Tag: "ribosomal" at biology news

Proteins Interacting With RNA And DNA Are Surprisingly Similar

...n works by attaching to both theL11 proteinand the ribosomal RNA of infection-causing bacteria, preventingthe productionof protein and controlling the bacterial infection. But, although a nearly identical protein also is attached to theribosomes ofhigher forms of life, the antibiotic will only bind to thebacte...

MIT Biologists Identify Aging Mechanism

...from one of its chromosomes, that extrachromosomal ribosomal DNA (ERC)replicates until the cell becomes overwhelmed and dies. Aging in yeast cells isstarted by the formation of that first ERC. "The best part is, it's obvious it's a clock," said Leonard Guarente,Professor of Biology, referring to the E...

Three-Day Treatment Cures Decades-Old Case Of Malaria

...-making factories in all living things. Using the ribosomal RNA as a guide, he made largequantities of the genes that code for ribosomal RNA, then applied genetic "probes" that sought out and highlighted only genes that occur in one type...

The Bug Stops Here

...sbetween microorganisms is the sequence of the 16S ribosomal RNA gene. "This gene has conserved regions and very variable regions," saysDewhirst. The conserved, unchanging sections allow the researchers to zoom in onthe informative gene. From there, they can analyze the variable sections todetermine wh...

New Study Shows Group Of Marine Bacteria Dominate Offshore Waters Of Southeast, May Play Key Role In Ecosystem Processes

... "The target for our work is called the 16S ribosomal RNA gene," saidMoran, "and it's a good gene to foc...s takes place, and they are composedof specialized ribosomal RNA (which is abbreviated rRNA) molecules. The genescoding for rRNA are an essential component of th...

Biochemists Gain Crystal-Clear Insight into 'Ancient' Enzyme

... ribonuclease P helps activate another RNA, called ribosomal RNA,that is central to the cell's protein-making machinery. In their experiments, the University of Pennsylvania researchers producedcrystals of the ribonuclease P protein, and obtained the protein's structurethrough the widely used analytical metho...

Researchers Uncover 3-D Structure Of Virus Replication Technique

... materialfor its own purposes via a process called ribosomal frameshifting," explainsKamal Shukla, director of ...ch features of the pseudoknot formation facilitate ribosomal frameshifting byintroducing mutations or changes in the pseudoknot. Viruses have developed ingeniou...

Landmark progress in understanding ribosome structure-- research done at Brookhaven Lab's light source

...chers were able todifferentiate a protein from the ribosomal complex. In addition, the surfacetopology of both...venNational Laboratory. The research on the large ribosomal 50S subunit isreported by Nenad Ban, Poul Nissen, Peter B. Moore and Thomas A. Steitz fromYale Unive...

UCSC researchers obtain first detailed images of a complete ribosome

...per describes a molecularbridge in which a loop of ribosomal RNA projects from the large subunit andinteracts with a protein component of the smaller subunit. "Understanding how the subunits interact is critical to understanding how theribosome works, and for the first time we've been able to identify the prot...

Advanced light source reveals secrets of ribosome structure

...er RNA interacts with the ribosome, and howthe two ribosomal subunits interact with each other. In both cases t...ving interactions with a third type of RNA, called ribosomal RNA -- asort of bridge between the subunits. "One gets the impression that there are system...

Key progress by Weizmann scientists in the race to unravel ribosomal structure

...cientists hasdetermined the structure of the small ribosomal subunit at the highest resolution ever achieved,in...ly encoded instructions from the cell nucleus, the ribosomal factory churnsout proteins - the body's primary component and the basis of all enzymatic reactions. ...

'Frozen pictures' allow far-reaching glimpse into the cells protein factory

The structure of the small ribosomal subunit has been determinded at the highest resolu...ilization of functional probes, have unraveled key ribosomal features including the site where protein biosynthesis begins (PNAS 7 December 1999). The study, mad...

Protein found in yeast and humans appears to play a key role in regulating cell growth

... for reading the genetic code, to pump out lots of ribosomal RNA, which is part of the cellular workbench that ...s the proteins necessary for cell growth. The more ribosomal RNA produced, the faster the cell grows. "Rrn3 is absolutely essential to RNA polymerase I activity...

Yale researchers solve structure of the ribosome: groundbreaking achievement 'like climbing Mount Everest'

...ibiting the protein synthesizing activity of large ribosomal subunits in disease-causing bacteria, while leavin...es. "Now that we know the structure of the large ribosomal subunit," Steitz said, "we can determine its exact structure with antibiotics bound to it." The same...

New fossil find pushes age of terrestrial fungi back 60 million years, to the same era when green plants pulled themselves onto land

...curator at the University Herbarium. They compared ribosomal RNA from many species of fungi and calibrated them against geologic time to obtain an approximate time estimate for the origin of fungal lineages. They concluded in a book chapter published this year in The Mycota (vol. VII B) that the major lineages...

Science's Top 10: genome sequencing named top scientific advance of 2000

...gh the large unit of the ribosome consists of both ribosomal RNA (rRNA) and proteins, researchers found that the "active site" on the ribosome--the site of the chemical reaction that changes genetic information into the beginnings of a protein--contains only rRNA. This suggests that the ribosome is actually a ...

New images reveal the workings of cellular protein factories

.... The new paper provides further confirmation that ribosomal RNA is the active component in protein synthesis. ...ems to take place at the interface between the two ribosomal subunits. Noller and his coworkers identified 12 chemical bridges linking the two subunits, mostly i...

Identifying novel small RNAs

... as RNAs. Eukaryotic sRNAs are largely involved in ribosomal RNA processing and modification. Previously identi...r of cellular processes, but none of which involve ribosomal RNA biogenesis. This apparent difference between eukaryotic and prokaryotic sRNA functionality has ...

Better computer modeling provides a new look at large biomolecules

...o microtubules. The electrostatic model of the two ribosomal subunits -- one with 88,000 atoms and the other with 94,854, revealed an intricate map of positive and negative potential that could yield insights into the function of ribosomes, said the scientists. According to McCammon, software using the new app...

Scientists uncover the exact mode of action of five antibiotic drugs

... for years. Using their extensive understanding of ribosomal structure, Prof. Ada Yonath, Dr. Anat Bashan and P... designed to better target bacterial agents at the ribosomal level....

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