Vertex Researchers Report Three-Dimensional Atomic Structure Of JNK3 Enzyme; Report In Structure
... to treatepilepsy and stroke. The discovery, which represents the first known structureof JNK3, will be published in the August 15, 1998 issue of the journalStructure. JNK3 belongs to the MAP Kinase family of enzymes, a group of proteins that helpto transmit signals from the surface of cells to the nucleus, al...Envisioning Ions With INEEL-Developed Simulation
...cularly appropriate nichefor a national lab. "This represents exactly the kind of thing a national labought to be doing," he says, "producing, developing and vigorously proliferatingtechnology so that the maximum number of people will benefit from the taxpayer'sinvestment." SIMION's beauty lies in its intuitive...Gene Therapy Animal Study Offers Hope For Some Neurodegenerative Diseases
...rof anatomy and ophthalmology at UCSF. The finding represents an important breakthrough in the still fledgling field ofgene therapy, which has been particularly challenged by disorders caused byabnormal, or mutant, proteins, so-called autosomal dominant diseases, saidLaVail. Most gene therapy approaches have fo...Cocoa And Chocolate Experts Convene To Discuss Sustainable Cocoa Production
... Latin America/Caribbean. "This conference represents a gathering of the experts who can trulymake adifference on the sustainability issue," notes ACRI Vice President Carol Knight,Ph.D. "By working together on a worldwide basis, we will be able to addresssustainabilityissues from a consensus position m...Team Solves X-ray Structure Of Powerful Enzyme
...spread of cancerthroughout the body. The research represents a milestone in an on-going UW Medical School effort tofully understand the large family of enzymes known as phosphoinositide kinases.The enzymes are usually located on the cell membrane, where they receive signalsfrom outside the cell. They relay the...Researchers Grow Healthy Human Placental Cells For Drug Research
...an placental cells in the laboratory. This represents a critical first step toward finding a way to test the safety of drugs that a woman can take during pregnancy without harming her fetus. The cells provide scientists with the means to observe what happens to drugs that pass through a he..."Lab On A Chip" For DNA Testing Invented By U-M Engineers
...recordresults---the self-contained "lab on a chip" represents an almost "hands free"technology. The team's success with the DNA-testing chip suggests that similar integratedsystems can be constructed at the nanoliter scale using sample and reagentvolumes far smaller than those needed in typical human or robotic...Scientists Sequence Chlamydia Trachomatis Genome
...t cannot make. "The Chlamydia trachomatis genome represents a molecular gold mine for theresearch community," says Dr. Stephens. "Even the establishment of a geneticsystem, which we can manipulate to study the organism, is within reach. Thiswould enable scientists to use molecular tools to investigate, for ...DOE Joint Human Genome Effort Exceeds Sequencing Goal
...inishedbases and 40 million "draft" bases. "This represents only the first step in our aggressive plan for productionramp-up. We are seeking to break the 100-million-base-pair barrier in the year2000," he said. Thus far, the international human genome sequencing effort hascracked only about 7 percent of the...Fully Endoscopic Brain Surgery At Cedars-Sinai Medical Center
...ight cavernous sinus -- a verydangerous area. This represents a venous pool of blood that houses the internalcarotid artery, one of the main sources of blood to the brain, as well as nervesthat go to the eyes. Without the endoscope, it would have been impossible to seearound the corner into this area, and it wo......logy to Targeted Genetics. "Adoptive immunotherapy represents a potentially powerful tool in the treatmentof infectious disease and cancer," says Riddell. "Previous studies havedemonstrated that T lymphocytes play a crucial role in eliminating virallyinfected or cancerous cells from the body. However, clinica...Subterranean Mapping Method Will Find Homes For Pollution-Eating Bacteria
...ome for pollution-eating bacteria. Their technique represents an important step toward better harnessing thebacteria to clean up heavy metals, organic chemicals, and radioactivecontaminants polluting soils and aquifers and threatening water supplies. Biogeochemist Robert W. Smith has been awarded a three-year $...A Protein Switch May Turn On Heart Cells To Combat Heart Disease
...he Rb gene active in their heart cells. While this represents an important step forward in manipulating cells in theheart to grow, MacLellan says researchers still must investigate how the Rb geneworks over time and whether these heart cells will multiply after a stress, suchas heart attack. Extending these stu...New Company Formed Through Licensing Of Cardiac-Hypertrophy Technology From Texas Institutions
...opment at UTSouthwestern, said formation of ManTex represents the new direction ofbiotechnology development in Dallas. "We are proud to participate in launchingManTex Biotech," Stone said. "The firm's founding technology will serve as abenchmark for additional biotechnology companies that will be formed as anou...Vitamin E Prevents Early Plaque Formation
...all cell membranes," Jialal said. This also represents the first demonstration that vitamin E has effects atthe nuclear level on an important transcription factor. It inhibited thetranscription factor NF-kappaB that is important for adhesion and inflammation.Jialal said they have elucidated the molecular...Memory Loss In Old Age No Longer Linked To Dying Brain Cells
... play any significantrole in memory. "It represents a real paradigm shift in neuroscience," Gallagher said."For years, peoplehave been trying to discover what caused the death of brain cells during aging.Our research has quite reversed that idea. We now know it's more important tounderstand the existi...Scientists Describe Structure Of An Enzyme That Uses Iron To Make Hydrogen
...ers. "The biologicalproduction of hydrogen, then, represents a tremendous reserve of energy that wemay tap through our understanding of the mechanisms that have evolved innature." Attaining the three-dimensional structure of enzymes like CpI may be thefirst step in tapping into that resource. ...AHA Issues Scientific Statement On Infective Endocarditis
...ut 20,000-30,000 people develop IE, a disease that represents the fourthleading cause of life-threatening infections such as pneumonia, according toKathryn A. Taubert, Ph.D., senior scientist in the AHA's department of scienceand medicine and a co-author of the statement. Individuals at risk for IE include peo...Antibody Revolution Targets STDs, Stomach Viruses, Common Cold
...ore immediately and moredirectly. "This represents a big shift in how the technology can be used," Whaleysaid. "A lot of the emerging infectious diseases are due to existing technology.Antibiotics, for example, are really part of the problem. We, as consumers,abuse antibiotics and doctors over-prescr...Wetting Of Structured Or Imprinted Surfaces - Zooming Down Onto The Nanoscale
...from theclassical Rayleigh-Plateau instability and represents a new type of wettingtransition between two different morphologies of constant mean curvature. Thislatter transition can only occur because the contact angles of the channel donot satisfy the classical Young equation. As far as applications are conce...