......gn systems able to promote tissue regeneration and repair (in disease, trauma, and during ageing) without the need for chemotherapy. These ideas may today seem science fiction, but to dismiss them too readily would be foolish. The risks and benefits must be carefully addressed to yield useful and safe techn...16 APS exercise research highlights, from reduced flu mortality to proteomics & obesity
...and characterize the discrete stages of the muscle repair process. 12.4 Natasha Frank, et al. (Children's Hospital Boston, Mass.) Expression of early developmental genes by human fetal skeletal muscle side population cells. Early developmental mechanisms may be preserved in later stages of muscle cell c...Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
...r growth factor producing cells (tissue growth and repair promoting cells). These cells have practical benefits over other sources of regenerative-capable cells such as bone marrow, skeletal muscle, embryonic and fetal tissue and rarer sources of stem cells. Additionally, regenerative cells from a patient's...Rice finds 'on-off switch' for buckyball toxicity
...tists what happens inside the body, where cellular repair mechanisms, whole-organ and whole-body processes come into play. "Cytotoxicity should not be confused with a full-fledged toxicological risk assessment," said Kevin Ausman, CBEN executive director and a co-author of the paper. "Risk assessments take ...Tufts University establishes $4 million dollar tissue engineering resource center
...edicine developed a tissue engineering strategy to repair one of the world's most common knee injuries -- ruptured anterior cruciate ligaments (ACL) -- by mechanically and biologically engineering new ones using silk scaffolding for stem cell growth. "This Center will help stimulate new economic g...NJIT professor receives Presidential Award for breakthrough research with adult stem cells
... a framework for stem cells, allowing the cells to repair bone as the biomaterial degrades. Arinzeh performe..., in combination with adult stem cells, might also repair cartilage, tendon and neuronal tissues. "This is a very exciting time to be doing stem cell research...New research suggests link between maternal diet and childhood leukemia risk
... legumes, and it plays a role in the synthesis and repair of DNA, as well as the detoxification of certain harmful compounds. Within the fruit and vegetable food groups, certain foods - including carrots, string beans and cantaloupe - stood out as having stronger links to lower childhood leukemia risk...Extreme stretch-growth of axons
...ying this knowledge to develop nerve constructs to repair nerve and spinal cord damage. "To find that tensi... actually good for your nerves for both growth and repair may not be such a long stretch," says Smith....How do you mend a broken heart?
...ts will investigate the ability of heart muscle to repair itself after being damaged by a heart attack, for example and to regain function. Prof. Rosenthal has previously shown that when a muscle is injured, stem cells can help the tissue rebuild. This team of researchers will build on her findings and us...Genuine stem cells found in skin might treat hair loss, wounds
...tists hope to advance on new therapies designed to repair or replace damaged tissues and organs, said the researchers. In mammalian skin, each hair follicle contains a reservoir of stem cells, known as the bulge, which can be mobilized to regenerate the new follicle with each hair cycle and to generate new ...Skin stem cells give hairless mice hair
...ll have the capability to perform either epidermal repair or hair-follicle generation." To answer those questions, Fuchs and her colleagues first isolated stem cells from the bulge by fusing antibodies to characteristic cell surface molecules. "An important aspect of this paper was that we found we could ...Protein involved in childhood disorder linked to cancer
...rological disorder also plays a role in DNA damage repair and thus cancer prevention. The research appear...s that delay the cell division cycle so that these repair systems have time to work. "Regulation of these protective processes is coordinated through the ac...How an insidious mutation fools DNA replication
...uld clog the Cheerio. Such malformations trigger a repair mechanism to correct the mismatch. The researchers' initial studies revealed that the polymerase biochemically "prefers" to mismatch an 8-oxoguanine with adenine rather than the correct cytosine. If not detected and corrected, such a mismatch leads ...Integrative biology of exercise APS Intersociety meeting October 6-9, 2004 in Austin
...of Exercise meeting Exercise-induced injury and repair of skeletal muscle: cellular and molecular mechanisms. Chair Dan Garry and Mike Lindinger. Genetic engineering and muscle performance. Chair Joe Metzger. Basic mechanisms contributing to physical inactivity-induced disorders. Chair Frank W. Boot...University of Pittsburgh receives $10 million grant for head and neck cancer
...es and Weissfeld will examine alterations in a DNA repair gene, XPD, and a cell cycle regulatory gene, cyclin D1, that previous research at UPCI has determined are significant predictors of head and neck cancer risk, as well as increased risk for lung cancer in smokers. The researchers will examine the inte...