Molecular staples shape a cancer killer
...ncers. Walensky said he would not be surprised to see hydrocarbon stapling of alpha-helices applied to control many interactions between proteins. "The alpha-helix plays a pivotal role in many biological interactions," said Walensky. "So if we could target protein-protein interactions at critical biolog...Computer models expose humans as main cause of caribou decline
... introduced different variables into the models to see what effect, if any, the changes had on the develo...ly after being cut. Research is being conducted to see if these measures lessen the impact on the caribou. However, whether these measures prove effective ...Men from early middle ages were nearly as tall as modern people
...ck in time and look at more diverse populations to see if this general relationship holds over 10,000 years," he said....Chernobyl study: Risk of thyroid cancer rises with radiation dose
... in children was practically nonexistent. Today we see dozens and dozens of cases a year in the regions c...tigate a larger population in a similar fashion to see if these findings can be replicated, Davis said.For his contributions to the field, earlier this yea...DHA-rich diet protects brain from Alzheimer's damage, UCLA study shows
...utschy. "These changes closely resembled those we see in the brains of people with Alzheimer's disease." Although the mice on the DHA-supplemented diet also carried the Alzheimer's genes, they still performed much better in memory testing than the mice in the first group. "After adjusting for all...Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
...fimbriae'. These appendages are very difficult to see using the available electron microscopy techniques, and were originally classified as non-fibre or 'afimbrial'. The new key piece of evidence emerged from some nifty protein engineering of the protein subunit, known as AfaE. These subunits make up th...Convulsions in worms mimic epileptic seizures
...y expressed in the nervous system, so we wanted to see if there was a way to use C. elegans to understand and simplify the complexities of brain disease." The team identified a mutation in the LIS1 gene that causes the encoded protein to be only one-fourth the length of the normal protein. The mutation ...Analysis of gene expression in lymphoid cells can determine lymphoma cancer
...very important player in specialized tissue, as we see in this study with lymphoid tissue."...Protein involved in childhood disorder linked to cancer
...e involved in DNA checkpoint responses. Curious to see if microcephalin is involved in these responses, Stern and Xu, along with Juhie Lee, M.D./Ph.D., engineered cells with reduced microcephalin. They found that when they damaged the DNA in these cells with radiation, the checkpoint response was impaire...Environmental costs of home construction lower with wise choice, reuse of building materials
...tarted by 15 universities and research institutes, see http://www.corrim.org/ . The $1 million effort was supported by those institutions, the United States Department of Agriculture Forest Service, U.S. Department of Energy and major wood-product manufacturers. A 12-page summary recently published in...Streptococcus infects humans by thwarting blood clotting
...mutate their streptokinase to keep up. So, you can see how one bacterial species and one host get locked in this evolutionary dance and would evolve apart from other host-bacterial pairs -- ending up with a multitude of variants of streptococci, one for each host. "This evolutionary mechanism probably fu...Strep disrupts blood clotting to infect humans
...d Hughes Medical Institute investigator. "You can see how one bacterial species and one host get locked in this evolutionary dance and would evolve apart from other host-bacterial pairs---ending up with a multitude of variants of streptococci, one for each host. "This evolutionary mechanism probably fun...New genetic research demonstrates possible cause of inherited form of Parkinson's disease
... mutant alpha-synuclein gene and it is exciting to see how this information can be used to possibly determine the cause of Parkinson's disease." Blockage Causes Neuron Death Neurons that release dopamine, the neurotransmitter that controls coordinated movement, slowly die in people with Pa...NJIT chemist speaks Aug. 25 about compound derived from pine tree
...sing non-toxic, cost-efficient methodologies. "We see them eventually providing one of the most useful tools for green chemistry," said Sanjay V. Malhotra, PhD, assistant professor of chemistry at NJIT. Malhotra is the principal investigator of a one-year study nearing completion this fall. A larger gr...Computer database being developed at Temple will allow for better inventory of chemicals
...le being moved. But you can query the database to see where these chemicals might be stored and how long... says Rappaport. With the database, youre able to see at a glance right from your computer what safety equipment is due for inspection or is out of compli...Trojan Horses, xenon imaging and remote controlled genes
... is actually getting inside of cells and tissue to see what is going on as it happens. At the University of Pennsylvania, researchers are caging molecules xenon, gene-blocking strands of antisense DNA and even therapeutics to facilitate their entry into cells and enable researchers to observe nature's...Two warbler species find the West isn't big enough for both of them
... of just two types of plumage, observers typically see a notable array of feathers. "Many of these are presumably the result of hybrid matings between the 'tough-guy' Townsend's and the females of the 'wimpy' hermit species," Butler said. The hybrid birds appear to carry androgen levels similar to Town...Decreasing toxins in brains of Alzheimer's patients keep cognitive deficits at bay
...mer oral medications alone. "We were very happy to see this amount of reduction," says Pratico, who adds that the research team predicted reductions only half that size. Additionally, the normal components of CSF like glucose and immunoglobulins did not change after the shunt was placed in patients. The ...Carnegie Mellon scientists reveal ways of studying, resolving PCB contamination in US rivers
... The following findings will be presented: Please see individual embargo days and times. ENVR 12. Microbial communities in two river sediments demonstrate distinct anaerobic PCB dechlorination patterns. (embargo 8:50 a.m. ET, Sunday, Aug. 22, Christine Wang, Department of Biological Sciences, presentin......eir activators to different DNA-binding domains to see if that affects their activity....