Tag: "response" at biology news

Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin

...ulated vaccine that will induce the optimum immune response possible in animal models. ...

New discovery may help transplants survive

...connection or 'pathway' that stimulates the immune response in the eye and in other parts of the body," says R...g from inflammation (caused by a full-blown immune response to the original injury or disease), rejection rates go well over 50 percent, regardless of the thera...

LSU Vet School receives $9.9 million for infectious disease research

...cal Sciences, LSU College of Basic Sciences; "Host response in HIV-1 and microsporidia co-infection," Hollie Hale-Donze, Ph.D., Department of Biological Sciences, LSU College of Basic Sciences; "Monocyte infection in SIV neuropathogenesis," Marlene Orandle, DVM, Ph.D., Department of Pathobiological Sciences, ...

Activated signaling pathway may predict lung cancer patients' response to gefitinib

...ug gefitinib (Iressa) was associated with a better response rate, disease control rate, and time to progressio...alled Akt and MAPK--may be involved in a patient's response to gefitinib, Federico Cappuzzo, M.D., of Bellaria Hospital in Bologna, Italy, and colleagues, looke...

Other highlights in the August 4 JNCI

...HER-2/neu overexpression does not lead to a poorer response to chemotherapy in women with metastatic breast ca...R-2/neu overexpression is associated with a better response to anthracycline-based chemotherapy, but its association with response to taxane-based chemotherapy ...

JCI table of contents, 2 August, 2004

...lerosis, the authors found that an adaptive immune response against this peptide was initiated, and that this ...the interaction of the natural and adaptive immune response and the immune system's ability to protect against atherosclerosis. TITLE: IL-5 links adaptive and n...

Genetic discovery could dramatically reduce need for liver transplants in children

...liary atresia are prone to develop an inflammatory response against themselves, according to Dr. Bezerra. The study suggests that these inflammatory cells see the biliary system as a foreign target. Proof of this concept, however, requires additional studies. To determine how inflammatory cells obstructed bi...

Another key for the p53 door

...as a transcription factor to cause cell suicide in response to DNA damage. "In terms of possible therapies for the future, YY1's regulation of p53 at different levels means that we have new, different targeting options," says LICR's Dr. Johan Ericsson, the senior author of the study. "We know that we can use ...

New technique helps scientists reveal interactions between genes and drugs

..., demonstrated by higher numbers of cell deaths in response to low drug doses. The robot also highlighted cell lines with high resistance to the drugs where few or no cells were killed. In the future, patients whose cells are particularly sensitive to chemotherapy may be able to be treated with relatively...

In search of a lean gene

... but whether JIP1 plays a more general role in the response of the body to stress is unclear. One form of str...emonstrates that JIP1 plays a critical role in the response of the body to the stress caused by obesity. Drugs that target the function of JIP1 to regulate JNK...

A changing landscape may have dire implications for birds

.... Forest Service, details broad patterns of birds' response to housing growth and land cover change in the lower 48 United States. The bottom line, according to UW-Madison researchers Anna Pidgeon and Chris Lepczyk, is that as rural forested landscapes are developed and parsed by roads and openings for new ho...

Two-pronged attack targeting EGF receptor hinders cancer cell growth

...ations of the EGFR drugs may further enhance tumor response and potentially benefit more patients who currently don't respond to a single EGFR inhibitor, Harari noted. Recent clinical trial results with the EGFR inhibitor erbitux combined with radiation in head and neck cancer show clear improvement in patien...

Spring through fall, cities are greener longer than neighboring rural regions

...set show that urbanrural differences in vegetation response are a function of land surface temperatures, showing a significant linear trend between change in greenup and change in temperature. The trend generally shows that greenup advances three days for each one degree Celsius increase in temperature. Thi...

Study finds anti-HIV protein evolved millions of years before the emergence of AIDS

...heir surprise, that the protein began to evolve in response to such Darwinistic pressure more than 30 million ... looking for proteins that are rapidly evolving in response to selective pressures we can identify candidates that participate in conflict," Malik said. "Some o...

Epilepsy: Signals 'brake' in brain impaired

...peded the ERK with specific substances, the signal response of the nerve cells largely normalised. The findings therefore make it appear possible to discover new therapeutic approaches. 'Admittedly, the ERK has so many tasks to do that there would probably be side-effects if it was impeded directly,' says Hei...

Misfiring proteins tied to inflammation and sick feeling of type 2 diabetics

...is found in type 2 diabetes mice. The neuroimmune response leading to the sickness behavior, Freund said, was linked to hypersensitivity to lipopolysaccharide and potentially to cytokine resistance. Now Freund is asking what this signaling breakdown in the insulin receptor substrate does in patients. "Such ...

Growing new breed of vaccine-producing plants to fight human diseases worldwide

... tissues to animals or humans results in an immune response to the subunit vaccines," Arntzen commented. Arntzen's research focuses now on producing vaccines in tomatoes to fight human afflictions such as cholera, Norwalk Virus and hepatitis B. Norwalk Virus is a major cause of gastrointestinal i...

Children's Hospital Boston receives more than $10 million to help make smallpox vaccine safer

...atitis, explore different components of the immune response to the vaccinia virus used in smallpox vaccine, se...he researchers hypothesize that an abnormal immune response in the skin makes people with atopic dermatitis susceptible to EV after smallpox vaccination. Dr. H...

Good bacteria trigger proteins to protect the gut

...the intestine is believed to mount an inflammatory response to benign, or commensal, bacteria. The researcher...ut TLRs in mammalian systems has to do with immune response to infection," said Medzhitov. "We thought that since these mice couldn't mount a TLR-dependent infl...

K-State researcher working to improve alternatives to equine antibiotics

...produced by the body as an immediate immunological response to pathogens and generally target and kill bacteri... antimicrobial peptide production and other immune response factors that help ward off infection," Davis said. "What it would mean is we hope we could use shor...

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