Master of antimalarial resistance
...ations after gradually creating strains of malaria resistant to halofantrine and amantadine treatment. As resistance to these two drugs increased, however, the parasites lost their resistance to chloroquine. This unusual pattern--gaining resistance to one drug while simultaneously losing resistance to another-...Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
...mutations in the shape of this protein can make it resistant to the antibiotics called sulfa drugs. These findi...at a variety of other infections that are becoming resistant to these drugs. The team made these discoveries by creating images of the molecular structure of DHP...'Smart antibiotics' may result from UCLA research
...antibiotics is that bacteria can mutate and become resistant to a particular antibiotic, while the antibiotic i...ing the mechanism we discovered, to kill the newly resistant bacterium." The use of bacteriophage to treat infections is not in itself a new idea. "Phage ther...Scientists discover potential new way to control drug-resistant bacteria
...ges to treat bacterial infections that have become resistant to antibiotics. "This serendipitous finding un...for developing drugs and vaccines that can control resistant bacteria, which are a growing public health concern," says David L. Klein, Ph.D., who oversees bacte...New way to protect brain from stroke damage
... a functional copy of the ASIC gene were similarly resistant to stroke damage, they found. "Our study offers mu...-permeable type of the acid-sensing channels, were resistant to acid injury. To test that activation of ASIC1a is involved in ischemic brain injury in a live ani...DuPont developing new protective suits for military, first responders
...h the development of protective materials that are resistant to chemical and biological agents. The suits are ...w Orleans. In addition to traditional DuPont fire resistant materials, DuPont TM Nomex and Kevlar, these new, lightweight suits contain a selectively permeable...A new protein is discovered to play a key role in cancer progression
...is disrupted. Primary cells from Pml-null mice are resistant to TGF-b dependent growth arrest, induction of aging (cellular senescence), and cell death (apoptosis). However, when PML function is added back to these cells, this defect is corrected and TGF-induced activity restores normal cell functions. "The......ly identically in terms of concentration, but it's resistant to proteases and it can penetrate the cell membrane just like other small molecules," said Dowdy, who is at the University of California, San Diego School of Medicine. The result of the search for Smac mimics was a molecule the researchers called "Co...Molecular staples shape a cancer killer
...tical lead compounds. By making the peptides more resistant to degradation and enabling their cellular uptake,... specifically activate the cell death program in a resistant cell," said Walensky. "For example, certain lymphomas are specifically driven by BCL-2 overexpressio...... mice that were deficient in Stat3 were completely resistant to skin tumor development. The authors further showed, both in cell culture and in live animals, that they could block growth of already transformed skin cells if they inhibited Stat3 function using an oligonucleotide inhibitor. Additionally, when ...JCI table of contents: 1 September, 2004
... mice that were deficient in Stat3 were completely resistant to skin tumor development. The authors further showed, both in cell culture and in live animals, that they could block growth of already transformed skin cells if they inhibited Stat3 function using an oligonucleotide inhibitor. Additionally, when ...Other highlights in the September 1 JNCI
...ut the drug can also make some neuroblastoma cells resistant to chemotherapy. Because fenretinide, a derivative of retinoic acid, targets a different molecular pathway--one that induces apoptosis, or programmed cell death--in neuroblastoma cells and is well tolerated, there has been interest in using fenretini...Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
...hallenges given an increasing prevalence of highly resistant microorganisms, the emergence of new microbes and the existence of large numbers of immunosuppressed individuals in whom standard antimicrobial therapy is often not effective," says Ekaterina (Kate) Dadachova, Ph.D., assistant professor of nuclear me...Study of flu patients reveals virus outsmarting key drug
... then we may be faced with the rapid appearance of resistant viruses," Kawaoka says. At present, there are only... can be a source of another infection, possibly by resistant viruses," he says. Oseltamivir is a well-known drug and is widely used in Japan. Its use in the Uni......infection with another HIV virus including viruses resistant to drugs. This infection with a second HIV virus i...y and co-author of the study. "These emerging drug resistant viruses present a treatment challenge and the existing drug cocktails will need to be tailored accor...Streptococcus infects humans by thwarting blood clotting
...mutate our plasminogen so it still worked, yet was resistant to a bacterial streptokinase, it would give us an advantage," said Ginsburg. "But then the bacteria could mutate their streptokinase to keep up. So, you can see how one bacterial species and one host get locked in this evolutionary dance and would ev...Strep disrupts blood clotting to infect humans
...mutate our plasminogen so it still worked, yet was resistant to a bacterial streptokinase, it would give us an advantage," Ginsburg said. "But then the bacteria could mutate their streptokinase to keep up." The findings also suggest that subtle variations in plasminogen genes among humans may explain why some...UC Irvine scientists to develop vaccine to combat bioterrorism threat from deadly bacteria
...Institutes of Health. B. pseudomallei , which is resistant to many antibiotics, causes melioidosis, an infectious and deadly disease that affects humans and animals. At present, no vaccine against melioidosis exists. "The development of a vaccine against B. pseudomallei is a national and worldwide goal, an...JGI announces community sequencing program portfolio
...ons in the U.S. alone. Sequencing of an antibiotic resistant form of this organism will inform how antibiotic resistance occurs. Sequencing of groundwater samples from contaminated sites within the Oak Ridge National Laboratory Y12 Security Complex. The site contains one of the highest concentration plumes o...No longer just for biology, RNA can now be built into 3-D arrays
...ed RNA building blocks. The arrays are stable and resistant to a wide range of environmental conditions, such as temperature, salt concentration, and pH." Peixuan Guo From experts at NSF: "The discovery of this viral RNA machine is quite remarkable and provides yet another example of the flexibility and vers...