ALL survivors bear genetic damage from life-saving chemotherapy
...common pediatric malignancy, but many ALL patients respond well to chemotherapeutic interventions. Since the 1960s, the five-year survival rate for children with ALL has increased to almost 80 percent. Patient remission and long-term survival is credited to the development of national standardized chemothera...Oxford Journals takes bold step towards free access to research
... listening to all communities involved in order to respond appropriately in the future." Oxford J... listening to all communities involved in order to respond appropriately in the future." ...Mice with hyperactive Wnt10b gene eat all they want, but have half the body fat of normal mice
...nd adiponectin, which affect the body's ability to respond to insulin. Reduced insulin sensitivity is one of the first symptoms of diabetes. So having little or no white fat is just as devastating to your health as having too much fat." "Even though the Wnt10b transgenic mice had half as much adipose tissue ...Yale scientists decipher odor code
...t has lost its original odor receptor and does not respond to any odors. Using genetic engineering, Hallem ...rs activated only one. Some receptors are able to respond in different ways to different odors activated by some odors and inhibited by others. "We were a...A fly's taste experience is much like our own
...ound in mammals, where there are 35 receptors that respond to bitter substances and three that respond to sweet, with members of the two sets never expressed on the same nerve cell. To determine whether ...Melting ice cap gives urgency to new census of marine life project in Arctic Ocean
... species are urgently needed to help policy-makers respond appropriately to the consequences of changes in the ocean."...Targeted therapy for lung cancer patients shows promise in extending lives
...tumor can be evaluated to see which patients might respond better. "This therapy is being tested in patients ...ble us to identify patients who are more likely to respond and to have a favorable response. We are looking to achieve tumor shrinkage with minimal side effect...Flies may taste bitter better, first map of insect 'tongue' reveals
...t looks like a pair of lips covered in bristles -- respond to either sweet or bitter flavors, much like cells...sensory nerve cells bearing receptor proteins that respond to particular compounds. Geneticists have proposed that many if not most of the tasting abilities in......cer treatment methods. "We'll see how the tumours respond and determine the best treatment strategy to use on patients if they carry the Mus81 mutation," said Hakem. "We're hoping to activate the proteins and cellular pathways that can efficiently kill tumours carrying Mus81 mutations."...Study helps explain island populations' susceptibility to exotic diseases
...helps scientists understand how island populations respond to invasive parasite species. The introduction of exotic parasites and diseases through travel, commerce and domestic animals and the resulting destruction in native wildlife populations is a worldwide problem, Foufopoulos said, but it's even more se...Whole body imaging allows better understanding of the immune system
... to actually watch as immune system cells find and respond to tumors or infection. Compared to the snapshot views of the immune system from tumor biopsies or blood assays, this whole body imaging allows scientists to track how the immune response changes, and the tumor or infection responds, throughout the d...Scientists discover molecular target for treatment of T cell acute lymphoblastic leukemia
... important discovery, as these particular patients respond poorly to current chemotherapies and are at high risk for treatment failure," says Dr. Kelliher....Two billion vulnerable to floods by 2050; number expected to double or more in two generations
...EHS), strengthening the capacity of governments to respond to natural disasters, and establishing sustainable...curity, there is an urgent need to reassess how we respond and prevent the potential of catastrophic loss of life and economic damage from natural disasters," ...Drunken worms reveal a genetic basis of alcohol response
...ting subtle genetic differences among strains that respond differently, researchers have identified one gene that affects alcohol sensitivity. In an article in the June 10, 2004, issue of Neuron, Andrew Davies and his colleagues describe their findings that subtle differences between worm strains in t...All ecosystems are equally productive under drought conditions
...such as deserts or wet tropical forests, would not respond much to variations in precipitation. Not ...experiments to see how various types of ecosystems respond to different levels of precipitation. Huxman is doing so by simulating different-sized rain events o...Common worm provides insights into salmonella virulence
...o them. The ability of its innate immune system to respond appropriately to specific bacteria is very similar to that of mammals. "The goal of our research is not only to better understand what makes a particular pathogen harmful for the host, but to determine those characteristics of the host that either ma...Sex-specific differences in gene expression related to drug metabolism and hypertension
... implications for explaining how males and females respond differently to drug treatments and sex-specific propensities for high blood pressure. Interestingly, the adult hypothalamus had very few sex-specific genes, despite its role as the control center for behavior. This was not only the case in the mouse...Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy
...emical processing, and relay messages about how to respond to other immune system cells. Through this biologically didactic process, dendritic cells can either encourage T cells to attack or to tolerate a huge variety of antigens. "Extensive research has allowed scientist to learn that these T regulatory ce...Researchers identify genetic markers to predict response to chemotherapy for colorectal cancer
... predictors of how well colorectal cancer patients respond to this drug and how severe side effects will be," Carlini said. To see how genetic variations affected response and side effects, the laboratory analyzed DNA in blood samples taken during a multi-site clinical trial to test an investigational ...Gene expression ratio identifies risk of recurrence in breast cancer patients receiving tamoxifen
...which estrogen-receptor-positive patients will not respond to tamoxifen treatment," says Dennis Sgroi, MD, director of Breast Pathology at MGH who led the hospital's research team. "Identifying those for whom tamoxifen is likely to fail could allow physicians to choose other drugs, for instance the aromatase...