UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases
...ngenital abnormalities of the kidneys, a condition resulting in large, fluid-filled cysts that lead to kidney failure. Since it is largely unknown what triggers these cysts to form, Dr. Igarashi and his colleagues used a mouse model to express a mutant form of HNF-1 similar to the form in humans with MODY5. Th...Alcohol consumption can damage hearing
... alcohol consumption can lead to brainstem damage, resulting in hearing degradation. Although alcohol researchers believe that drinking can cause brain damage, the quantity of alcohol and the length of time needed to accomplish this remain unknown. In the March issue of Alcoholism: Clinical & Experimental R...Scientist works to interrupt early changes resulting in diabetic vision loss
...s documenting the dramatic reduction in cell death resulting from the injections of the ligand, Pentazocine. "We have a long way to go, but nevertheless, I think it's quite promising," Dr. Smith says....Gene links hereditary intestinal disorder with stroke danger
...od vessels to sprout into capillary beds normally, resulting in the vascular deformities seen in patients with HHT. A similar mechanism is thought to underlie the vessel lesions in patients with the earlier established HHT genes. Collaborators in the research included Gabriela Repetto, M.D., of the Universidad...Newly cloned gene key to global adaptation of wheat
...e vernalization genes and were selected by humans, resulting in spring varieties better adapted to certain regions. Last year, Dubcovsky and colleagues reported detailed genetic and physical maps for the VRN1 region in wheat, rice and sorghum. By comparing the sequences from these species, they determi...Possible link discovered between gene responsible for blood vessel development and ACD in newborns
... this deficiency caused major defects in the lung, resulting in respiratory distress and death. Tests showed that small blood vessels and capillaries were not formed properly and there was a misalignment of pulmonary veins, features that are shared by newborns with ACD. "We know from past research that eNOS i...Breaking the rules on artifical blood
...h polyethylene glycol to make them bulkier, so the resulting fluid is thicker, or more viscous, than normal blood. The coating also gives MP4 a higher affinity for oxygen than other substitutes. Studies have shown that MP4 releases oxygen in the capillaries, as intended. This week Sangart announced that a sma...Researchers find a protein that controls cell growth
...can propel a cell into uncontrolled proliferation, resulting in cancer. Dr. Pagano says that his laboratory plans to ascertain whether there are mutations in the gene encoding the APC protein that cause Skp2 to accumulate. (If APC were mutated, then the instructions for Skp2 degradation would be missing). If ...Rimonbant shows promise in addressing multiple risk factors
...ecreased ability of the body's cell to use insulin resulting in impaired glucose control) increases the risk of diabetes and cardiovascular disease. The RIO-Lipids study investigated rimonabant's effect on improving insulin sensitivity using a standard test to measure glucose control, the Oral Glucose Toleran...Common virus may contribute to uncommon bone disease in children
...cytes, the body mounts an abnormal immune response resulting in the overproduction of Langerhans cells seen in LCH," said Mr. Glotzbecker. The researchers confirmed the presence of the virus with in situ hybridization, a testing technique. The virus, HHV-6, is extremely common in children and adults, but usual...Key gene identified for development of inner-ear structure required for balance
...ations, infections and injury can damage otoconia, resulting in vertigo and other balance problems. Discovering the role of NADPH oxidase 3 could aid researchers seeking a way to regenerate otoconia in humans. Bergstrom says he and his Jackson Laboratory colleagues enjoyed an exceptionally productive collabora...Baker's yeast rises from genome duplication
... time it divides, but did not split it between two resulting cells, or two cells may have fused. The result is that a yeast cell with around 5,700 genes suddenly had more than 11,000. In this scenario, while one copy of the gene performs its designated function, the other is free to perform a new and potential...Faulty DNA replication linked to neurological diseases
...h causes progressive damage to the nervous system, resulting in symptoms ranging from muscle weakness and speech problems to heart disease. The DNA triplet that repeats in Friedreich's ataxia is a guanine and two adenines (GAA) on one DNA strand and the complementary two thymines and a cytosine (TTC) on the op...New DVD 'virtual' microscope at UNC-Chapel Hill
...t. It's a very critical part of the process." Each resulting image is gigabyte size. Images are then encoded and compressed with computer programs developed that assure minimal loss. This viewing program is known as MrSid, the acronym for multi-resolution seamless image database.The new DVD is cost-effective. ...Rensselaer awarded $2.7 million NIH grant to improve drug development process
... evaluate each compound is expensive and slow. The resulting bottleneck in drug development has attracted considerable attention among researchers seeking to advance more efficient and affordable processes. Dordick and the team are proposing a novel set of techniques that will, if successful, remove this bottl...Human health, astronomy, and environmental concerns merge at Dark-Sky meeting
...bout his work on the effects on light exposure and resulting melatonin levels on the growth of human breast cancer cells. Observatory directors from the Northern and Southern Hemispheres will talk about dark skies for research. Using beautiful images from the southern skies, Malcolm Smith, Cerro Tololo Observ...First ever legal challenge filed against the patenting of an animal
...beagles to radiation, drugs, and forced infection, resulting in a fatal illness," added Leary....New study seeks to establish mechanism between areas of the brain and continence
...cations for those patients with fecal incontinence resulting from a cerebrovascular accident and injuries to the frontal lobe. Background Voluntary control of the external anal sphincter (EAS) plays an essential role in maintaining fecal continence, or the ability to retain the body's waste material until th...Embryonic pig cell transplants halt rat diabetes
...as cells divide readily in response to such needs, resulting in a potentially expandable source of insulin. For reasons not yet understood, the transplanted pancreas cells did not develop an additional digestive function normally associated with the pancreas. "That was another remarkably ...UC San Diego faculty receive funding from von Liebig Center to commercialize academic research
... of network and device conditions and constraints, resulting in a rich wireless surfing experience. Wireless network operators as well as content providers and aggregators already have expressed interest in this technology. This grant will enable Dey and his team to make this software more commercial-ready a...