Master of antimalarial resistance
...chloroquine-resistant malaria. Fidock said pfcrt's role in halofantrine and amantadine resistance was "a b...resistance to another--may shed light on the exact role that pfcrt plays in resistance, according to Fidock and colleagues. When a human is infected with ma...No role for simian virus 40 in human pleural mesotheliomas
...ma samples and found no evidence for a significant role for SV40 in human mesotheliomas. Unexpectedly, they found that the SV40 DNA fragments detected in some assays were not derived from genuine SV40 in the tissue samples but from SV40 DNA fragments engineered into common laboratory plasmid vectors used ...A long-necked sea predator from China described in Science
...losaurus' long neck presumably served a functional role in hunting and present two possible strategies. With its long slender neck and small head, the reptile may have been able to sneak up and lunge at a fish or other aquatic prey in murky near-shore waters before the predator's full profile scared off t...16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
...ur: Award winning researcher reveals potential new role for Glivec in a soft tissue cancer Chairman: Professor Jaap Verweij (EORTC chairman of conference scientific committee) together with scientific committee co-chairmen Dr Janet Dancey (NCI) and Dr Eric K Rowinsky (AACR) NB: any reports involving th...$7.5 Million grant to Yale researchers for role of viruses in cancer
...ale School of Medicine to continue studies on the role of viruses and mutant cellular proteins in tumorig...try , also works on herpesviruses, focusing on the role of small viral RNAs in the induction and maintenance of tumors. Many RNAs that she studies were firs...The book opens on the first tree genome
...waste sites. Just as DOE earlier played a leading role in mapping the human genome and making possible ad...n. Ghent University (Belgium) played an increasing role in annotating the sequence that has been generated. With a genome consisting of more than 480 millio...NSF awards 22 new projects for plant genome research
...the inner workings of plants' genes as well as the role genetics plays in plant development, metal toleran...unction of maize centromeres, which play a central role in cell division and ensure that the newly divided cells each receive a set of chromosomes. A gro...UAF scientists discover new marine habitat in Alaska
... more of these beds and learn precisely what their role in the Alaska marine ecosystem is," said Konar. Mike Foster, professor emeritus at Moss Landing Marine Laboratory in California, has studied the global distribution of rhodoliths, and is the author of numerous scientific papers on the subject. He...Scientists explore genome of methane-breathing microbe
...biotech workhorse. Methanotrophs play an important role in the global energy cycle because they consume me...y could possibly be harnessed to play an important role in efforts to reduce methane emissions that are generated by biological sources such as ruminants an...Research suggests new avenue for stopping, preventing colon cancer
...The receptor, called PPARdelta, plays an important role in development, wound healing and fat metabolism. ...-like substances called prostaglandins that play a role in a wide variety of physiological functions. One of them, prostaglandin E2 (PGE2), has been specifi...Prion propagation: Avoiding the toxic oligomer
... near NM fiber ends. To investigate the role of oligomers in NM amyloid formation and growth, the researchers explored the relationship between monomer concentration and polymerization progress. Initially, fiber growth rate was tied to the concentration of NM monomers; but as concentrations inc...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...roinflammatory protein initially thought to play a role in the death of cancer cells. Investigators first ...o reduce tumor growth by killing cancer cells. The role of TRAIL was further illustrated in additional experiments where a neutralizing anti-TRAIL antibody ...Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
... clinical observations suggest it plays a critical role in brain function. Human chromosome-5 truncations that disrupt the function of the d-catenin gene correlate with the severity of mental retardation in Cri-du-Chat Syndrome; in addition, d-catenin is known to interact with Presenilin 1, the protein mo...Amyloid fibers sprout one step at a time
...e formation. But why such oligomers form and what role they play in making amyloid plaques was unknown. Weissman and his colleagues sought to understand the dynamics of how the amyloid puzzle pieces assemble themselves. They analyzed the timing of the yeast prion protein assembly, and how that varied wi...Brown ecologist garners major National Science Foundation grant
... by a single gene, allowing them to understand the role each variation plays in reproduction. Based on all this data, researchers will create computer models to predict when plants will flower and which will thrive in certain regions. Then, with the help of students sent for training in seven leading Euro...US investment firm gives away Rhode Island-sized lands in Chile
...le. "This announcement underscores the important role the private sector can, and must, play in the efforts to save wildlife and conserve wild lands," said Dr. Steven Sanderson, WCS President and CEO. "Goldman Sachs, the Goldman Sachs Charitable Fund, WCS and the people of Chile will be pioneering a new...Joslin researchers clarify mechanisms for beta-cell formation
...s--suggesting that PDX-1 likely plays an important role in regulating this growth. The results were published in the September 2004 issue of The Journal of Clinical Investigation. The research was funded by the National Institutes of Health, the Juvenile Diabetes Research Foundation Center for Islet T...JCI table of contents September 15, 2004
...icated in the development of atherosclerosis. The role of prostanoids in inflammation is well known, base...rosclerosis remain ill-defined. To investigate the role of each of these prostanoids in atherosclerosis, Shuh Narumiya and colleagues, of Kyoto University F...New fruitfly model of diabetes has future implications for pancreatic cell transplantation
...brain of the fly make insulin, which parallels the role of beta cells in humans. Now, in the September 16 issue of Nature, the researchers describe cells that produce a glucagon-like hormone, which are akin to alpha cells in mammals. These two cell types within the pancreatic islets are the main cellular ...