Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
... any specific genes for autoimmunediseases such as rheumatoid arthritis, although many researchers believethere ...earch institutions of an experimental treatmentfor rheumatoid arthritis (RA) that also uses antibodies to TNFa, Blackshearsaid. Such studies have shown antibodies...Molecular Piracy Turns Protein Into Traitor
...s it may also be a useful tool in diseases such as rheumatoid arthritis or asthma where the human immune system ... to useful anti-inflammatory agents for asthma and rheumatoid arthritis....New Form Of Gene Therapy Holds Promise For The Future
...apsingand remitting inflammatory diseases, such as rheumatoid arthritis, and organtransplant rejection. "Our long-range goal is to give patients the right amount of ananti-inflammatory protein, at the right time and in the right place, to controldamaging inflammation by introducing the gene for the prot......e a variety of clinical conditions ranging from rheumatoid arthritis to diabetes. They are known to often ...her autoimmune conditions, such as diabetes and rheumatoid arthritis, disease with important clinical as well as socio-economical implications....UPMC Researchers Report On Gene Therapy Advances
...he painfulinflammation and debilitating erosion in rheumatoid joints. After January 1996FDA approval, researchers injected cells genetically engineered to block theaction of IL-1 directly into selected RA patients' joints. This gene encodesthe interleukin-1 receptor antagonist protein, or IL-1Ra. Seven of th...Three-Dimensional Structure Of Human Lung Tryptase Determined, An Enzyme Involved In Allergic Asthma
...flammatory disorders such as asthma, psoriasis, rheumatoid arthritis, interstitial cystitis, and multiple sclerosis. Tryptase has been implicated as a causal mediator of such disorders and its involvement in the pathogenesis of asthma has recently been supported by preliminary results of clinical......issue damage when produced in excess such as in rheumatoid arthritis, transplant rejection, multiple sclerosis, organ failure or septic shock, and also promotes HIV production in monocytes. Due to TACEs role in TNF a conversion, inhibitors of TACE would affect the release of soluble TNF a ...First Evidence That Localized Arthritis Gene Therapy Heals Distant Diseased Joints
...his landmark study, conducted in a rabbit model of rheumatoid arthritis, appear in the April 15 issue of the Proceedings of the National Academy of Sciences. It is a major advance in the quest to bring arthritis gene therapy into widespread clinical use. "This offers the first evidence that arthr...Naturally Produced Enzyme May Be Useful In Inflammatory Arthritis
...novial fluid from the joints of threepatients with rheumatoid arthritis. The researchers then added NEP to thefluid and found that NEP decreased the negative effect of the inflammatorypeptide bradykinin. While NEP could potentially be used as a drug, its high cost and thedifficulty of delivery to inflame...Space Grown Insulin Crystals Provide New Data On Diabetes
... syncytial virus, sickle cellanemia, hepatitis and rheumatoid arthritis....Naked DNA Rejuvenates Rheumatoid Rodents
...A) tested the TGF-plasmid in a rat model for human rheumatoid arthritis. In this model, animalsthat are injected in the abdomen with a preparation of bacterial cell walls soondevelop swollen and inflamed joints in the feet. The acute arthritic phaselasts several days and then develops into a long-term chronic...Researchers Identify A Protein Critical For T Cell Development And Activation
...ficiencydisorders and autoimmune diseases, such as rheumatoid arthritis, diabetes andsystemic lupus. Activation of the specialized receptor for foreign substances, the T cellantigen receptor, starts a cascade of biochemical events that lead to T cellactivation. This cascade involves the activation of proteins ...NASA Research Helps Map Protein Structures -- Key In The Development Of New Disease-Fighting Drugs
...cancer, diabetes, sickle-cellanemia, hepatitis and rheumatoid arthritis. While ground-based research has been (historically) vital to thediscovery of protein structures, in the near-zero gravity environment of spaceresearchers have produced some of the largest, highest-quality protein crystalsever, whic......for drugs to fight inflammatory diseases including rheumatoid arthritis,Crohn's disease, physical wasting, and graft-versus-host disease. The proteinmay help counteract the ill effects when the body produces excessive amounts ofanother protein key to fighting infection. In proper balance, a bodily prot...UNC Researchers Reduce Arthritis Severity By Turning Off Molecular Switch
...establishan important molecular mechanism in human rheumatoid arthritis. The findingsdemonstrate the feasibility...ine and the ThurstonArthritis Research Center. "In rheumatoid arthritis, the delicate synovial joint lining dramaticallyexpands and transforms into an aggressive,...Immortalizing Enzyme Does Not Make Human Cells Cancerous
...;cartilage cells for those with osteoarthritis and rheumatoid arthritis; bloodvessel-forming cells for cardiac patients with angina, stroke or arterialinsufficiency; skin cells for burn patients and patients with severe wounds;muscle stem cells for treating muscular dystrophy patients; and the cosmeticproductio...Autoimmune Diseases Study Shows Differences Between Men And Women
...ree times as many women get multiple sclerosis and rheumatoid arthritis eachyear, compared to men, and for systemic lupus erythematosus, women outnumber mennine to one. "One of the big problems we faced was that very few people do studiesthat are specifically directed at differences between the sexes re...Researchers Engineer A Way To Improve T-Cell Receptors
... autoimmune diseases such as multiplesclerosis and rheumatoid arthritis. Scientists around the world have been refining a variety of monoclonalantibodies -- proteins similar to those that occur naturally in the immune systemthat search for and bind to specific antigens -- since the 1970s. However,similar refin...New Gene Holds Promise For Controlling Crohn's And Other Inflammatory Diseases
...self - includingperiodontal disease, septic shock, rheumatoid arthritis, lupus, Crohn's disease,and diabetes. "We believe this discovery offers new insights into how the body regulates thefundamental pathway involved in inflammation and opens up new ways to find andto treat currently untreatable diseases, " ex......gen-induced arthritis in mice, which is similar to rheumatoid arthritis inhumans. Polyphenols are chemicals that...sease. Instead, physicians control the symptoms of rheumatoid arthritis withpain relievers and anti-inflammatory medications, which in turn slow the damageto the ...