Avastin-Tarceva combo provides 'one-two' punch against lung cancer
...umab (Avastin TM) and erlotinib (Tarceva TM). The response rate proportion of patients whose tumors shrank i...was 12.5 months. This compares to about 10 percent response and between six and eight months median survival with traditional therapy or erlotinib alone, said A...Gene expression ratio identifies risk of recurrence in breast cancer patients receiving tamoxifen
...only two thirds of these patients have a prolonged response to the drug. "Until now, there has been no way to predict which estrogen-receptor-positive patients will not respond to tamoxifen treatment," says Dennis Sgroi, MD, director of Breast Pathology at MGH who led the hospital's research team. "Identifyin...Molecular marker predicts success of breast cancer treatment
... morphological changes and became more invasive in response to growth signals. "This suggests that HOXB13 may directly contribute to tumor invasion and metastasis," explains Dr. Sgroi. The researchers conclude that the HOXB13:IL17BR expression ratio may provide an effective molecular marker for identifying br...Biologists discover nerve activity, not just genetics controls kinds of neurotransmitters produced
...e synapse receiving the neurotransmitter change in response to being exposed to a different neurotransmitter. Using changes in activity to treat neural disorders would depend on the ability of these cells to respond appropriately to the new neurotransmitter. Further research is also needed, the UCSD scienti...When blood can't get to brain, special CT scan helps
...flow. Those patients whose vessels don't dilate in response to acetazolamide, because they're already maximally dilated and letting as much blood through as they can, are most likely to benefit from a blood flow augmentation procedure. Perfusion CT can also help during a balloon-test occlusion, in which docto...UCSD study shows how we perceive world depends on precise division of labor among cells in brain
...ical impulses by triggering the appropriate muscle response to escape the stimulus. "This study advances our understanding of how the brain reads a code made of identical electrical impulses, in order to produce a coherent perception of the world," he says. "Deciphering the language of the brain will help u...Drug that cuts off tumor's blood supply extends lives of colorectal cancer patients
...of death by more than 30 percent. It also improved response rates, duration of response and progression-free survival times, said Dr. Fairooz Kabbinavar, a Jonsson Cancer Center researcher...Beware cancer, insomnia and liver disease UH students are taking aim
...s of Figueroa's research show that pupillary light response studies could provide a useful system for high throughput screening of drugs that regulate mammalian circadian rhythms. This would be a more cost-effective approach to the more traditional phase shift experiments that are time-consuming and costly t...JCI table of contents, 1 June 2004
...ic flow alterations dictate leukocyte adhesion and response to endovascular interventions AUTHOR CONTACT: Yora...products (RAGE) is involved in the immune system's response pathways, but its specific role in the innate and adaptive immune response pathways remains unknown....Other Highlights in the June 2 JNCI
...ancer A new study shows how testing for an immune response to the prostate cancer biomarker alpha-methylacyl-...low to be detected. To determine whether an immune response to AMACR could be used instead as a biomarker for prostate cancer, Arul M. Chinnaiyan, M.D., Ph.D., ...Clemson researcher receives Komen grant
...t cancer drug Herceptin, which has only 30 percent response rate. Chen will use the Komen Foundation funding to further establish the molecular bases of the combination of PRL antagonist and Herceptin . "We hope that our research results will soon be translated into clinic and contribute to the battle against...Pharmacogenomics could replace 'trial-and-error' with science from the human genome
...al factors: multiple genes might influence patient response to the drug; there might be interaction with other drugs given simultaneously; and the seriousness or rate of progression of the disease as well as diet and activities such as smoking might affect treatment outcome. "Despite the enthusiasm researche...Study suggests double punch could more efficiently kill viruses
...s on how to boost or improve the body's own T cell response to the virus." CD8+ T cells play an important role...n their surfaces. This triggers a seek-and-destroy response in T cells. There are two pathways through which to activate the T cells. In one pathway, called dir...Does antibiotic use contribute to allergies?
... can promote the development of an airway allergic response following allergen exposure via the nose," says Noverr....U-M scientists use 21st-century technology to probe secrets of M. tuberculosis
...edical School. "It's the immune system's fail-safe response to infection. If the immune system can't clear the...coming more common. The immune system's immediate response to the presence of M. tuberculosis in the lungs is to surround the bacteria with immune cells called...Antibiotics alter GI tract microbes and increase lung sensitivity to allergens
...rborne allergens and particulates. This triggers a response from immune cells in the GI tract to generate regu...em modulates or dampens down the allergic T cells' response to incoming allergens in the lungs, according to Huffnagle. But when antibiotics reduce the bacteria...The search for a safer smallpox vaccine: New data released on promising candidate
...ed, or modified, so that it can initiate an immune response without causing serious adverse side effects. LC16m8 is designed to have a better safety profile, yet be equally effective, compared to conventional smallpox vaccines. Buller's research is one of two research studies conducted to support the efficacy...Gene at root of urban air pollution's lung effects
...tance of genetic factors in determining the lung's response to environmental toxins by pinpointing a key playe... of asthma," said Hollingsworth. "While the body's response to environmental exposures can facilitate the clearance of pathogens, it can also lead to injury and...Insight into transplant rejection might lead to novel prevention therapies
...new suite of drugs aimed at suppressing the innate response in the lung could significantly improve patient ou...the gene had earlier been linked to a reduced lung response to bacterial toxins. Recipients with a single copy of either of those two TLR4 variants exhibited a ...Cancer drug resistance research leads to possible therapeutic target for Alzheimer's disease
...d understanding cellular pathways that affect drug response and resistance. The new report concerns the human ABCA2 transporter, one of a large family of ATP-binding proteins that transport a variety of molecules across biological membranes. ATP (adenosine triphosphate) is present in all living cells and ser...