Other highlights in the March 3 issue of JNCI
...Taiwan University, and colleagues investigated the roles of CTGF and its possible downstream effector collapsin response mediator protein 1 (CRMP-1) in invasion and metastasis in cells from human lung adenocarcinoma, a cancer that is known to metastasize quickly. They conclude that CTGF inhibits metastasis...JCI table of contents, March 1 2004
...formation. Further experiments elucidated critical roles for both the Smad and p38 downstream signaling pat...ytes for cartilage reconstruction. TITLE: Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts AUTH......archers an unprecedented glimpse at the regulatory roles and mechanisms behind RNA interference. Hutvagner and colleagues constructed an oligonucleotide inhibitor based on the sequence of a microRNA called let-7, which blocks the production of the protein Lin-41 and is important for proper developmental t...Fuel-cell microbes' double duty: treat water, make energy
...es, countless and variousbacteria play distinctive roles in the breakdown of thewastewater and creation of electricity."This is a whole community reaction," said Logan. "We're justbeginning to appreciate and understand the complex bacterialcommunity needed to generate electricity from wastewater."...Food tastes stronger when you're hungry
...pects that this difference is due to the different roles that the tastes play: "While sweet and salty tastes are indicators of edible substances and trigger consumption, a bitter taste indicates a substance which is not suitable for consumption and should be rejected." The importance of recognising bitter...Experimental Biology 2004 - Translating the Genome
...rotection programs, with a special emphasis on the roles of Institutional Review Boards. Special poster sessions will focus on new methods and materials for teaching, including computers, models and simulations. Scientists and postdoctoral and graduate students can attend workshops on preparing res...Oxidation processes basis of interdisciplinary research, graduate training
...dicine are also interested in nutrition and in the roles of free radicals in disease, and will help the MILES researchers understand the biomedical implications and evaluate the success of their discoveries with animal models. Janet Rankin and Mike Houston, professors of human nutrition, foods, and exerci...Pioneer in the genetics of programmed cell death honored
... the last two years, Korsmeyer identified distinct roles for BCL-2 members. His rigorous analysis of these novel proteins established a mammalian apoptotic pathway and placed multiple landmarks along its course. A native of Beardstown, Ill., Korsmeyer received both his undergraduate and medical degrees...Computer scientists develop tool for mining genomic data
...rmed in wet-lab experiments, suggesting regulatory roles for previously uncharacterized proteins. ''The creativity and computer science perspective brought to these problems by Koller and her collaborators provide a tremendous boost to biology,'' says Matthew Scott, a developmental biologist at Stanford an...Passwords to guard entry aren't enough to protect complex data
...istrator in a traditional system defines different roles for different users, and those roles define the type of access allowed. The good news about traditional systems is that bad guys must emp...Molecular mechanisms that trigger flowering in spring
... isolation of genes and proteins that play central roles in this process. In the recent issue of Science ( Science ,13th February 2004) a group at the Max Planck Institute for Zchtungsforschung in Cologne describes how a molecular circuit around the protein CONSTANS induces flowering. This protein accumu...Asia's biodiversity vanishing into the marketplace
...nimal populations. "As animals that perform vital roles in the forest as predators, pollinators and seed dispersers disappear, other species will also go." In last 40 years, 12 species of large animals have become extinct or virtually extinct in Vietnam due mainly to hunting and wildlife trade. Even pro...Researchers adapt RNA interference to study gene function on a large scale
... already applying the methodology to determine the roles of genes in many other aspects of signal transduction and cell biology. We are using the technique to study gene function in pathways involved in communication between cells and those associated with cancer; as well as aspects of cell biology such as...Scientists' findings may lead to better understanding of how that sleep develops, matures
...EEG markers may reflect their different functional roles in the sleep process during infancy....Reward mechanism involved in addiction likely regulates pair bonds between monogamous animals
...anxiety in mice; Vasopressin and oxytocin play key roles in the formation of social attachments between animals. Increasing the amount of vasopressin receptors in the brain using gene transfer techniques can increase pair-bonding behavior in monogamous male prairie voles. ...JCI Table of Contents, January 15 2004
...://www.the-jci.org/press/16269.pdf Independent roles for insulin in metabolism and cellular growth In...ormone (ACTH) release. To further investigate the roles of V1b, Gozoh Tsujimoto and colleagues from Kyoto University, Japan, created mice lacking the V1b re...New study finds evolutionary diversification in Hawaiian spiders
...n the island's history. She studied the ecological roles of different spiders, recording their behavior patterns and noting which insects they fed upon. She also used the DNA of the spiders to create a family tree charting the evolutionary history of the Tetragnatha species in Hawaii. The spiders can b...OHSU-led research examines role of copper, iron in diseases
...sms control metal ion transition in cells, and the roles that metals play on cellular regulation and cell-t...o generate vascular systems has been linked to the roles of various metals complexes," Blackburn explained. "So there are growing numbers of diseases that ar...RNA lariat may tie up loose ends to decades-old mystery of retrovirus life cycle
... in healthy cells and play previously unrecognized roles in cellular processes such as gene activation. "The work of Menees and his collaborators fills a real voidin our understanding of how retroviruses propagate and howgenetic information is faithfully copied," said Patrick Dennis, program director for m...... Lifestyle and environmental factors also play key roles in a person's risk for the disease. But the Alox15 study, Klein said, "could point to new therapies, a new approach" for treating the disease. "It points the way toward potent, useful human therapies," said Orwoll, director of the Bone and Mineral Re...