Molecular marker predicts success of breast cancer treatment
...tely, nearly 40% of breast cancer patients fail to respond to tamoxifen or eventually become resistant to tre...r patients who will be less likely to successfully respond to tamoxifen and would therefore benefit from an alternative therapeutic strategy for treatment of e...Tamoxifen stimulates breast cancer growth following alteration of estrogen receptor
...only about half of ER+ breast cancers successfully respond to treatment with tamoxifen, while the other half ...e a critical determinant of how ER+ breast cancers respond to tamoxifen. "This is highly relevant for breast cancer patients, since tamoxifen might induce the ...Biologists discover nerve activity, not just genetics controls kinds of neurotransmitters produced
...ders would depend on the ability of these cells to respond appropriately to the new neurotransmitter. Further research is also needed, the UCSD scientists say, to determine if the 50 to 100 other known neurotransmitters are also regulated by activity. Other UCSD contributors to the publication were Cory Roo...UCSD study shows how we perceive world depends on precise division of labor among cells in brain
...at different neurons in the brain are dedicated to respond to specific portions of the information. "Our...oncert to allow these brain neurons to selectively respond to a specific pattern of incoming electrical impulses. Communication across the connections between...UNC scientists block cellular enzyme activity involved in cancer progression
...of tumors," Schaller said. One way cells sense and respond to their environment is through receptor molecules called integrins, which are located on the cell's outer surface. FAK relays signals from integrins to other molecules inside the cell that ultimately control the growth, survival and movement of the ...Concerns remain about UVB damage to amphibians
...e in Ecology, a professional journal. In it, they respond to some recent studies that have called into question whether UV-B radiation is causing severe health problems or mortality in amphibians. "At this point, we believe the broad body of research conclusively demonstrates that UV-B radiation can cause ...Cell growth and death controlled by single pathway in lymphoma cancer model
... of Sciences, helps explain why some people do not respond to chemotherapy and offers a possible solution. Th... the stomach and usually arises when B lymphocytes respond to inflammation provoked by the bacterium Helicobacter pylori (H. pylori). Infection by this bacteri...Pharmacogenomics could replace 'trial-and-error' with science from the human genome
...omics is its ability to predict how a patient will respond to medications by identifying individual polymorphisms, or variations, in specific genes that contribute to that response. Pharmacogenomics can also help investigators discover more effective drugs, such as anti-cancer agents. "Some genes are over-e...Study suggests double punch could more efficiently kill viruses
...causing agents such as viruses. For the T cells to respond to a viral infection, "professional" antigen-presenting cells (pAPCs) must present small pieces of viral proteins, called peptides, on their surfaces. This triggers a seek-and-destroy response in T cells. There are two pathways through which to activ...Molecular image of genotoxin reveals how bacteria damage human DNA
..."since the immune system requires cell division to respond to microbial infection." There are nearly 10 different species of disease-causing bacteria that use CDT, including Salmonella typhi, a bacteria that causes typhoid fever; Haemophilus ducreyi, a bacteria that causes genital ulcers; Campylobacter jejun...Genomic biology institute's first grant to focus on soybeans, climate change
...rs already know that the various types of soybeans respond differently to environmental influences, but they've been unable to identify the mechanisms that drive such responses. Such new approaches may help them to do so. "Eventually, by using these new and developing genomic technologies, agronomists may b...Study helps satellites measure Great Lakes' water quality
...e engineers said. Lakes are important because they respond much faster to climate change than oceans do, Mupparthy said. Erie is the warmest of the Great Lakes, the shallowest and richest in life, and has changed much in recent years. For instance, the lake has experienced a microcystis outbreak every summer...Insight into transplant rejection might lead to novel prevention therapies
...with receptors like TLR4 built in to recognize and respond to foreign pathogens. Further understanding their role in transplant should greatly enhance physicians' ability to prevent and treat clinical rejection." The team will conduct additional studies to further elucidate the interaction between the innate...Small trial shows daclizumab add-on therapy improves MS outcome
... patients with multiple sclerosis (MS) who did not respond to interferon alone found that adding the human antibody daclizumab improved patient outcome. Patients who received the combined therapy had a 78 percent reduction in new brain lesions and a 70 percent reduction in total lesions, along with other si...20 May AAAS lecture: Computers that Respond to Human Emotion
...archers are building computers that can detect and respond to a person's emotions. Prototypes can measure emo... such as facial expressions and voice changes, and respond with human-like skills such as listening, empathy and sympathy. The research and technology behind ...New insight into how tumors resist radiation
...ecent studies have shown, however, that tumors can respond to radiation by secreting factors that promote the survival of blood vessel cells. Dr. Mark W. Dewhirst and colleagues from Duke University Medical Center have investigated the activation of this protective response and whether the process can be suc...Gene maps of simpler life forms point the way to human disease gene
..., which create motion, and non-motile cilia, which respond to motion," she says. "The microscopic worm C. elegans only has non-motile cilia, so if we were to take our results from this study and eliminate all the genes that have a match in the genetic code of C. elegans, that might let us highlight genes for...Study examines future of species extinction, conservation
... a whole and the individual species within it will respond to environmental degradation, according to results published in the May 13 issue of Nature. With extinction continuously altering the fates of plants and animals, the researchers say it may be extremely difficult to predict which organisms will be th...Earth, sky tapped in unique global climate change study
...eeks so far," Volder added. "We thought they would respond but not so much, so fast." The juniper's response points to the fact that global climate changes could mean some species would take over the region to the detriment of others, the researchers note. "This type of information may give us an idea of w...Oak Ridge National Laboratory to develop DOE leadership-class computing capability for science
...OE Office of Science laboratories were eligible to respond to the solicitation. The department determined that a national laboratory was the logical place for a national computational user facility for capability limited science, because at such a venue the DOE Office of Science can ensure world-class oper...