JCI table of contents, 2 August, 2004
... and targeting of these bone-marrow cells and what roles they play in promoting or inhibiting repair. Elizabeth Nabel and colleagues from the National Heart, Lung and Blood Institute at the NIH, theorized that factors important for cell cycle might be involved in this mechanism as they are important for s......of which (alpha, beta, and delta) have established roles in promoting adipogenesis (fat cell differentiation). The researchers were specifically interested in determining the physiological impact of replacing the C/EBPalpha gene with the C/EBPbeta gene. "No doubt, C/EBPalpha is very important for life as ...A changing landscape may have dire implications for birds
...s," says Lepczyk, who led a team that examined the roles of land cover and housing density on 137 species of birds, native and exotic. Of those, 37 species were affected negatively by humans, while 13 species had positive relationships and 23 species exhibited a mix of adverse effects and benefits from hum...New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
... study also provides clues to explore the possible roles of carbohydrate-mediated receptor-ligand interactions in SARS-CoV infection, especially in determining host-range and tissue-tropic characteristics of the virus. They urge collaborative efforts to elucidate the structure of sugar chains that are resp...APS/IUPS launch PHYSIOLOGY bimonthly
...orking to understand how these molecules work, the roles they play, and how changes in these molecules affect the function of everything from individual cells to the whole organism," Boron said. Physiology designed to appeal to broader audience The inaugural August issue of Physiology is going live with ...UNC researchers awarded $8.65 million from National Institute on Aging
...expression of myriad genes that may play important roles in vascular aging. "We will collaborate in developing animal models that have defects in these pathways or defects in multiple pathways. This will help us get to the individual contribution of each pathway to the process of vascular aging," ...Researchers review evolutionary history of modern algae
...nt of the oxygen production. Despite the important roles of modern phytoplankton, their evolutionary origins and rise to prominence in today's oceans was an unresolved question in marine science. In the first study that looks at phytoplankton from combined perspectives of biology, chemistry and geology,...NIH renews funding for continued Rb2 tumor suppressing gene research at Temple
...ti-functional, with the discovery of its important roles in cell differentiation, HIV transcription and tumorigenesis. The author of more than 200 published articles, Giordano has done pioneering work in the fields of cell cycle, gene therapy and the genetics of cancer, paving the way to the development o...Scientists pinpoint molecules that generate synapses
...re very similar in structure, and may play similar roles in other areas of the nervous system....How wounds heal Clues from flies
...l stage of the fruitfly, the authors looked at the roles of specific genes to shed light on the cellular events of healing. Indeed, they found that one particular cell signaling pathway was activated during the peak hours of wound healing. Inhibiting the pathway in fly mutants had dramatic effects on the w...NRH1 and Wnt signaling come together in convergent extension
...otrophins, which led them to seek other biological roles for the protein. Experiments in which NRH1 was ove...nteracts with the cytoskeleton and plays important roles in the dynamics of cell morphology and motility. Overexpression and loss-of-function of NRH1 in the ...Significant strides in small regulatory RNA research in plants
...d animals. miRNAs have been found to play specific roles in plant development, including the regulation of flowering time and floral organ identity, and leaf polarity and morphology. Researchers William J. Lucas at the University of California, Davis, and Tony J. Lough at AgriGenesis Biosciences...Scientists discover key step in the development of nerve cells controlling autonomic functions
... time that similar mechanisms involving Runx1 play roles in motor nerve cell and blood cell development and...ronto. "We believe that Runx1 plays very important roles in promoting the development and survival of those specific hindbrain motor nerve cells", said Dr. S...UCSD biologists discover cell's defense mechanism against class of disease-causing bacterial toxins
... two that were known to play important and general roles in immunity in humans. However, these genes had never been shown to be important for protecting against this class of bacterial toxin. Aroian and Huffman further discovered that these two genes, SEK1 and KGB1, controlled two "pathways" of biochemica......way (see Figure below) and are known to play major roles in the plants' wound recognition. However, their defensive function has only been tested in laboratory studies. When planted into native habitats, LOX3-deficient plants were more vulnerable to N. attenuata's adapted herbivores but also attracted two ...JCI table of contents, 1 July 2004
...n. In doing so, they were able to dissect specific roles for different members of the PPAR gene family in different tissues. Specifically, their data here show a direct role for PPAR_lpha in the metabolism of glycerol metabolism in the liver, while another member of the PPAR gene family, PPAR_amma_ control......portant for gene expression, and they play crucial roles in the ability of innate immune cells to make lethal responses to bacterial infections, of skin cells to cover wounds during the healing process, of vascular cells to make new blood vessels, of cancer cells to metastasize, and of neurons to develop a...New insight into cancer metastasis
...e other regulators undoubtedly will play important roles in other types of human metastatic cancer." ...Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
...e scientists to gain a better understanding of the roles of miRNAs in cancer and provide targets for future...explains that miRNAs are thought to play important roles in regulating gene expression during development and cell differentiation. MiRNAs inhibit the functi...New study confirms process leading to disorder causing male characteristics in women
...opulations. Past research emphasized the relative roles of neuroendocrine abnormalities leading to persistent and excessive secretion of luteinizing hormones (LH), one of two glycoprotein hormones that stimulate the final ripening of the follicles and the secretion of progesterone; and the ovarian actions...