New Cancer Switch Discovered By Duke Medical Center Pharmacologists
...form of GRB-2 could suppress activation of ras and reverse the cancerous growth of human leukemia cells in test tubes. "These results suggest that inhibition of GRB-2 interactions may provide a useful therapeutic target for treatment of [chronic myelogenous leukemia] as well as other tyrosine kinase-associat...Heat-loving Microbe Repairs Its DNA With Light
... abundant, visibleportion of the sun's spectrum to reverse the harmful effects ofthe UV that sunlight also contains. On the other hand, Grogansays it seems ironic that the first example of DNA repair to beobserved in S. acidocaldarius works on UV-induced DNA damage, andnot the damage expected to be caused ...Researchers Find Possible New Route to Making Cancer Cells Vulnerable
...that stop organ transplantrejection also partially reverse drug resistance in certain cancer cells. Such resistance, which thwarts cancer chemotherapy, is a principal causeof death for cancer patients. The scientists have identified a new targetto stop drug resistance in cancer cells. The researcher...Duke's Russian Laser Making Ultraviolet Light And Gamma Rays
..., though, scientistshave been unable to study that reverse reaction because gamma ray beamsfrom other sources have lacked enough intensity, said Henry Weller, anotherDuke physics professor and TUNL researcher. Because gamma rays are generated more efficiently inside its optical cavity,the OK-4's gamma inten...Cornell Scientists Find Way To Boost Rice Crop Yield -- They'll Walk On The Wild Side
...recently developed genetic techniques. We hope to reverse the genetic erosion and selectively enrich the genetic base of crop plants. Results from this research demonstrates that genes in wild rice and other wild relatives of crop plants can do spectacular things. All we're doing is using modern technique...Genetic Trickery Offers New Way to Target HIV
...c template,providing a foothold so that the enzyme reverse transcriptase can copy the viral genetic code. Ini...ks at a different site on the HIV template,causing reverse transcriptase to begin copying at the wrong spot. Just like a typist whose fingers are off by one ke...Research Team Discovers Key Gene For Telomerase Enzyme In Humans
...oviruseslike HIV also belong to this class. Since reverse transcriptases share acommon amino acid sequence, they are expected to have similarthree-dimensional structures. This indicates that variants of "inhibitorssuch as AZT developed for treatment of AIDs may be able to inhibittelomerase," Nakamura said....Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...long to the same general familyof molecules as the reverse transcriptase enzyme produced by the HIV virus tha...we already know a great deal aboutthe structure of reverse transcriptase inhibitors," Dr. Counter says. "We havea good starting point for developing anti-telo...B-Vitamins Lower Homocysteine Levels In The Blood; May Reduce Vessel Damage In Stroke Patients
...on. "A short-term vitamin intervention can reverse the homocysteine-mediatedadverse effects on blood-vessel cells," says Richard F. Macko, M.D., of theBaltimore Veterans Administration Medical Center and assistant professor ofneurology and geriatrics at the University of Maryland. "It is remarkable ...Transplanted Neurons Restore Function In Rats After Stroke
...redfrozen, could be used as replacement therapy to reverse the deficits of stroke,"notes Virginia M.-Y. Lee, PhD, a professor of pathology and laboratory medicineat Penn and a coauthor on the study. Lee and Penn colleague John Q. Trojanowski, MD, PhD, also a professor ofpathology and laboratory medic...Yale Announces New Biotech Firm
...ly prescribed medication in a class ofdrugs called reverse transcriptase inhibitors. Zerit was the fastestgrowing product for this major pharmaceutical firm in 1997, achievinggrowth of more than 185 percent on its way to reaching worldwide sales of$398 million. Millions of people with the HIV virus have be......erapeutic interventions that would seek to stop or reverse themetabolic alterations on these degenerative diseases, according to Phelps. On January 1, he said, the federal government began reimbursingphysicians who used PET scans for diagnosing and staging ......ases, induce apoptosis (programmed cell death) and reverse theoverexpression of HER-2/neu, a cancer-causing gene. In patients with cancer,overexpression of the HER-2/neu oncogene is correlated with poor prognoses,increased tumor formation and metastasis and resistance to chemotherapeuticagents. Naoto T. U......erthat resembles itself," says Delville. "And the reverse may occur when thestressed hamster encounters a meeker hamster." The researchers plan to test their theory further by examiningvasopressin and serotonin activity in hypothalamus samples taken from thestressed hamsters while they were...Retinoic Acid Used In Cancer Treatment
...stead to arrest growth. "Retinoic acid can reverse the defect in growth control that was caused by the viral agent and result in cell-growth arrest," Yen says, describing his experiments with cell cultures. "Now we need a deeper understanding of how retinoic acid causes these changes -- and exactly ...New Sunspot Cycle To Be Bigger Than Average
...n about11 years. Because the solar magnetic fields reverse at the peakof each 11-year cycle, solar activity cycle actually spans a 22-year"Hale cycle." Cycle 23 is the last half of the currentHale cycle (composed of Cycles 22 and 23) that began in 1986. "The consensus [among solar physicists] is that this c...Possible Trigger For Heart Failure Identified In Lab Animal Studies
... inhibit the production or action ofTNF prevent or reverse heart muscle dysfunction and damaging "remodeling" inresponse to the molecules' errant assault on the failing human heart, Bristowwrites. Co-authors with Bryant in Dallas are Lisa Becker, B.S.; JamesRichardson, D.V.M., Ph.D.; John Shelton, B......al response. Finally, the researchers were able to reverse the decreased antiviral responsethat followed treatment of macrophages with anti-CD86 neutralizing antibodies byexposing the CD8+ cells to anti-CD28 antibodies, which are able to carry out thesame function as the CD86 molecule. "These studies indicat......ivity of the frog receptor. On the other side, the reverse procedure produced a human receptor with the ligand-selectivity of frog CRF-R1. From these results it was concluded that the identified region is part of the ligand-binding site of human and frog CRF-R1 and tha...