UF researcher: gene therapy effective in animal studies of Parkinson's disease
...n the part of the brain where the dopamine neurons reside (the substantia nigra) or in the striatum. In a third group, they were inserted in both areas. The gene copies were carried into the cells by recombinant adeno-associated virus, or AAV, a vector that so far has not been linked to any adverse effects ...Scientists identify gene that causes fatal lung disease
...eviewing the hundreds of genes which were known to reside in the region of chromosome 2q linked to PPH. Lane recognized that BMPR2 is a member of the TGFb family. The first mutation of BMPR2 was demonstrated by DNA fingerprinting in the labs of Dr. John A. Phillips III, David T. Karzon Chair in Pediatrics. ...Scientists map first structure in important family of proteins
...ns that have been analyzed so far are soluble, and reside inside a membrane....Hair follicles provide the stem cells for the skin's entire epidermis
...the University of Pennsylvania School of Medicine, reside in a well-protected area of the follicle, called the "bulge," that lies just underneath the skin. The new study, led by Tung-Tien Sun, Ph.D., of NYU School of Medicine, and Robert Lavker, Ph.D., of the University of Pennsylvania School of M...Artificial muscles release medicine from tiny implants
...l devices. He has developed tiny sensors that will reside on the outside of the plastic capsules to sense concentrations of certain chemicals in a patient's bloodstream. When sensors detect that a patient needs medication, the artificial muscles will shrink away from the holes in the wall to let medicine p...Biodiversity databases: biodiversity information on every desktop
...y are either scattered in many local databases, or reside on paper or other media not amenable to interactive searching. GBIF is a new framework for facilitating the digitization of biodiversity data, for compiling the data into searchable databases (both existing and newly formed ones), and for ensuring co...The role of science in restoring California's water resources
...e live.`` In fact, most Californians reside in the southern part of the state, in arid desert communities such as Los Angeles, Anaheim and San Diego. And California`s multibillion-dollar agriculture industry - which produces 45 percent of America`s fruit and vegetables - is concentrated in the......related to the earliest stages of sperm production reside not on the male sex (Y) chromosome as expected, but on the X chromosome, a chromosome universally thought of as the female sex chromosome. The finding, published in the April issue of Nature Genetics, comes as a big surprise and is causing scientist...New molecular key to disposal of dying cells
...avenger cell that circulate throughout the body or reside in tissue and ingest dead tissue and degenerated cells. Together with the genes Axl and Tyro3, Mer comprises a family of molecules known as receptor tyrosine kinases, which serve multiple functions in different tissues. Scientists at the UNC School o...Evolution at a snail's pace: It's faster than you think
...excellent fossil record, as do most organisms that reside in shallow ocean water. Hellberg performed all the genetic testing in the study, and Roy and Balch performed the fossil analyses. "We each had very different techniques," Hellberg said of himself and his colleagues. "And it turned into a very pro...The world's most powerful NMR spectrometer
...ed by the shape of the molecule in which the atoms reside by their proximity to other atoms in the molecule. An NMR spectrum is unique for a particular molecule, and the structure of a molecule can be determined from its spectrum. ...Homing in on better bone marrow transplants
...poietic progenitor cells (HPCs). The HPCs normally reside in bone marrow, and serve as the source of all new blood cells. HPCs also circulate in the bloodstream. They find their way back to the bone marrow by attaching to a protein called E-selectin, which is made by cells that line the blood vessels. The s...How brain cells remember their birth order
...ces where in the developing brain those cells will reside permanently. In an article published in the August 24, 2001, issue of the journal Cell, Howard Hughes Medical Institute investigator Chris Q. Doe and colleagues at the University of Oregon reported that Drosophila neural precursor cells, called neuro......uctivity, entire species of plants and animals who reside in lower and more fertile areas are left largely unprotected. For example, past studies have shown that the greatest numbers of amphibian and reptile species in the western United States are found below 2000 meters, while many reserves are confined ...New epilepsy gene identified in mice
...diogenic epilepsy, where mutations were thought to reside at multiple loci, the Frings mice appeared to be unusual because their mutation was in a single locus. After narrowing their search, Ptacek and his colleagues then set out to map this locus finely enough to identify the specific causative gene. "It w...Findings on cell communication may help fight three genetic diseases
...s protein, which binds ribonucleic acid (RNA), can reside in either the nucleus or cytoplasm. It is thought to move repeatedly between the nucleus and cytoplasm and may convey critical messages as it does so. As in Huntington's disease, it is therefore essential to understand how its transport is normally c...APS August/September journal hot picks
...n BSEP that result in PFIC-II during infancy might reside in sequences common to sBSEP. Moreover, as 32 percent of the sBSEP sequence is not conserved in human BSEP, and functional studies suggest that sBSEP and mammal BSEPs have identical properties, it is likely that the non-conserved sequences may not be...Morphine-like drugs could offer relief for amputees
... injured nerve fibers. Phantom pain is thought to reside in the brain. When the part of the brain that controlled the limb before it was amputated no longer has a function, other areas of the brain fill in. The Hopkins data supports that theory, in that lidocaine, a drug that predominantly works on the p......al forms of these molecules, called prion protein, reside on the surface of brain cells, although no one knows their proper function. Abnormal prion proteins are the likely cause of the brain damage that occurs in TSE diseases. Scientists believe the misshapen prion proteins somehow induce normal prion pr......nce the sodium ions show a reduced propensity to reside near the modified region of the DNA molecule, there is nothing there to effectively modulate and gate the motion of the positively charged electron holes. That reduces the probability of charges moving across the modified region." Beyond th...