Gene-disabling techniques simplified by Stanford team
...e cells to become cancerous or alter how the cells respond to different drugs. These genes could then become potential targets for drugs to treat disease. A paper in the same issue of Nature Genetics described a similar way of creating siRNA libraries. "Having two unrelated groups working on the same problem...New device can help defend against novel biological agents
...iosystems Research and Education. "But how will we respond if one of these groups uses recent advances in genetic engineering to produce an agent that is new and unknown?" Part of the answer, Cliffel says, is the device he and his colleagues have developed, called a four-channel microphysiometer. It is a mod...Gene essential for development of normal brain connections resulting from sensory input discovered
... Petri dish are stimulated with calcium ions, they respond by developing highly branched dendrites, but neurons taken from mice lacking CREST fail to branch in response to calcium. "CREST is the first example of a transcription factor-a protein that turns genes on and off-that appears to be specifically req...Asthma could be several diseases masquerading as one
...s with early-onset asthma were also more likely to respond positively to allergens in a skin test and to have had eczema, an allergic skin disease. Although early-onset patients had had the disease, on average, almost twice as long as the late-onset patients, lung function was slightly worse in the late-...Beagle 2 fails to call Mars express
...e. Hopes were high that Beagle 2 would receive and respond to commands sent by Mars Express as it flew over the presumed landing site at around 12.15 GMT. Not only was Mars Express flying over Isidis Planitia at an altitude of just 220 miles (350 km), giving it an ideal listening position, but it was the fir...Cells' ability to open blood's floodgates hinges on unexpected factors
...controls blood flow. There are other mechanisms to respond to stress, hyperventilation, blood pressure alterations or other dramatic changes. "What we're doing is isolating the response in blood flow when the brain function itself changes and using that response as a window for investigating brain metabolis...Study by UCSD gives new insight into how anthrax bacteria can evade a host's immune response
...sence of anthrax toxin, human immune cells fail to respond normally to lipopolysaccharide--a component of the cell walls of many bacteria including the bacteria that cause anthrax, Bacillus anthracis. Bacterial invasion, or the presence of lipopolysaccharide, usually causes immune cells known as macrophages ...Ocean life depends on single circulation pattern in Southern Hemisphere
...tion pattern with an eye to examining how it might respond to global warming in model simulations."...Desert dust enables algae to grow
...boratory results to predict how algae in the ocean respond to desert dust. The data obtained from these predictions will contribute to knowledge about the further development of the greenhouse effect, because algae absorb the greenhouse gas carbon dioxide and in so doing slow down the warming up of the Earth...Oral drug showing promise for breast cancer prevention in a mouse model
...s are not dependent on estrogen to grow and do not respond to antiestrogen drugs such as tamoxifen and raloxi...d to identify patients and healthy women likely to respond to gefitinib as a therapeutic and chemopreventive agent," they conclude....Ohio State creates first gene chip for horse
...e chips let researchers see how thousands of genes respond to an illness. This information can be used clinically to study disease in horses and in translational research from horse to human. "The closer we can demonstrate that an animal model really mimics a human disease, the better off we are," said Berto...Researchers identify key player in respiratory memory
...w or airways are blocked, for example - our bodies respond accordingly. In the case of oxygen deprivation, th...stem remembers the disruption and most likely will respond more vigorously in the future. Researchers call this change in neural behavior "neuro-plasticity." I...Discovery of brain disorder gene paves way for genetic test
...s. Integrins are responsible for cells' ability to respond appropriately to their external environments. That clue led the team to search the second genetic region linked to CCM for aberrant genes resembling KRIT1's known protein binding partner. Nine families with the "type 2" form of CCM harbored eight d......oks as though sensitive people are simply wired to respond to stress more strongly than resilient people," Naliboff said. "How someone reacts to stress seems to be more important than the stress itself in explaining why one person gets sick and one person doesn't." "This heightened stress response is the equ...Alcoholics with antisocial personality disorder have blunted emotional reactivity
Emotional reactivity refers to how people respond to pleasant and unpleasant events. New research ha...holism. Emotional reactivity refers to how people respond to both pleasant and unpleasant events, including ones that cause physical and mental stress. A stu...SARS coronavirus part bird, part mammal: study
...l allow us to design more effective treatments and respond more effectively to future outbreaks," says Guttma...s new viral form, it is more difficult for them to respond to it in a timely and effective manner." Similar genetic exchange events are believed responsible fo...Chemical gradient steers nerve growth in spinal cord
...sponding to Netrin and Sonic hedgehog but begin to respond to a new set of proteins, known as Slits and Semaphorins, that repel them, shifting the axis of growth away from back to front (dorsal-ventral) and toward top to bottom (anterior-posterior). At that point, Wnt proteins take over, drawing the axons up...A little stress may be good for you
...levated levels of special protective proteins that respond to stress in a cell (known as molecular chaperones) promote longevity. Acute stress triggers a cascading reaction inside cells that results in the repair or elimination of misfolded proteins, prolonging life by preventing or delaying cell damage. ...Microscopes provide new view for tissue engineering
... into three-dimensional tissues. Whether the cells respond and organize as intended in this synthetic environment depends greatly on the composition, properties, and architecture of the scaffolds' porous interiors. Tools for simultaneously monitoring microstructure and cellular activity can help scientists t...Story tips from the Department of Energy's Oak Ridge National Laboratory
... function and how individual proteins interact and respond to various stimuli. The National Heart, Lung and Blood Institute of the National Institutes of Health is specifically interested in defining the function of genes relevant to cardiovascular function and has awarded $15 million to a team led by the Me...