NIH funds new AIDS drug discovery research with $4.6 million
...e team to identify and isolate specific functional segments of RT for further structural work by Arnold and biochemical analysis by Hughes and Parniak. Jones' innovative creations will allow specific molecules to be tracked as they interact with RT, permitting structural and biochemical studies not otherwise...NIST genetics research lends a hand in World Trade Center IDs
...ped method using short tandem repeats (STRs)--tiny segments of DNA containing two to five base pairs (the nitrogen compounds whose unique pairings make up the genetic code of an individual). By contrast, a complete human genome contains some 3 billion base pairs. To perform the STR analysis, many copies are m...Scientists produce the script for life
... DNA microarray technology, which displays ordered segments of DNA and provides researchers with a compact format to quickly analyze how proteins interact with the DNA of an entire genome. Of the 141 transcription factors known for baker's yeast, Young and his colleagues observed that 106 bound to about 2,30...Transposable elements in malaria mosquito genome may offer a tool for control of disease spread
... set of genetic material including genes and other segments of DNA in an organism. More than a hundred researc...d in characterizing transposable elements (TEs) -- segments of nucleic acids, or genetic material, that move around the genome and have a significant impact on ...Mosquito genome sequence--Published in the journal Science
...hotgun" method, which involves randomly sequencing segments of DNA from all over the genome and then connecting the segments by matching their overlaps. The assembled genome sequence is 278 megabases long. (Each megabase equa...DNA separation by entropic force offers better resolution
...s in liquid, the effect results from the motion of segments in the chain molecule as they interact with the beginning of the barrier. The force is called "entropic" because the molecule moves out of the restricted space of the sieve into an open area where it can be more disordered. In the latest experiment,...One gene, two important proteins
...nt of the long STAT92E protein - the embryo's body segments disappeared. These experiments, reported in the current Genes and Development, demonstrate that this new, alternate STAT is indeed a negative regulator of STAT92E activity. In the same paper, they also showed that the ratio of the short to the long p...DNA evidence suggests 3 types of elephants roam Africa
... and nuclear microsatellite loci (short repetitive segments of DNA that show differences among populations and individuals) suggest the existence of "three recognizable taxa of African elephants," their results need to be confirmed before a formal taxonomic revision of the African elephants is proposed. That...Personal body part grown in a dish
...penises of several rabbits have been replaced with segments grown in a lab from their own cells. The animals were able to use the reconstructed organs to mate. The next step is to try to recreate the entire organ from scratch. The technique could make it possible to reconstruct the penises of men who have suf...Of mice and men: Deaf mouse leads scientists to new human hearing loss gene
... mouse study helped them zero in on it. Using DNA segments made by Kohrman's team to "search" for similar stretches of DNA in tissue samples from the families, the groups at Iowa and NIH checked for defects in the human TMIE gene. They found three mutations in a day and a half, then found two more -- each ca...HIV targets active genes in cells
... out where the viral DNA ended up. By matching DNA segments with the published human genome sequence, they found that that the viral DNA mostly ended up in areas of the chromosomes where there are human genes, rather than places in between. The researchers then asked, "What is it about these genes? Are they a...Three dimensional structure of a protein transport machine
... a secondary structure, which are 15 transmembrane segments in each monomer. At the dimer interface there is a cavity, which may be a doorway through which proteins are pushed by associated partner proteins. This structure is the first step on the way towards an in-depth understanding of this fundamental biol...Evolution of language: FOXP2 and human uniqueness in religious perspective
...differences in the informational sequencing in DNA segments can set one species qualitatively apart from another." Q: Are there any deep philosophical implications in this research? A: "The FOXP2 research might tempt us into a reductionistic thinking that tries to explain complex things only by breaking the...Emory School of Medicine teams with deCODE Genetics to study link between genes and disease
... disease gene research, in order to identify small segments of chromosomes shared by patients with a particular disease. Genotypes are compared between closely and distantly related disease sufferers. More detailed genotyping of these small regions enables the identification of particular genes or sections ...Jumping genes can knock out DNA; alter human genome
...chool report that, in cultured human cancer cells, segments of junk DNA called LINE-1 elements can delete DNA when they jump to a new location possibly knocking out genes or creating devastating mutations in the process. "The value of this study is the unexpected knowledge that LINE-1 elements have the poten...New insights into insect antimicrobials point the way to novel antibiotics
...ists at The Wistar Institute have identified which segments of the peptide are necessary for the killing of bacteria and which segments are involved in bacterial and mammalian cell entry. The Wistar scientists further confirmed that thi...Physical map of mouse genome now available
...nother way, as well. It was assembled using longer segments of DNA than those used to assemble the draft sequence. The long segments were grown, or cloned, in bacteria. Now that the mapping is complete, the bacteria containing these ...Genetic studies shed light on the malaria parasite's origins and drug resistance
...o expose the recent evolutionary history hidden in segments of the parasite genomes. "This showed very clearly that a large segment of a parasite chromosome had hitchhiked along with the key chloroquine resistance gene," says Dr. Wootton. "This is a hallmark, we think, of how chloroquine has exerted strong ...Parasite or partner? Study suggests new role for junk DNA
...2 issue of Nature Genetics, however, suggests that segments of junk DNA called LINE-1 elements deserve more re...1s are so ancient and because they sometimes carry segments of genes with them when they jump to a new location, Moran believes they have played an important ro......the set of all assembled contigs (contiguous small segments of the genome) of all sizes; 2) the set of individual sequences that were used to create those contigs; 3) a file containing the quality values (estimates of error rates) for each individual sequence; and 4) a set of 1,000-base pair regions centered ...