Penn scientists identify novel pathway in aneurysms
...th in Penn's Center for Experimental Therapeutics, report their findings in this week's online publication and the September issue of Nature Medicine. Funk is now the Canada Research Chair in Molecular, Cellular and Physiological Medicine, Queen's University, Kingston, Canada. "This is the first time anyon...Asian elephant sex pheromone transporter revealed
...issue of Chemistry & Biology, Lazar and colleagues report an unexpected finding about pheromone transport in the Asian elephant, an endangered species of which only a few thousand individuals remain. Female elephants communicate their readiness to mate by excreting a sex pheromone in their urine. Male eleph...Scientists reinvent DNA as template to produce organic molecules
... complex synthetic molecules. The researchers will report on the prolific technique, dubbed "DNA-templated library synthesis," this week on the web site of the journal Science. "The basic structures of proteins and nucleic acids seem limited when compared with the structures that can be created using modern...Improved nutrition could reduce malaria burden worldwide
...tamin A, zinc, iron and folate, according to a new report by researchers with the Johns Hopkins Bloomberg School of Public Health. Their review of recent data from malaria endemic regions showed that improving child nutrition could prevent more malaria-related illnesses and deaths than previously thought. T...Study suggests cell-cycle triggers might be cancer drug targets
...ar, MD, and senior author Peter Sicinski, MD, PhD, report on developing the first mouse embryos to date in w... a companion paper in Cell, researchers from Spain report similar findings involving protein kinases called CDK4 and CDK6, which are molecular partners of the...Heartless worms hold clues to cardiac arrhythmias, sudden death
...m channel involved in the rhythmic heartbeat. They report the success of their approach in the Aug. 10 issue of the Proceedings of the National Academy of Sciences. The tool could lead to ways to prevent arrhythmias and sudden death associated with block of a potassium channel called HERG (Human ether-a-go-......he opposite slope. In 2002, the authors of the new report returned to the Chagres and the Rio Grande to collect fish. In total, they found that three fish species had colonized the Chagres Riverand five had colonized the Rio Grande. Both sides of the Isthmus became more species rich as a result of the Can...Researchers report new gene test for isolated cleft lip and palate
Researchers report they now can predict whether some parents are more...ip and palate. In the latest paper, the scientists report a so-called "haplotype" gene test, one of the first of its kind in medicine. A haplotype is the sum......ated to circadian rhythms, say the scientists, who report their findings in the latest issue of the journal Neuron. In addition to Kay and Hogenesch, authors on the paper include Satchidananda Panda, Ph.D., a graduate of Scripps Research's Kellogg School of Science and Technology and currently a postdocto...When is a mouse like a test tube?
...ical processes in biology." She and her colleagues report their novel chemical experiments - the first reaction in a living organism between two chemicals that don't react with the organism - in the Aug. 19 issue of Nature. In this particular experiment, they showed that they could use this type of chemica...The first engineering of cell surfaces in living animals
...s such a complex reaction vessel." The researchers report their results in the 19 August 2004 issue of Nature. Key to their success is what Bertozzi calls the bio-orthogonality of the reaction, literally "at right angles" to biology: chemical reactions artificially induced on the cell surface must be high...New mechanism for display of foreign proteins to immune system
...mmune system has sentinel cells whose job it is to report the presence of foreign invaders or cancers. In a process called crosspresentation, the sentinel cell internalizes foreign proteins, called antigens, from the environment and breaks them up into tiny fragments that are then displayed on the cell surf...Retroviral gene therapy? ASLV, HIV, and MLV show distinct target site preferences
... retroviral vectors derived from three viruses and report 3,127 sites where these viruses typically integrate into the human genome. The different vectors, they found, show different target preferences. Mitchell et al. studied vectors derived from the human immunodeficiency virus (HIV), avian sarcoma-leuko...Genes can influence both alcohol consumption and dependence
...n who reports high intake at one time is likely to report high intake at other times," said Whitfield. "How...with less extreme forms of alcohol dependence also report many alcohol-related problems, including relationship and employment difficulties, use of more alcoh...Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels
...e inhibitor. "As far as we know, this is the first report showing that ceramide depresses VEGF pathway by interfering with VEGF production," according to Guzmn. To answer the second part of the question relating to clinical tests, the scientists obtained tumor biopsies from two patients with glioblastomas w...Flame retardant levels much higher in farmed salmon
...onsumers should choose their salmon carefully. The report appeared online Aug. 10 in Environmental Science & Technology , a peer-reviewed journal of the American Chemical Society, the worlds largest scientific society. Polybrominated diphenyl ethers (PBDEs), which are used widely as flame-retardant additiv...Brain's reward circuitry revealed in procrastinating primates
...ng Liu, Ph.D., Edward Ginns, M.D., and colleagues, report on their findings in the August 17, 2004 Proceedings of the National Academy of Sciences, published online the week of August 9th. Richmond's team trained monkeys to release a lever when a spot on a computer screen turned from red to green. The ani...The telomere crisis: A crucial stage in breast cancer
...e University of California at San Francisco. Their report is now available through advance online publication of Nature Genetics. Joe Gray, director of Berkeley Lab's Life Sciences Division and a professor of laboratory medicine and radiation oncology at UCSF, is one of the paper's lead authors, with Koei ...Scientist who discovered Sly syndrome finds new research path to explore for treating the disease
... baby mice, but not of brains of adults. "Here we report that the blood-brain barrier of neonatal mice possesses a transport system for the enzyme that is progressively lost with aging. In fact by adulthood, the blood-brain barrier has totally lost this transport capacity." Until this discovery, researcher...More aggressive breast cancer tumors found in African American women
...ts than their white counterparts, Yale researchers report in the August 9, 2004 online edition of the journa...ene. "This is the first population-based study to report a clearly significant increase in p53 mutations that is independent of race differences in other tum...