Duke Researchers Call Gene Therapy A Promising Strategy For Sickle Cell Anemia
... replacedefective genes in the genome, Sullenger's ribozymes correct defective RNA, themessage copied from DNA. Many genetic diseases, such as sickle cell anemia, arecaused by defective genes that get made into defective protein. Simply addingback a normal gene to cells doesn't decrease the amount of the "bad"...Interdisciplinary Method Offers New Way To Study Ribozymes
...professor of chemistry. "Studying the structure of ribozymes is extremely important in understandinghow they ca...omplexes and in large metalloproteins, thestudy of ribozymes has proven difficult. In contrast to the high metal-bindingaffinity commonly found in protein activ...Scientists Invent Faster Gene Function Identification System
...nt," Wagner says. Until now, studies using ribozymes as the catalyst to stop proteinproduction have worked only in cells. Wagner's research is the first to work inanimals. The scientists chose zebrafish instead of mice because of their fastgrowth rate -- the fish are adult size within 24 hours after th...Gene Shears In Cutting Edge Anti-Aids Trial
...yne Gerlach that naturally-occurringenzymes called ribozymes (dubbed "gene shears") can be used selectivelyto c...ases. Research is also well-advanced into uses of ribozymes in the agriculturaland food industries. For example, a range of virus-resistant vegetablecrops deve...Duke Researchers Show "Editing" Can Fix Faulty Genes In New Approach To Gene Therapy
...te itback together again. Sullenger reasoned that ribozymes could be adapted as atool to recognize defective mRNA and splice in a corrected version. To accomplishthis, he turned to the first ribozyme discovered, from the single-celledorganism Tetrahymena thermophila . This ribozyme not only cuts otherpieces ...