Enzyme's "Magic" May Hold Key to Anticancer and Antimicrobial Drugs
...ancer cells, which divide wildly, are more sensitive to drugs that target topoisomerases than normal, more slowly dividing cells, Dr. Wang said. Part of the power of drugs that target topoisomerases is that they complement drugs that attack different cellular targets, and so can......back as 600,000 years. In addition to using a more sensitive dating method, Ku believes he has reduced error by analyzing undisturbed limestone from the strata in which the bones were found instead of studying the fossils themselves, as previous investigators had done. According to Ku, there is evidence that r...Race Plus Roaches: A Breathtaking Link
...6.4 times more likely than a Caucasian child to be sensitive to allergens left behind by cockroach droppings an...t children in the most infested homes are the most sensitive to the allergens, a clear indication of dose responsiveness, the researchers say. "We honestly do...Hawaiian Whales Show 'No Overt Response' To Sounds Of ATOC Simulation
...en deafen -- whales and other marine mammals with sensitive hearing. Run by Scripps Institution of Oceanogra...uals, just like people, and some appear to be more sensitive than others," Frankel said. "Some react to a given vessel and some do not. Likewise, we may exp...Newly Discovered Gene Halts Cell Division and May Have Cancer Link
... identified a human breast tumor cell line that is sensitive to the cancer drugs taxol and nocodazole. The drugs, called spindle inhibitors, block the formation of the thread-like fibers that pull chromosomes apart during cell division. After the researchers treated the breast tumor cell line with nocodazole,...Changing Continental Runoff Patterns Could Change Ocean Circulation
...eans' deep water formation patterns may have been sensitive to variations in continental runoff," Bice told attendees today (Oct. 29) at the annual meeting of the Geological Society of America in Denver. Researchers using the general circulation models have not previously considered continental runoff....North America Hit Hard By Asteroid Strike In Yucatan 65 Million Years Ago
... the base of the food chain, plants are considered sensitive indicators ofenvironmental devastation. Because ferns reproduce through the use of hardyspores, the plants are regarded as key flora in colonizing the site of anatural disaster. Plants in parts of the world not downrange from the impact took a lesse...New Sensor Provides First Instant Test For Toxic E. coli Organism
...ue-tintedpolydiacetylene (PDA) film. PDA films are sensitive to changes on their surfaceas manifested by the wavelength of light they transmit. When E. coli 0157:H7toxins bind to their synthetic membrane surface, the backbone chain of PDAreorganizes. The sensor that was blue turns red. With the abili...Birds Deal With "Cocktail Party Effect"
... To his astonishment,the birds were not especially sensitive to whether the sequenceswent up or down in pitch. Instead, they possess a trait rarelyfound in people, called absolute pitch, which enables them toimmediately identify the pitch of an isolated tone. Theimplication is that the birds may use this talen...High Levels of Vitamin C Prove Toxic to HIV
...ed cells grown in the laboratory appear to be more sensitive to the toxic effects of vitamin C, explained Dr. David W. Golde , Physician-in-Chief of Memorial Hospital and senior author of the paper. At the same levels of exposure, the HIV-infected cells took in more vitamin C than uninfected immune cells. Th...Fund Aims To Repay Developing Nations For Valuable Genes
...cegenes could pave the way to more environmentally sensitive production methodsby eliminating the need for many of the chemical pesticides currently usedin rice farming. While attending a 1996 Rockefeller Foundation meeting on intellectualproperty rights, Ronald struck up a conversation with John Barton, the ...Chemists Compute Answers To The Origin Of Gout
...and reactivity of chemicals - and for dangerous or sensitive species, modelling is completely safe.Other projects currently under way at the new group are: A study of how nitrogen gas binds to natural enzymes and is converted to fertiliser so effortlessly when, for the same process, mankind uses industrial c...Overweight Cats Risk Disease And Premature Death, Cornell Study Finds
...rian's office. Veterinarians have scales that are sensitive enough to pick up slight changes in weight in an 8- to 15-pound animal, changes that are very important when we're trying to see if our attempts to get weight off the kitty are effective. Just like going to Weight Watchers meetings for humans, there...Resistance To Leptin Contributes To Obesity
...ight when give injections of leptin, but were less sensitive thanthe lean mice. Also, the DIO mice fed the regular diet had a greaterresponse to high doses of injected leptin than DIO on high-fat diets:losses of 83 vs. 30.5 percent of body fat. In the ICV infusion studies,NZO mice responded to low doses of 5......Carolina-based Research Triangle Institute, to use sensitive clinical tests to evaluate more ill and well Gulf War veterans for neurological damage and to design a national survey to determine how many Gulf War veterans need treatment. "This is the logical and crucial next phase to meet the goals of our resear...Common Food Dye Can Cause Severe Allergic Reactions
...community be able to determine how many people are sensitive to cochineal extract. "If we don't look for it," he says, "we're not going to find it." He does not advocate removing the colorant from the market, and points out that several large studies have found it to be safe and non-toxic. It would ...Study Shows Hereditary Legacy Of Radiation Exposure
...nce Livermore National Laboratory have useda very sensitive model they developed to demonstrate that if a male...r seven weeksbefore conception, corresponding to a sensitive stage in sperm development.These grandchildren mice also weigh less than normal mice and their sperm...Genetic "Short Circuit" Leads To Cleft Palate
...ound two strains of specially bred mice-one strain sensitive to steroid-induced clefting, the other strain resistant. Using these mice they have now pieced together a molecular explanation for cleft palate. The genetic circuit that they describe is similar to an old-fashioned string of holiday lights that......ted toit." Nerve cells in the epithelium, sensitive tissue lining the nasal cavity,are capable of recognizing and responding to an extraordinarily large repertoireof stimuli -- some 10,000 chemical odors. They accomplish this feat, at least inpart, with numerous mucus-coated fibers, which contain the...Experimental Trial Combines DNA Vaccine With Triple-Drug Therapy To Stop HIV
...atients to levels undetectable by all but the most sensitive assays.Immune system function is often restored in individuals receiving this therapy,returning them to health. They cannot be considered cured, however, because thevirus lingers quiescently in certain subpopulations of T cells. The experime...