Molecular structure suggests how a gene can "jump"
...DS, researchers in the pharmaceutical industry are screening compounds that can inhibit HIV-1 integrase, according to Rayment and Reznikoff. Because HIV-1 integrase and Tn5 transposase have similar structures, the Wisconsin scientists believe they now have a model system that can help scientists identify or de...AAAS seeks entries for online category in Science Journalism Awards
...e grounded in science and technology. Independent screening and judging committees comprised of scientists and science journalists select the winning entries, which are published each year and used as teaching tools in science writing programs at universities and colleges throughout the country. AAAS is the w...BRCA1 cancer gene plays pivotal role in DNA control complex
...eins in the complex may themselves prove useful as screening tools for predisposition to breast and ovarian cancers." DNA, in the form of a double helix, is a long molecular strand of genetic instructions stored in the nucleus of every cell. To keep order, nature has developed a method of tightly packaging the...Chemists report new approach to synthetic fragments of medically important Heparin
...ble to obtain Heparin fragments to perform a quick screening to determine interactions with biologically and medically important proteins. At present, scientists know that Heparin is involved with biological processes, but they aren't quite sure how all the processes work, and they are quite certain that curre...Gene for Mucolipidosis IV discovered
...heir findings will now enable effective population screening for detecting carriers, and accurate prenatal testing for families at risk. The discovery may also eventually lead to new patient therapies.......andardized measurement of female sexuality. After screening and a four-week base-line period, the women participated in three consecutive 12-week treatment periods, receiving two abdominal patches that were changed twice a week. The sexual functioning questionnaire and an assessment of psychological well-bein...Tiny polymer patterns might act as glue in 'biochips'
... in the laboratory for speedy chemical and genetic screening of blood and other biological materials; to instantly analyze food products for contamination; and in future implantable medical devices that continuously monitor glucose in a diabetic person's blood and then automatically administer insulin. The b......t mutant kinases in animals will prove useful for screening such drugs. "In our experiments, we essentially identify potential drugs to inhibit kinases as we are proceeding in our basic research. Drug companies can see the effect of specific inhibitors of a single kinase without having to launch a more g...Scientists spot way around cystic fibrosis cells' poor performance, way to improve drug testing
...ells, the new work should quickly lead to improved screening of CF therapies, Li says. The traditional way to spot a useful drug, for example, has been a painstaking method isolating cell membranes and making measurements of minuscule changes in current. "But now that we know that dimers --the double CFTR mo......vant validated drug targets moving in to or beyond screening in first two years of collaboration CAMBRIDG...levant validated drug targets into high-throughput screening or lead identification in the first two years of their five-year research alliance. The alliance ac...Procter & Gamble donates proprietary "super aspirin" technology to Vanderbilt University
...," Rothenberg said. "We will conduct pre-clinical screening of a large number of drug combinations, including the P&G COX-2 Inhibitor Technology compounds, to help identify leads for cancer treatment." In addition to cancer research, Vanderbilt intends to research COX-2 Inhibitor Technology's potential for Al...Novel blood marker shown to predict the incidence and severity of coronary artery disease
...easures of CAD and may form the basis for a simple screening test to accurately determine the incidence and severity of cardiac ischemia," said Roger A. Sabbadini, Ph.D., professor of biology at San Diego State University and president of Medlyte Diagnostics, Inc. The research was supported by Medlyte Diagno......ncy, and that clinicians should consider routinely screening older women and recommending calcium and vitamin D supplementation for those who are deficient as an inexpensive and effective intervention....One in three physicians unlikely to get routine medical care
...s that physicians didn't take advantage of mainly screening for colon cancer also are practiced less among the general population," says Michael J. Klag, M.D., M.P.H., interim chairman for the Department of Medicine at Hopkins and director of the study. "Still, because physicians' health beliefs and practic...Researchers find candidate gene for premature menopause
...in a family with a history of premature menopause, screening younger women members would provide valuable information to help them plan their families." The researchers are expanding their investigations to include more samples, to look at other similar genes in the inhibin pathway and at other reproductive di...Can a vitamin a day help keep heart disease away?
...f B12 per day for all at risk of heart disease; or screening all at-risk people and giving vitamins to those wi...und that despite the up-front blood test cost, the screening approach would cost up to 60 percent less in the long run, since vitamins would be targeted at those...Infections may trigger autoimmunity via rare, but normal process
...apparently evades detection by the immune system's screening against cells that attack self. Then, under certai...B cells able to react with self and assumed that a screening process of some kind must exist to eliminate the self-reactive cells. The new work from the Wistar s...With HIV rising, UMBI tailors vaccine for Nigeria
...ograms--advertisements, condom distribution, blood screening guidelines, integration of HIV programs in the schools, etc. But complex programs such as vaccine testing will require comprehensive planning and coordination....Idun develops new drug screen for treatments of stroke, heart attack, and cancer
...ey apoptosis reaction adaptable to high throughput screening KEYSTONE, Colorado, January 22, 2001 - Idun Phar...ne discovery, functional genomics, high throughput screening (HTS), biochemical validation, structural modeling, and targeted drug development and apply them to ......tein chip technology is useful for high throughput screening of protein biochemical activity," Snyder said. "Our method takes advantage of genomics and all of the targets in one simple experiment."...