Human chromosome 5 final sequence analysis released to public
...the next generation. So far, nobody has shown what role the conserved regions play. "What this says is that we don't know as much about this conserved stuff as we think we do," Schmutz said. Hidden in the chromosome 5 sequence are clues to how humans evolved after branching away from chimpanzees. On aver...Picking prostanoids to provide protection
...icated in the development of atherosclerosis. The role of prostanoids in inflammation is well known, base...rosclerosis remain ill-defined. To investigate the role of each of these prostanoids in atherosclerosis, Shuh Narumiya and colleagues, of Kyoto University F...Protein is key to fatal disorder and normal cell function
...generative disorder of childhood, also plays a key role in normal cell function, Duke University Medical C...ase provide a unique opportunity to understand the role of proteins, like cln3, that are vital for normal cell function," said Rose-Mary Boustany, M.D., a p...A liking for sweets, combined with novelty seeking, may predict alcoholism
... that he and his colleagues decided to examine the role of novelty seeking in the equation because previous research has strongly implicated the presence of various elements of behavioral undercontrol a personality trait that reflects an individuals inability or unwillingness to inhibit behavioral respon...Genetically modified bacterium as remedy for intestinal diseases
... (TFF) into the Lactococcus. TFF play an important role in the protection and healing of the epithelium - ...f the stomach- intestinal system. They also play a role in the construction of the stomach-intestinal tract. This structural function ensures that TFF never...Protein is key for digestive function of the pancreas
...lead to pancreatic disease. While the most famous role of the pancreas is the production of hormones like..."These results suggest that VAMP8 plays a definite role in regulated enzyme secretion in pancreatic acinar cells," writes Dr. Hong. The researchers went o...IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth
...nt tissue. Relatively recently, a novel pathogenic role of angiogenesis has been established for such chronic inflammatory diseases as rheumatoid arthritis, psoriasis and atherosclerosis. As a result, suppressing neoangiogenesis is being investigated as a therapeutic approach for not only cancer, but als...... somitogenic cells by electroporation to study the role of a group of molecules known as Rho-family small ... Rho, Rac and Cdc42, is known to play an important role in the dynamic organization of the cytoskeleton, the framework of elements that determines many aspe...Molecule awakens and maintains neural connections
...y in the mature brain as well, where it may play a role in memory formation. The researchers published th... the fruit fly Drosophila that appears to play a role in regulating dendrite growth, or "arborization." In comparing the fruit fly gene with databases of ...Researchers identify distinctive signature for metastatic prostate cancer
... extend understanding of the Hedgehog pathway to a role in prostate cancer, which is a major form of cance..." said Beachy. "This finding led us to explore the role that the Hedgehog pathway might play in the function of normal progenitor cells." To study the rela...Sugar-coated sea urchin eggs could have sweet implications for human fertility
...ins are much better understood than sugars, so the role of the proteins in sperm can be studied relatively easily. Figuring out exactly how the complex sugars work will take more research, but developing such understanding, she said, could lead to solutions for human reproductive problems, including new a...Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets
...scovery of the exact structure of the tail and its role in cell replication holds promise that researchers...nt study shows that the tail of E2 plays a crucial role in a series of hand-offs in which NEDD8 passes from one enzyme to another. First, E2's tail helps E2...Researchers report new gene test for isolated cleft lip and palate
... results show that a specific gene plays a crucial role in the development of isolated cleft lip and palat...hich encodes a specific protein that plays a vital role in the normal formation of the lips, palate, skin and genitalia during the early stages of developme...Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
...nd platelet-aggregating factor (PAF). Due to their role in IBD, eicosanoid suppression has been considered for treatment. However, inhibition of one production pathway (say, COX) diverts the AA to the other (LOX), often exacerbating the condition. So they hypothesized that inclusive control of lipid media...New treatment for fibromyalgia
...micals key to mood and widely recognized for their role in depression. Not all patients with fibromyalgia, however, have depression or respond to antidepressants. Treatment studies of the other types of antidepressant drugs, including selective serotonin uptake inhibitors and tricyclic agents, have had mi...The impact of genetic variations on the treatment of early rheumatoid arthritis
... TNF, one of the body's chemical messengers with a role in regulating the inflammation. Although MTX and TNF blockers work well in the treatment of RA, they vary widely with regard to effectiveness and side effects, and there are currently no markers to predict response to particular drugs. ...New research suggests early diet may play key role in protecting against childhood leukaemia
... and lifestyle factors are thought to play a major role in the rising incidence. If this is the case, it s..."These findings are consistent with the protective role of fruits and vegetables observed in adult cancers." The association is thought to be due to the hi...Charting the future in prostate cancer care: A call to action
...he Prostate Cancer Foundation has played a pivotal role in supporting and funding R&D breakthroughs to defeat this disease. The timing is becoming ever more critical. As the baby boomer men reach the target age for prostate cancer, beginning at age 50, this disease will become the cancer with the greates...Berkeley Lab soil scientist Margaret Torn receives Presidential Early Career Award
...ion, one of the questions she is addressing -- the role of feedback mechanisms -- lies at the heart of how we can accurately predict climate change." Of her research, Torn says, "Most important, I am working to characterize the feedbacks between climate change and ecosystems -- as sources and sinks of gr...Missing genes may help explain why plague bacteria are so deadly
...ly expanded in Y. pestis, delineating the probable role of IS expansion in the elimination and modification of preexisting gene expression pathways." Sequencing of the Y. pseudotuberculosis genome was part of a "Bio-foundation Initiative" funded by the U.S. Department of Energy's Chemical and Biological N...