JCI table of contents September 15, 2004
...henever the transplanted stem cells stabilized and rescued the retinal blood vessels that would ordinarily co...rod cells, the cells that see black and white, the rescued cells after treatment were almost always cone cells, the cells that detect color. The researchers fu...Disease-resistant papaya saves Hawaiian papaya industry
...lly resistant to papaya ringspot virus (PRSV), has rescued the Hawaiian papaya industry and may have the potential to do the same in other papaya-growing regions of the world, say plant pathologists with The American Phytopathological Society (APS). "In 1992, Hawaii's papaya industry faced economic disaste...Commercialization deal boosts hope for new sickle-cell drug
...years. CHB's Intellectual Property Office rescued the technology and relicensed it to Icagen, Inc., a privately-held company in Research Triangle Park, N.C. Icagen, which focuses on ion channels as drug targets, did further chemical work to optimize the drug and sponsored Phase I and Phase II studi...Good bacteria trigger proteins to protect the gut
...y DSS. "These bacterial products completely rescued the commensal-depleted mice," said Medzhitov. "None of them even got sick, and when we analyzed their colons, they were healthy and normal. This was definitive proof that the beneficial effects of commensal bacteria were due to their recognition by T...NRH1 and Wnt signaling come together in convergent extension
...mily small GTPases. Loss of NRH1 function could be rescued by the co-injection of Frz7, a Wnt receptor functioning upstream of Rho, Rac and Cdc42 in the PCP pathway and, similarly, NRH1 complemented a dominant-negative Frz7 phenotype, indicating the two proteins play compensatory and mutually independent rol...Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy
... off the body's immune response, the research team rescued mice from the destruction of their pancreatic islet cells that causes Type 1 diabetes. The research was led by Kristin Tarbell, Ph.D., a postdoctoral associate in Rockefeller's Laboratory of Cellular Physiology and Immunology, headed by professor and...Study suggests possible way to repair damaged nerve cells
...ry," Yoon said. "But it's too soon to say if these rescued cells would function normally again after treatment. "We do know that injury decreased the number of healthy, viable neurons by half," she said. "But the number of intact neurons remained at nearly 100 percent after antibody treatment."...New roles for protein modifications in cell migration
...ctivity. The wild-type MIG-23 protein successfully rescued yeast mutants for NDPase, lending solid support to the case for the NDPase nature of MIG-23. The similarity between the MIG-23 and MIG-17 phenotypes suggested that the mutation of MIG-23 might result in abnormal MIG-17 glycosylation. Using gel elect...U-M scientists find genetic 'fountain of youth' for adult stem cells
... "Deleting p16 from the stem cells only partially rescued the ability of neural stem cells to self-renew," Morrison. "This indicates that Bmi-1 likely regulates multiple different pathways that are important for stem cell self-renewal."...Watching social behaviour evolve
...arming defects of these mutants, however, could be rescued by the mere social presence of their fibril-producing parents. When cultured alone on a plate, the fibril-deficient mutants swarm very poorly. When mixed as a minority with their adhesive, fibril-constructing parents, they swarmed much further than t...Splitting hairs: GATA-3 function in hair follicle development
...ave matured. As suspected, these pharmacologically rescued GATA-3-null mice did, in fact, show a number of ab...malies. The whisker follicles of pharmacologically rescued GATA-3-null mice were oddly bent, and displayed irregular thickenings and delayed emergence through ...How a little bit of cold can kill a big manatee, and what it might mean for the species
...s should improve efforts to treat and rehabilitate rescued manatees with the syndrome. Instead of dealing with each symptom in the sick manatees, and potentially releasing animals in need of further care, Dr. Bossart says now rehabilitators can deal with the overall syndrome, which is physically far-reaching...Protecting vessel loss in the eyes of premature infants
.... It had been shown previously that vessels can be rescued by administration of VEGF, suggesting that VEGF might be used in the treatment of ROP. However, this theory presents a double-edged sword as VEGF also stimulates abnormal vessel growth that can ultimately result in leaky vessels. In order to wisely s...JCI table of contents, July 1 2003
.... It had been shown previously that vessels can be rescued by administration of VEGF, suggesting that VEGF might be used in the treatment of ROP. However, this theory presents a double-edged sword as VEGF also stimulates abnormal vessel growth that can ultimately result in leaky vessels. In order to wisely s...Fetal death, miscarriage linked to genetic mutation
...mental problems associated with Rb mutation. These rescued mice had been largely cured of anemia and showed no abnormal cell death in the brain. Through embryonic manipulation, Michael Robinson, a member of the OSUCCC as well as a professor in the department of pediatrics at Ohio State, created a tetraploid......nts effectively down-regulated Wnt1 expression and rescued the headless phenotype. "It is clear that small differences in the expression of Wnt proteins along the future brain region are critical for the determining the final identity of the different brain territories. We have now determined that in the mo...Ovary gene may explain certain aspects of infertility
...y ovaries transplanted into Fmn2-deficient females rescued pregnancy loss, whereas transplant of Fmn2-deficient ovaries into healthy females destroyed the healthy females' ability to produce offspring. Furthermore, examination of the experimental mice revealed a radically reduced number of embryos in Fmn2-d...Fragmentation may be linked to local amphibian extinctions
...is the means by which declining populations may be rescued or recolonized following extinction," say the researchers. However, little is known about how habitat disturbance affects the dispersal of juvenile amphibians. Rothermel and Semlitsch studied the movements of three types of juvenile amphibians (spott...Adult stem cells selectively delivered into the eye and used to control angiogenesis at TSRI
...iferated, forming new blood vessels. This actually rescued and stabilized the retinal vessels when they would otherwise be degenerated. They also found that they could shut down the angiogenesis by first transfecting the stem cells with a powerful inhibitor of angiogenesis--a fragment of the human protein tr......ults In the experiments involving shock, some rats rescued with hyperbaric oxygen revived and survived at lea...es (4 of 10 rats). The last series of 10 rats were rescued using a revised protocol, which kept them warm after their return to the cage. The surviving animals...