Changes in shape of single protein plays key role in the spread of cancer cells
...ulin is a critical protein that performs different roles in the body," Boise said. "It is a master conductor of much of the cell's life, changing its shape to conduct the cell's business according to the cell's immediate needs." Other authors of the study include Robert A. Borgon and Christina L. Rush (St....JCI table of contents, January 2, 2004
...******************* ONLINE FIRST ARTICLE Distinct roles for VEGF isoforms in bone development During bone...erapy in humans remain unresolved. TITLE: Critical roles of TRAIL in hepatic cell death and hepatic inflammation AUTHOR CONTACT: Youhai Chen University of Pe...New roles for protein modifications in cell migration
...ich help to build skin and soft tissue), and their roles in development and differentiation are the focus o...ein chain, a post-translational modification whose roles are incompletely understood, but which is thought to serve a regulatory function in some signaling m...Quark Biotech generates a cholesterol-free mouse
...block of cells and their membranes and plays major roles in signal transduction. The paper entitled "Generation of Viable Cholesterol-Free Mice," appears in Science , December 19, 2003 (Vol. 302, Page 2087). "We were surprised by the fact that a mouse lacking cholesterol can survive and develop into adult...New understanding of insulin's complexities needed to conquer diabetes
... could start to explain type 2 diabetes." The dual roles of insulin pathways in the regulation, growth and survival of insulin-secreting beta cells creates a surprisingly fragile "closed loop system," said White. It seems absolutely the wrong way for nature to build such a critical system," he said. "The w...Squirrel invasion sows seeds of change for future forests
...and seeds in the same way, and they play different roles in the forest community, Goheen said. Gray squirrels use what ecologists call "scatter hoarding," in which they bury single nuts, such as acorns and walnuts, in numerous locations. Being a bit squirrely, gray squirrels seldom remember where they bury...Global wetlands surveyed from space
...d, but scientific understanding of their important roles in terms of biology and the water cycle has grown, spurring international efforts to preserve them. On 20 November ESA formally began a project to map wetlands from space, providing data on around 50 sites in 21 countries worldwide. In 1971 an inter...Researchers show absence of key oxygen-sensing molecule leads to developmental defects
...des turning on specific genes that have protective roles to alleviate the detrimental effects of reduced oxygen in the cells. It likewise has an adaptive response to oxidative stress that involves increasing the expression of genes whose function is to eliminate oxygen radicals and their potentially harmfu...Philippines: Park expansion creates nation's largest contiguous protected area
...cosystem Partnership Fund (CEPF) also played major roles in making the Peablanca expansion a reality. The Sierra Madre Biodiversity Corridor is a patchwork of protected areas strung along the 1.7-million-hectare mountain range. The Sierra Madre's forests are home to about 45 percent of all the country's pl...Investigational cancer drug prevents abnormal brain growth, reverses seizures in lab mice
...portant because they show that mTor plays multiple roles in the brain from regulating the size of individual cells to more complex functions of neurons, such as signaling, according to Suzanne Baker, Ph.D., associate member of the St. Jude Developmental Neurobiology department. Baker is senior author of a...Ten-year study leads researchers to psoriasis genes
...tics on Nov. 9. "Now we can look at the functional roles of these genes -- how they normally keep the skin and the immune system from damaging healthy tissue with their defensive mechanisms," Bowcock explains. "These results are going to help us find answers for some very important questions, including how...Activity detailed for sirtuins, involved in metabolism, aging, gene expression
... family of enzymes known as sirtuins play critical roles in a wide array of vital life processes, including...y and is likely responsible for the specificity of roles seen among the various sirtuins each different sirtuin binds to a different target and carries out ...High school students to analyze plant genes for national project
...ool science labs to provide answers concerning the roles played by the 25,500 genes of the "white mouse" of the plant world, Arabidopsis thaliana. "The students will be doing a first-pass analysis," said Erin Dolan, outreach director for Virginia Tech's Fralin Biotechnology Center and the principal investi...Wolves are rebalancing Yellowstone ecosystem
...uding two species of cottonwoods and the myriad of roles they play in erosion control, stream health, and nurturing diverse plant and animal life. The findings of these studies were recently published in Ecological Applications, a journal of the Ecological Society of America, and the journal Forest Ecolog...Young cancer researchers honored
...termined the structures of many proteins that play roles in the formation of cancer. The prize, named after Paul A. Marks, MD, President Emeritus of MSKCC, recognizes significant contributions to the basic understanding and treatment of cancer by scientists no more than 45 years old at the time they are no...Embryonic pathway critical to growth of digestive tract tumors
...rs, notes Berman. "Because of Hedgehog's important roles in these tissues during development, we hypothesized that 'reactivation' of the pathway occurs in adult life during cancer development in these organs," adds Maitra, whose procedure for obtaining fresh samples from surgically removed tumors provided ...JCI table of contents, 15 October, 2003
...ession of inflammatory genes that play detrimental roles in atherosclerosis. On the other hand, NF-kappaB i...omprises multifunctional cells that play important roles in maintaining blood pressure, clotting, the immune response, and inflammation. Following injury or ...Scientific study of twins shows forgiveness has genetic component
.... To illustrate how twin studies can elucidate the roles of genetic and social factors in human development. 2. To provide the first estimates of the contributions, from the North Carolina juvenile twin study, of genetic and environmental influences to the development of forgiveness in adolescence. 3. To s...MicroRNA targets: How big is the iceberg?
...it has become clear that RNAs play far more active roles in most if not all plant and animal species. We know that small RNAs that do not encode proteins themselves can regulate messenger RNA molecules that do. They bind to their specific targets, which are then degraded rather than translated into protei...New gene necessary for plant growth and development discovered
...dampens the effect of auxin. Auxin plays important roles in the development of roots, stems and leaves, but...ism, preventing researchers from discovering other roles for that gene later in development. Since chemical genetics is reversible, by simply stopping the ap...