UNC studies identify key genes involved in blood vessel development
...Chapel Hill has identified two genes that play key roles in regulating blood vessel development. The research appears in two reports published in the Aug. 15 issue of Molecular and Cellular Biology, a professional journal. Dr. Cam Patterson, professor of medicine and director of the Carolina Cardiovascular...From studies of a rare human mutation to new approaches to herbicides or antibiotics
...from bacteria through plants and humans. Important roles for PBGS include formation of chlorophyll in plants and the heme component of hemoglobin, the protein that carries oxygen in the blood. A September 1999 report of a routine screen of newborn infants for metabolic defects identified a new mutation in...Researchers identify protein modules that 'read' distinct gene 'silencing codes'
..." says Allis. Both HP1 and Polycomb play important roles in silencing certain genes crucial for proper development of embryos in a range of species from fruit flies to humans. Loss of HP1 correlates with metastasis in human breast cancer cells, and mutations in Polycomb proteins have been linked to cancers...First structure of transporter enzyme family is solved
...r explains:"Membrane transport proteins play major roles in depression, stroke and diabetes. Unravelling their structure is critical not only for understanding how we function, but also to improve drug design. Indeed, two of the most widely prescribed drugs in the world, Prozac and Prilosec, act through th...New compound class found to trigger changes in cell garbage can
...for use in healing wounds because of its multiple roles as an agent that stimulates vessel growth, inhibits inflammatory responses and kills bacteria. Coauthors include Mark Post, visiting associate professor of medicine at DMS, as well as M. Maria Gaczynska and Pawel A. Osmulski, of the University of T...New approach to gene knockouts reveals the 'master planners' of the skeleton
...nd Hox11 establish that the genes play important roles in orchestrating the construction of the ribs, spi...ion to more closely discern the true developmental roles of specific members of the Hox gene families. The 13 sets of Hox genes, each with multiple membe...Protein holds promise as new diabetes drug target
... beta cell or liver, to understand tissue-specific roles and regulation. "Studies performed at Vanderbilt were essential for demonstrating the importance of this enzyme," Magnuson said. After the glucokinase gene was cloned, other investigators identified mutations in the human gene. Mutations that cause ...Penn researchers identify secondary pathway for survival of cancer cells
... Akt pathway is well studied because it plays many roles in cancer progression, including a key role in cancer cell survival. Both Pim-2 and Akt survival pathways were found to operate independently; Pim-2 was not activated by any of the Akt pathway regulating enzymes PI3K, HSP-90 and TOR. While Akt in...A sex-specific gene for depression
...f large numbers of other genes that play important roles in the brain and the rest of the body as well. The widespread importance of CREB as a genetic regulator throughout the body suggests that the newly identified CREB1 variants may influence the development of additional psychiatric disorders related t...New target for skin cancer confirmed
...micals in the skin, and biochemicals that play key roles in carcinogenesis make potential therapeutic targets. Many human cancers show elevated activity in some form of JNK enzyme, and the enzyme is also activated by sunlight, Dong said. "Even if one goes into the sun for a few minutes, the activity of JNK...'Unzipping' double helix to study protein-DNA interaction
...rnell University biophysicists are discovering the roles of DNA-binding proteins in much the same way an impatient person frees a stuck zipper. Not exactly brute force -- but rather carefully metered dynamic force -- is the key to pulling apart two strands of the DNA "zipper" and popping loose restriction ...New science at K-State attracts $4.2 million from National Science Foundation
...st two of the genome-world's superstars have major roles in ecological genomics research as it unfolds: the... will focus on functions of lipids in animals, the roles of lipids in diseases like multiple sclerosis and globoid cell leukodystrophy, and cell growth arres...Abnormal plant shows scientists path to plant, animal development
...ulated genes. So, we're finding similar regulatory roles for both human and plant proteins." Ogas and his team found the embryo-promoting genes by studying a strain of Arabidopsis in which PKL is abnormal, or mutated. The mutated gene, designated as lowercase pkl, was unable to repress the embryogenesis ge...Pitt researchers find genes for depression; Play role in mood disorders, shorter lifespan
...ion of programs of other genes that play important roles in the brain and the rest of the body. The widespread importance of CREB as a genetic regulator may influence the development of additional psychiatric disorders related to depression, such as alcoholism and other addictions, as well as medical condi...Mouse model of schizophrenia could speed identification of new antipsychotic drugs
...eurin is an enzymatic switch that plays regulatory roles in both the immune system and the brain. Until a brain-specific knockout mouse was developed in Tonegawa's laboratory, it had not been possible to pinpoint the enzyme's function in the brain. In earlier studies, Tonegawa and his colleagues found that...Chemical Heritage Foundation and BIO give Biotechnology Heritage Award to William Rutter
...Genomics, received the award in 2001 for their key roles in the sequencing of the human genome. About William J. Rutter Rutter is the cofounder of Chiron Corporation and served as chairman of its Board of Directors from Chiron's inception in 1981 until 1999. In 1969 Rutter joined the faculty of UCSF as H...Development of prostate drug based on UT Southwestern research
...researchers at UT Southwestern have played pivotal roles in various phases of this work." Dr. Roehrborn, who has been involved in the testing of Proscar, wrote a paper last fall about dutasteride, a drug developed by GlaxoSmithKline that is also designed to replicate the effects of 5-alpha reductase defici......ful 18" x 24" poster that vividly details the many roles water plays in our lives and describes ways that every citizen can use water wisely. Intended for educators, policy makers, and the general public, Water and the Environment is written in non-technical language, contains many photographs and graphic...Finished Y-chromosome sequence reveals a genomic 'crystal palace'
...one copy in males. So, maybe we should rethink the roles of the second sex chromosomes in these often dramatic differences in disease susceptibility between males and females."......sodilatation and consequent mucosal edema play key roles in development of the observed nasal congestion given that both the histamine-induced congestion in nonsensitized dogs and the ragweed-induced changes in sensitized dogs were susceptible to the treatment with -adrenomimetics. Conclusions The measur...