New mechanism for display of foreign proteins to immune system
... It is well established that the immune system has sentinel cells whose job it is to report the presence of fo...ancers. In a process called crosspresentation, the sentinel cell internalizes foreign proteins, called antigens, from the environment and breaks them up into ti...Other Highlights in the June 2 JNCI
... and colleagues explored how the revision affected sentinel lymph node positivity, the false-negative rate, and the overall accuracy of the sentinel lymph node biopsy in a cohort of 205 breast cancer patients undergoing breast cancer surgery that in...Other highlights in the May 5 JNCI
... A new method that allows researchers to visualize sentinel lymph node drainage in mice may be able to detect ...agents during magnetic resonance imaging to detect sentinel lymph node drainage in normal mice and mouse models of breast cancer. Using this method, regions of ...Disease-fighters in our mouths provide clues to enhancing the immune system
...teria, such as P. gingivalis. Special receptors on sentinel cells may help them detect invading pathogens. Clark's session will discuss how these sentinels activate both the innate and acquired immune systems. In her session on beta-defensins, Dale will discuss the ways that these natural antibiotics are acti...Natural killer cellers are made, not born
...ls await activation (probably after stimulation by sentinel dendritic cells) before they react in two distinct modes. In one mode, they promptly secrete cytokines, chemical messenger proteins, which modulate emerging T and B immune cell responses. In the other, they become potent killers of tumors and virus-i...Carnegie Mellon enhances Quantum Dot Corp. technology for long-term, live-animal imaging
...ul for defining some tumor types and for detecting sentinel lymph nodes, according to Ballou. (A sentinel lymph node is the first lymph node to which a cancer spreads.) The Carnegie Mellon researchers plan ...Researchers identify new cause of genomic instability
...2AX and p53 -- a gene that produces a molecular sentinel protein that suppresses proliferation of cells with damaged DNA. In previous studies, Alt and his colleagues had shown that loss of p53 in cells that lacked the DNA-repair process known as non-homologous end-joining (NHEJ) resulted in a dramatic incr...Researchers developing 'sentinel plants' to warn of bioterrorism
...s to act as sentinels in various situations." Such sentinel plants have several possible uses. They might be able to sense and warn of the presence of chemical warfare agents or animal pathogens, such as anthrax. Other plants might be designed to detect and signal the presence of explosives in soil, which wou...New study shows tea extract protects skin
...e first to recognize foreign agents. They are the sentinel cells or watchdog cells, essential in detecting germs and mutated proteins produced by cancerous cells; but, because of their location, the Langerhans cells are very sensitive to damage by sunlight. Scientists in the study found the white tea extrac...Honey bee genome being sequenced
...being studied by the U.S. Department of Defense as sentinel species that could detect and locate agents of harm, such as chemical or biological threats. "It would appear their olfactory capabilities are at least on par with a dog, if not more sensitive," Weaver added. According to Johnston, the honey ...Promising biomarker for melanoma is identified
...gnosis, sometimes combined with a procedure called sentinel node biopsy, is used to assess whether a patient's tumor will recur and if additional treatment with immunotherapy is warranted after the cancer is removed. Patients with early stage melanoma, called stage I cancer, have the thinnest lesions and are ...Story tips from the Department of Energy's Oak Ridge National Laboratory, September 2002
... the nation's water supplies . . . ORNL's water sentinel enlists the help of naturally occurring algae biosensors to serve as a first-alert warning system for chemical warfare attacks on water supplies. The system, developed by scientists in the lab's Chemical Sciences Division, works by detecting toxic ch...Deformed frogs form when parasites and pesticides combine
...fect humans," Kiesecker comments. "Frogs may be a sentinel species that is warning us about the interplay between human-caused environmental change and disease susceptibility. Hopefully, people will listen."...Operation of self-aiming camera modeled on how part of brain works
...era system, which could find use as an intelligent sentinel in sensitive military applications, originally was built to demonstrate the versatility of a simulated neural network, which the researchers modeled after the superior colliculus of the human brain. The superior colliculus serves as the visual reflex...USGS issues alert for deadly disease in birds
...ting research on AVM using mallards and coots in a sentinel study for the disease at North Carolina. So far the study has confirmed that the disease is site-specific, i.e. the lakes where birds are dying is the site of exposure. Samples of water, vegetation, and sediments were immediately collected at the l...Plant and animal bacteria share cell-killing mechanism
...efficiently by first slipping inside immune system sentinel cells and cutting off the communication lines they need to call for help. Now scientists at the University of Michigan have discovered the molecular mechanism Yersinia uses to sever these vital cell signaling pathways. It turns out to be an ancien...Sandia, University Of Montana Researchers Try Training Bees To Find Buried Landmines
...led Biological Systems Program supportsresearch of sentinel species (such as bees, wasps,caterpillars, and moths), biohybrids (robotic systems thatmake use of animal features), and robotic systems fordetection of contaminants and other environmental variables. "The beauty of this approach is that bees are ind......lthough the tree swallow is proving effective as a sentinel for sediment PCBs that can enter the food chain, PCB concentrations found at the study sites so far have not been high enough to cause obvious harm. ("The Tree Swallow (Tachycineata bicolor) as a Sentinel Species for Sediment Contaminant Presence, Bi...... on aquatic insects, can serve as anon-fish-eating sentinel species for contaminant exposure from the aquaticenvironment. ("Biomarker Response of Tree Swallows to PCBs," by Mark J. Melanconand Amy L Yorks Kutay, USGS, Laurel, Md.) Nesting Success of Snowy Plovers on Artificial Wetlands Uncertain -- Sat., Se......ation. "We look at the Seychelles people as a sentinel population,"says pediatric neurologist Gary Myers, who examined the children."If somebody who eats fish twice a day does not show effects frommercury exposure, it's unlikely that somebody who eats fish twicea week will be affected. And the fish they ...